Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"UMAP"”.
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Autoencoding variational inference for the visualization of velocity-enriched scRNA-seq data
… for dimensionality reduction, such as t-SNE and UMAP, are agnostic to the concept of velocity and therefore will embed data agnostic to any such additional information. In this work, we leverage variational inference to design deep learning models that use expression data and velocity data in …
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Branching out: how a planarian neoblast generates cellular diversity
… manner. We find that cells close together in UMAP space, but belonging to different cell clusters through traditional clustering, are often difficult for the neural networks to distinguish. From this, we hypothesize that cells in different clusters may be transcriptionally similar and cells …
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Reconstructing Past Population Dynamics and Movements from Genomic and Environmental Data
… a popular non-linear dimension reduction tool, UMAP, in the context of high-dimensional biological data. UMAP has been widely used for inferring population structure and cell clusters since its development, but its mathematical principle is non-trivial for most biological scientists, and often …
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CancerSubtyper: A Web-Based Deep Learning Platform for Cancer Subtyping Through DNA Methylation Data
… through various interactive plots including UMAP projections, boxplots, and Kaplan–Meier survival curves. We evaluate the platform using The Cancer Genome Atlas (TCGA) breast cancer cohort, demonstrating distinct cancer subtypes, effective batch correction, and clinical relevance via survival …
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Geometric Dimensionality Reduction
… methods of dimensionality reduction such as UMAP (Uniform Manifold Approximation & Projection) and t-SNE (t-distributed Stochastic Neighbor Embedding) suffer from irreversibility, hyperparameter tuning sensitivity, and computationally costly internal processes. Even LLE (Local Linear …
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Investigating the coordination of germline stem cell fate by ecdysone signaling and BMP signaling in the Drosophila ovary
… differences between the three tumor genotypes. UMAP distribution and differential gene expression show that the over-expression of EcR.B1 and constitutively active tkv (TkvACT) yield undifferentiated cells that are more similar to each other than they are to the bam-depleted cells. Knock-down of …
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Design of empirically-grounded mutation operators for terraform IaC
… A fase quantitativa utilizou Sentence-RoBERTa, UMAP e HDBSCAN para agrupar mensagens de commit e identificar padrões de defeitos recorrentes. Estes resultados foram triangulados com os insights obtidos dos especialistas, resultando em uma taxonomia unificada da qual um catálogo de operadores de …
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Pareto Task Inference Analysis of Single-Cell RNASequencing of Human Placenta Reveals Biological Insightsinto Adverse Pregnancy Outcomes
… dimensionality-reducing methods such as UMAP-based clustering. However, these techniques may generate limited representations of nuanced cellular functions and biological relationships among and within cell clusters. Pareto Task Inference (ParTI), a dimensionality reduction technique that …
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An Ai-Powered 3-D Facial Recognition Framework for Crime Intelligence using Reconstructive and Predictive Techniques
… k-NN classification, perclass diagnostics and UMAP visualisation. Crime-trend analytics built from anonymised UK open police data in Facebook/Meta Prophet, with the use of a full-stack investigator dashboard feeding from REST endpoints. Governance components simulate the automated DPIA, …
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Orthogonal Comparison of Nuclear and Mitochondrial Clonal Architectures in Hematologic Malignancies
… using R and Python for quality filtering, UMAP visualization, and clonality inference. Mitochondrial variants were annotated to determine functional impact.</p> <p>In parallel, scWGS data from previously profiled multiple myeloma patient samples were analyzed using Mutect2 to reconstruct …
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Theological Higher Education in Cuba: A Case Study of the Eastern Cuba Baptist Theological Seminary
… to work at the Military Units to Aid Production (UMAP). Fidel Castro recognized in 1991 that the Cuban Communist Party erroneously made atheism its religion. Although the Cuban communist regime never issued an antireligious policy, in subtle ways Christians suffered the consequences of the …
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Rapid and high-resolution analysis of winemaking yeasts using MALDI-TOF MS : A thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… reduction techniques (DRTs) of PCA, MDS and UMAP were performed to analyse the data by using BioNumerics v 7.6 and the conda-forge packages for Python. Compared to the routine DM method, PM improved the performance of MALDI-TOF MS on wine-associated yeast analysis and yielded well-defined …
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Computational techniques to interpret the neural code underlying complex cognitive processes
… identified that non linear algorithms such as UMAP are more adaptable across datasets of varying noise and behavioural complexity. Furthermore, the review visualises how NML can be applied to disease states in the brain and introduces the secondary analyses that can be used to enhance or …
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Visualising Energy Landscapes Through Manifold Learning
… reduction for visualisation, such as t-SNE and UMAP, is described. Following this outline, we provide motivation for adapting these existing approaches in order to deal with structural data, before presenting our new method designed for application to PESs: SHEAP. SHEAP is compared to the …
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Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… similar but spatially separate on the UMAP plot. CD52-low naïve B cells downregulated IGHM, indicative of an anergic phenotype. CD52-low germinal centre B cells displayed elevated Bach2 and Il21r expression, suggesting they may hold a competitive advantage within a germinal centre …