Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"UHRF1"”.
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UHRF1 and the DNA Damage Response
… as Nuclear protein 95 (Np95) which now is called UHRF1 (Ubiquitin-like, containing PHD and RING finger domains, 1). Although previous studies demonstrate the importance of Mus81-Eme1 enzyme in DNA repair, genome integrity, and tumor suppression, little is known about how the enzyme acts together …
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The Regulation of UHRF1 during Mammalian Embryogenesis
… demethylation are orchestrated by regulation of UHRF1, which recruits the maintenance methyltransferase DNMT1 to newly replicated DNA. This project set out to elucidate the mechanism(s) by which UHRF1 protein is regulated during epigenetic reprogramming. Further dissection of the regulation of …
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Disruption of UHRF1 expression in chicken DT40 cells
… of cancer. Among the epigenetic regulators, UHRF1 (ubiquitin-like with PHD and ring finger domain containing protein 1) has attracted considerable attentions in cancer research in past years due to its universally increased expression in a wide range of different cancer cells, and its ability …
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THE ROLE OF DNA REPAIR IN DNA METHYLATION DYNAMICS
… in developmental potency. In addition to Uhrf1 and the Tet enzymes, the interplay between activation induced cytidine deaminase (AID) and the DNA repair machinery has been implicated in epigenetic reprogramming of various in vivo and in vitro systems including mouse primordial germ cells, …
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Molecular mechanisms of acquired gemcitabine resistance in pancreatic cancer
… cells is reversibly regulated by DNMT1 and UHRF1. Furthermore, I found that 14-3-3σ over-expression causes gemcitabine resistance by inhibiting gemcitabine-induced apoptosis and caspase-8 activation possibly via binding to YAP1. The finding of demethylation of the 14-3-3σ gene in gemcitabine …
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The Regulation of Dna Methylation In Mammalian Development and Cancer
… by impairing the recruitment of the Dnmt1-Uhrf1 complex to chromatin, thereby identifying a novel crosstalk between histone arginine methylation and DNA methylation. Moreover, I show that PRMT6 upregulation contributes to global DNA hypomethylation in cancer. Lastly, my work results in the …
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Towards elucidating the function of the oocyte Subcortical Maternal Complex: A multi-omic analysis of an Nlrp5-null murine model
… oocytes include epigenetic modifiers DNMT3L and UHRF1, both of which are reduced in the mutant, the former by over 75%, and the latter by 40%. Immunofluorescence analysis of *Nlrp5*-null oocytes indicates an altered DNMT3L localisation, but no change in DNMT1 localisation. Single-cell …
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TARGETING THE DNA DAMAGE RESPONSE PATHWAY FOR THE TREATMENT OF AGGRESSIVE THYROID CANCERS, IN VITRO STUDIES
… The p53 and Chk1 functionally related gene UHRF1, regulating under p53 control cell cycle progression and VEGF expression, resulted to be overexpressed in samples derived from TKI resistant patients, thus providing mechanistic and prognostic insights in TC patients response to TKIs. …
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HDAC inhibition results in suppression of FOXM1 and genes associated with poor prognosis prostate cancer through p53 dependent and independent mechanisms
… impacts expression of genes such as MYBL2, UHRF1, RRM2 and BRCA1 that are central in cell cycle and DNA repair, through suppression of FOXM1, a nodal regulator of these processes.<br/><br/>These results uncover a multi-modal mechanism of action for Entinostat, whereby induction of p21, …
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DIFFERENTIAL GENE EXPRESSION DURING ISCHEMIA AND REPERFUSION IN AN EXTRACORPOREAL SMALL BOWEL PERFUSION MODEL IN SWINE
… Transkriptionsfaktor in Frage, während SNAP23, UHRF1, DDEF1, FAT, RPL3 und STK12 an Differenzierungs- und Proliferationsprozessen beteiligt zu sein scheinen. Bei unseren Versuchen entdeckten wir außerdem vier, beim Schwein bisher nicht bekannte, Gene, die wir in der GenBank registrieren ließen: …
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Regulation of De Novo and Maintenance Dna Methylation By Dnmt3A and Dnmt3B
… <em>de novo</em> methylation by DNMT3A/3B, and UHRF1, a 5mC reader, targets DNMT1 to hemi-methylated CpG sites during DNA replication to facilitate maintenance methylation.</p> <p>The finding that 5mC can be converted to 5-hydroxymethylcytosine (5hmC) and other oxidized derivatives by the …