Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"UHPLC-MS"”.
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Studies of UHPLC-MS performance and application to rapid sensitive and robust drug analysis
… of ultra high performance liquid chromatography (UHPLC) performance with a particular focus on the application of liquid chromatography-mass spectrometry (LC-MS) for the analysis of basic drugs. UHPLC-MS technologies are investigated to facilitate fast, sensitive and robust analysis of drugs in …
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Development of multi-mycotoxin UHPLC-MS/MS methods and application to oat and beer samples
An analytical UHPLC-MS/MS method was developed and validated for the identification and quantitation of 42 mycotoxins in unprocessed oat grains intended for human consumption. The method included all the mycotoxins listed under the current European legislation as well as a wide range of analytes of …
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An Evaluation Of UHPLC-MS Technology Encompassing Elevated Temperatures, Low Viscosity Operation and Recently Developed Stationary Phase Materials
… To begin with, a standard application of UHPLC-MS was developed for the high throughput quantification of quinine and its major metabolite. In attempting to expand the performance capabilities of ultra-pressure systems a high temperature column oven was evaluated. It was found to be mostly …
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Optimising the Wider Energy Metabolome of Microbes Using Targeted UHPLC-MS/MS Present in Bio-Electrochemical Systems for Carbon Dioxide Conversion to Platform Chemicals
… by developing and validating a rapid, sensitive UHPLC-MS/MS platform for simultaneous quantification of the key intracellular energy metabolites that govern redox balance, energy charge, and carbon flux in industrial microorganisms. The method was designed to improve and optimise quenching, …
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Effect of a novel contraceptive compound on vaginal health
… the counter contraceptive options, such as condoms and spermicides, but these methods have failure rates between 13-21 percent. Additionally, spermicides can cause damage to the vaginal epithelium and can increase susceptibility to sexually transmitted diseases (STDs). As such, our laboratory has …
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Pasture feeding impacts on lamb lipid composition and on blood plasma and cardiovascular risk factors in humans
… and characterised lipid species using untargeted UHPLC-MS/MS analysis. Nine lipid species were identified as significantly different between grass vs concentrate diets. Lipid species phosphatidylethanolamine (18:1e_18:1) and lyso-phosphatidylcholine (18:2) were identified as possible biomarkers …
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Assessment of road pollutants in roadside retention ponds.
… concern. Sustainable urban drainage systems (SuDS) such as retention ponds manage runoff and are a key pathway for pollutants from roads to the wider aquatic environment. Hence the aim of this work was to assess retention ponds as a pathway for TRWPs, MPs, and additive chemicals entering …
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Συμβολή στη φαρμακογνωστική αξιολόγηση του Sideritis clandestina
… η χημική σύσταση του αιθέριου ελαίου με GC-MS με τη μέθοδο της υδροαπόσταξης. Η απόδοση σε αιθέριο έλαιο ήταν πολύ χαμηλή και τα σεσκιτερπένια αποτελούσαν την κυρίαρχη ομάδα. Η υδροαπόσταξη (HD) συγκρίθηκε με την εκχύλιση με υπερήχους (UAE) και τη διαβροχή (MAC) με πετρελαϊκό αιθέρα. Η UAE …
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Performance of septic tanks for pharmaceutical removal and their impact to river water quality.
… coupled to tandem mass spectrometry (UHPLC-MS/MS) in ST influent and effluent, total suspended solids (TSS), sludge and river water was developed. Five community STs and the receiving rivers were studied over 12 months. Concentrations were similar in influent and effluent, exceeded …
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Chemophenetics of selected European plant taxa
Diese Dissertation untersucht die chemische Diversität ausgewählter europäischer Pflanzen aus einer chemophänetischen Perspektive. In vier komplementären Studien werden Metabolitprofile mit taxonomischen Beziehungen, saisonalen Veränderungen und post-harvest Prozessen verknüpft. Vergleichende …
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Improving CNS Delivery of Genistein for the Treatment of Sanfilippo Syndrome
… MPS III. Towards our goals, two major specific aims were proposed: (1) To improve accumulation of genistein in brain and (2) To evaluate the efficacy of genistein formulation. Methods: Genistein nanosuspensions were prepared by wet milling technique and characterized in order to select the most …
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Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods for screening of selective androgen receptor modulators in urine and blood
… selective androgen receptor modulators (SARMs). SARMs were discovered in the late 1990s as promising alternatives to AAS due to their ability to separate anabolic effects on target tissues from unwanted androgenic effects. Nowadays, the potential therapeutic applications of SARM compounds …
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Emerging anabolic drugs - investigation of the in vitro and in vivo metabolism of selective androgen receptor modulators
Selective androgen receptor modulators (SARMs) are a novel class of orally active, tissue-selective small molecule androgen receptor ligands with potential use for human therapeutic purposes. While SARMs show similar myoanabolic effects to anabolic androgenic steroids with reduced side effects, …
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APPLICATION OF OMICS APPROACHES IN DRUG DISCOVERY AND BIOMARKER IDENTIFICATION
… tools are required. Mass spectrometry (MS) coupled with liquid chromatography (LC) is one of the most powerful analytical platforms for the analysis of the lipidome in complex biological matrices and offers promising new insights in this field. Lipids are a large class of biomolecules …