Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"UK Biobank"”.
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A contemporary history of the origins and development of UK Biobank, 1998-2005
… examines the origins and early development of UK Biobank. This is a resource funded in 2002 by the Medical Research Council, the Wellcome Trust, the Department of Health and the Scottish Executive to gather genetic and lifestyle information from half a million participants aged 4069 years old …
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A Genome-Wide Association Study on Widespread Pain using the UK Biobank Cohort
… associated with widespread pain in a cohort of UK Biobank participants who had completed a pain phenotyping questionnaire.<br/><br/><b>Method</b>: Cases and controls were determined by a question answered by UK Biobank participants. The question contained 10 selections to identify different pain …
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Genetic Determinants of Human Susceptibility to Infections: A Multi-faceted Exome-based Analysis in the UK Biobank
… through three interconnected studies utilising UK Biobank datasets. These studies investigate the relationships between genetics, exomes, and immune responses, focusing on serological antibody responses to common pathogens, broader phenotypic effects of infection-related genetic variants, and …
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Clinical Drug-Gene and Drug-Drug-Gene Interactions for the Most Commonly Used Chronic Drugs in the UK
… commonly used chronic drug combinations in the UK.<b><br/></b><b><br/></b><b>Methods</b>: Using the UK Biobank (cross-sectional) cohort and 3 other Scottish cohorts (longitudinal), I have studied the association of 162 genetic variants in important genes with three drug response phenotypes for …
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Investigating Inflammatory Pathways in Alcohol-Associated Liver Disease
… of drinking, liver iron and liver fat in a UK BioBank cohort. Results show 350 mM ethanol led to a 50% decrease (p<0.0001) in cell viability at 72 hrs and a significant increase in ROS at 30 mins (p=0.0027). At 72 hrs a substantial number of cells were late apoptosis (44%) (p=0.0153) as well …
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Detection, causes and consequences of sex chromosome mosaicism
… chapter 2, in genetic data derived from 205,604 UK Biobank males and 243,765 females, the new method improved the accuracy of LOY/LOX estimation as measured by the strength of association between LOY/LOX and age, smoking status, and polygenic risk of LOY/LOX derived from previous GWAS. In chapter …
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Epidemiological investigations of liver cancer: biomarkers, reproductive factors and modifiable risk factors:
… Unit (PCCIU) and a cohort study using UK Biobank. We found an increased risk of liver cancer, especially of intrahepatic bile duct carcinoma in proton pump inhibitors users but not in histamine-2 receptor antagonists users. This novel association requires further research to determine …
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Unravelling the Genetics of Cerebral Small Vessel Disease
… arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by NOTCH3 variants, and the second most frequent, CADASIL type 2, by autosomal dominant HTRA1 variants. COL4A1/2 variants can cause small vessel stroke and intracerebral haemorrhage. This thesis investigates the …
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Inclusive and adaptive assessment of cardiorespiratory fitness for population health research
… inclusive, adaptive, and robust research. In the UK Biobank study, I develop and validate a novel approach to estimate fitness in approximately 80,000 adults who performed a risk-stratified cycle ergometer test. I then apply this method to examine associations with mortality, cardiovascular …
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The genetics of cognition in Schizophrenia
… living with schizophrenia. Second, data from the UK Biobank was used to investigate the common genetic determinants of WIV. Third, genetically informed factors corresponding to broad cognitive abilities were used to explore the overlap between the latent cognitive factors, schizophrenia, and …
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The genetics of cognition in Schizophrenia
… living with schizophrenia. Second, data from the UK Biobank was used to investigate the common genetic determinants of WIV. Third, genetically informed factors corresponding to broad cognitive abilities were used to explore the overlap between the latent cognitive factors, schizophrenia, and …
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Phenotyping Ethnic Differences in Body Fat Depots
… I include data from three adult cohorts: the UK Biobank (n=9533) of mixed ethnicities, the DIRECT cohort (n=1553) of Cau pre-diabetic individuals and The West London Observation (TWLO) cohort (n=747) of mixed ethnicities. In addition, I present data from Pune Maternal Nutrition study (PMNS) …
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Exploring Multivariate Gene-Environment Interactions: Models And Applications
… This, together with the collation of large-scale biobanks that contain a multitude of phenotypic and environmental data (facilitating an increase in the number of G$\times$E effects detected) has generated the need for methods that jointly account for G$\times$E at multiple environments. Such …
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Investigation of brain ageing in HIV-positive individuals using convolutional neural networks
… in HIV-positive individuals. We utilise the UK Biobank, CamCAN, and ENIGMA-HIV datasets for this task and train a convolutional neural network in two stages. First, we pre-train the model on the large UK Biobank dataset (N=21366) which contains individuals in the age range of 45-82 years. To …
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Butyrophilin family genes as putative coeliac disease risk loci
… 2). The prevalence of CeD in the United Kingdom (UK) is around 1% and the number of new CeD diagnoses is rising each year (3, 4). Active CeD, when individuals predisposed to CeD consume dietary gluten, is characterised by an increase in intraepithelial lymphocytes (IELs), and mucosal damage, …
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Association of cardiovascular and musculoskeletal biomarkers with clinical outcomes in chronic obstructive pulmonary disease.
… and the associated length of stay. Data from the UK Biobank were used to explore cause-specific deaths in COPD. Sex-specific all-cause and cause-specific mortality rates were age-standardised using the 2013 European Standard Population. Hazard ratios were estimated using Cox proportional hazards …
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Association of blood lipids, atherosclerosis and statin use with dementia after stroke
… the limitations in the CPRD data, I further used UK Biobank to explore whether the CPRD results could be replicated using similar analytic strategies. Results: My systematic review suggested that hyperlipidaemia was not associated with post-stroke dementia, atherosclerosis was associated with …
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Risk of depression and cardiovascular disease across the lifespan: the role of systemic inflammation.
… and Children (ALSPAC) and the United Kingdom (UK) Biobank to study associations between inflammation, depression, and CVD risk in different age groups. ALSPAC is a prospective birth cohort of 15,000 individuals born in and around Bristol in 1990/91. In contrast, UK Biobank is a long-term …
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Medications, sex hormones and reproductive factors in relation to gastro-oesophageal cancer risk and survival
… has not been studied. A cohort study using UK primary care records from the Clinical Practice Research Datalink (CPRD) database was conducted to examine this association and found furosemide did not improve gastro-oesophageal cancer survival. Also within the CPRD database, use of medications …
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Painting the Past: Uncovering Ancestral Contributions to Complex Human Phenotypes in Western Eurasia
… local ancestry in a large modern panel, the UK Biobank, using new ancient reference genomes. Modern samples were selected based on a ‘typical ancestral profile’ for each country represented in the UK Biobank. This dataset was then used to infer the genome-wide ancestry components of modern …
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