Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"UNC-49"”.
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Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
… drug target must be found and characterized. Hco-UNC-49 is unique parasitic nematode γ-aminobutyric acid (GABA) gated chloride channel that may prove to be a novel drug target. The objective of this thesis was to characterize intramolecular interactions of Hco-UNC-49B. Two sets of oppositely …
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The Pharmacological Characterization of Hco-UNC-49, a GABA-gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
… nematode that infects ruminants worldwide. Hco-UNC-49 is a H. contortus GABA-gated chloride channel and is an orthologue to the UNC-49 channel from the free-living nematode Caenorhabditis elegans. Previous research by our group has shown that while the UNC-49 channels from the two nematodes …
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An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
… importance such as cattle, sheep, and goats. UNC-49 is a GABA-gated chloride channel found to be exclusive to nematodes which could be a viable future target for anthelminthic drugs. An analysis of the model of the Hco-UNC-49 receptor has identified potentially interacting residues that may be …
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A molecular characterization of agonists that bind to Hco-UNC-49, a GABA-gated chloride channel from Haemonchus contortus
… required for sustainable parasite control. UNC-49 is a nematode ligand-gated ion channel that plays an important role in muscle contraction required for normal locomotion. However, little is known regarding its sensitivity to different agonists and how they interact with the binding site. …
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Molecular characterization of the binding site of nematode GABA-A receptors
… receptors of the parasitic nervous system. Hco-UNC-49 is a nematode GABA receptor that has a relatively low overall sequence homology to mammalian GABA receptors but is very similar to the UNC-49 receptor found in the free living nematode Caenorhabditis elegans. However, the nematode receptors …
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Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
… and as such are promising drug targets. The UNC-49 (GABA-gated chloride channel) and ACC (acetylcholine-gated chloride channel) family of receptors have been characterized as potential drug targets in other nematodes. However, these receptors have yet to be identified or characterized in D. …
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Molecular characterization of GABA receptor subunits from the parasitic nematode Haemonchus contortus
… two H. contortus ion channel genes, Hcounc- 49B and C that encode two GABA-gated chloride channel subunits. Electrophysiological analysis shows that the Hco-UNC-49B subunit forms a functional homomeric channel in Xenopus laevis oocytes that produces a robust response to GABA and is …
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Investigation of two Interacting Neurosteroid Sites on a GABA Receptor by Mutagenesis and Mathematical Modeling
… resistance. The C. elegans GABA receptor, UNC-49, is modulated by the neurosteroids pregnenolone sulfate and pregnanolone, identifying neurosteroids as potential lead compounds. Notably, neurosteroid sites are non-conserved between invertebrates and mammals, limiting possible …
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Investigation into potential Dirofilaria immitis drug targets through rational anthelmintic synthesis and design
… chloride channel unique to nematodes and the UNC-49 GABA receptor. In total, 22 compounds, 12 of which are novel, were synthesized, including imidazole-4-acetic acid like compounds, levamisole derivatives, and a levamisole dimer. Compounds 8-15 were tested on the Hco-ACC-2 receptor using …
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Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
… characterize the agonist binding pocket in Hco-UNC-49BC, the LGCC gated by γ- aminobutyric acid (GABA) within H. contortus. To meet this objective, each amino acid residue in binding loop E was changed to a cysteine and analyzed via electrophysiology and the substituted cysteine accessibility …