Global ETD Search
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Showing 1 to 5 of 5 for “"UPC2"”.
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Signal Transduction and Transcriptional Regulation Pathways Essential for Azole Resistance in Candida albicans
… In C. albicans, the transcription factor Upc2 is central to the regulation of ergosterol biosynthesis. UPC2 activating mutations contribute to azole resistance, whereas disruption increases azole susceptibility. We further investigated the relationship of UPC2 to fluconazole …
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… albicans, the zinc cluster transcription factor Upc2p has been shown to regulate the expression of ERG11 and other ergosterol biosynthesis genes. Overexpression of UPC2 increases azole resistance while disruption of UPC2 results in hypersusceptibility. Using genome-wide gene expression profiling, …
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ERG11-Mediated Azole Resistance in Candida albicans
… the zinc-cluster transcription factor <em>Upc2</em> has been shown to regulate the expression of <em>ERG11</em> and other genes involved in ergosterol biosynthesis.</p> <p>In a large group of clinical <em>C. albicans</em> isolates enriched for azole resistance, I created a transcriptional …
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Delineating the Upc2A Regulon in Candida glabrata
… fungal infection. The transcription factor Upc2 regulates the expression of sterol biosynthesis genes in yeast. Disrupting UPC2A in C. glabrata greatly increases its susceptibility to fluconazole (FLU) in both FLU-susceptible and -resistant clinical isolates. Therefore, the Upc2A and its …
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Novel Determinants That Influence Azole Susceptibility in Candida glabrata and Candida albicans
… to overcome this clinical problem. </p> <p>Upc2 and Ecm22 in <em>S. cerevisiae </em>and Upc2 in <em>C. albicans </em>are the transcriptional regulators of <em>ERG11</em>, the gene encoding the target of azoles in the ergosterol biosynthesis pathway. Recently two homologs for these …