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Showing 1 to 20 of 49 for “"UHPLC"”.
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Studies of UHPLC-MS performance and application to rapid sensitive and robust drug analysis
… of ultra high performance liquid chromatography (UHPLC) performance with a particular focus on the application of liquid chromatography-mass spectrometry (LC-MS) for the analysis of basic drugs. UHPLC-MS technologies are investigated to facilitate fast, sensitive and robust analysis of drugs in …
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Development of multi-mycotoxin UHPLC-MS/MS methods and application to oat and beer samples
An analytical UHPLC-MS/MS method was developed and validated for the identification and quantitation of 42 mycotoxins in unprocessed oat grains intended for human consumption. The method included all the mycotoxins listed under the current European legislation as well as a wide range of analytes of …
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Deciphering the chemistry of host-parasitic plants interactions using the UHPLC-q-TOF-MS and chemometrics
… compared to that of V. combreticola using the UHPLC-q-TOF-MS and classical molecular networking. These two species were found to be chemotaxonomically distinct, with V. album mainly consisting of flavonoids conjugated to 3-hydroxy-3-methylglutaric acid. Lastly, chemically diverse polyphenols …
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An Evaluation Of UHPLC-MS Technology Encompassing Elevated Temperatures, Low Viscosity Operation and Recently Developed Stationary Phase Materials
… To begin with, a standard application of UHPLC-MS was developed for the high throughput quantification of quinine and its major metabolite. In attempting to expand the performance capabilities of ultra-pressure systems a high temperature column oven was evaluated. It was found to be mostly …
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Optimising the Wider Energy Metabolome of Microbes Using Targeted UHPLC-MS/MS Present in Bio-Electrochemical Systems for Carbon Dioxide Conversion to Platform Chemicals
… by developing and validating a rapid, sensitive UHPLC-MS/MS platform for simultaneous quantification of the key intracellular energy metabolites that govern redox balance, energy charge, and carbon flux in industrial microorganisms. The method was designed to improve and optimise quenching, …
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Analytical methods for the determination of endocrine disruptors, UV filters and plastic additives in packaging and pharmaceuticals
… UV filters by HPLC-DAD, plastic additives by UHPLC-(ToF)MS and perfluorinated compounds by UHPLC-(QToF)MS/MS. In each work, a focused ultrasonic solid-liquid extraction (FUSLE), a fast, simple and relatively new extraction technique, is developed and optimized; and its efficiency is evaluated …
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Emerging anabolic drugs - investigation of the in vitro and in vivo metabolism of selective androgen receptor modulators
… quadrupole time of flight mass spectrometry (UHPLC-QTOF MS) analysis. All fractions produced metabolites that have previously been described as important target analytes of the investigated SARM compounds, demonstrating that the proposed simple and low-cost liver homogenate approach holds …
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Analysis of antibiotics and PFAS as potential emerging pollutants in the water bodies and their accumulation in food samples
… antibiotics in macadamia nuts prior to UHPLC-qToF-MS analysis. In paper IV, a novel deep eutectic solvent was synthesised and characterised using FTIR spectroscopy. For the first time the synthesised deep eutectic solvent was applied for extraction of multiclass antibiotics in green …
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Adsorption of Organic Pollutants onto Microplastics
… ultra-high performance liquid chromatography (UHPLC). The UHPLC parameters and figures of merit for EtP and BP-3 were established. The adsorption experiments used size of MPs, weathering of MPs, and time as the experimental variables. Pristine small and large MPs were used to show how the …
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Safety Assessment and Chemical Fingerprint Analysis of Medicinal Plants Commonly Consumed As Herbal Teas; Rooibos (<em>Aspalathus Linearis</em>) and Moringa (<em>Moringa Oleifera</em>)
… from rooibos tea and dietary supplements using UHPLC-PDA-MS was developed to determine14 chemical constituents. The compounds were detected in the range from 1.50-9.85 %in twenty-one dietary supplements with higher content observed for the unfermented products. The characterization and …
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Συγκριτική μεταβολομική μελέτη δειγμάτων Origanum majorana L. από διαφορετικές καλλιεργητικές διαχειρίσεις
… Τα δείγματα αναλύθηκαν με τη χρήση συστήματος UHPLC-VIP-HESI-TIMS-QTOF-MS μέσω στοχευμένης σάρωσης. Συνολικά, προσδιορίστηκαν 15 ενώσεις, οι οποίες ανήκουν στις κατηγορίες των φλαβονοειδών και των φαινολικών οξέων/ παραγώγων. Παρατηρήθηκε ότι οι διαχειρίσεις με Fe στο σύνολο των λιπάνσεων, …
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Effect of a novel contraceptive compound on vaginal health
… by liver microsomes and is detectable by UHPLC- MS in its original form. To determine if B1 can traverse the vaginal epithelium and enter circulation, we preformed tissue permeation experiments using Mattek's 3D human EpiVaginal tissue. B1 was not able to traverse human vaginal …
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Study of degradation of aflatoxins after sonication and their determination by HPLC-QqQ-MS
… Τριπλού Τετραπόλου με Ιοντισμό Ηλεκτροψεκασμού (UHPLC-ESI-QqQ-MS/MS). Η μέγιστη αποδόμηση για χρόνο επεξεργασίας 20 λεπτών ανήλθε στο 35% για το πρότυπο διάλυμα της AFB1 και 58.3% στο ρόφημα φυτικής προέλευσης. Παρουσία ανιόντων υπερθειϊκών αλάτων το ποσοστό αποδόμησης της AFB1 έφθασε στο 72%. …
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Pink discolouration in cheese
… including pilot-scale cheese manufacture, UHPLC-DAD-QTof mass spectrometry, shotgun metagenomic sequencing, and exploiting the antimicrobial activity of biopreservative nisin were used to determine the role of Thermus in causing pink defect and to investigate potential control measures. The …
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Assessment of nutraceutical attributes of selected wild edible fruit plants used by Vhavenda people of the Thulamela Local Municipality
… were mentioned for this use. In this study the UHPLC-qTOF-MS/MS-based in source collision induced dissociation method was utilized to generate fragmentation data to assist in the differentiation of closely related isomers. Wild edible fruit plants have been used for centuries in traditional …
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Comprehensive evaluation of cow dung digestate composition for potential soil fertilization: Advanced analytical techniques
… techniques, including FT-IR, ICP-OES, GC-MS, and UHPLC-QTOF-MS, characterized functional groups, elemental composition, volatile organic compounds, and metabolomic profiles. Multivariate data analysis provided a comprehensive assessment of nutrient interactions and biochemical complexity. Results …
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LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS TO HMGB1 AND ITS REGULATED SECRETION IN LUNG CANCER
… mass spectrometry (2D-nano-UHPLC-PRM/HRMS) platform. Secreted HMGB1 was immunoprecipitated with a stable isotope-labeled HMGB1 internal standard followed by CD3-acetylation and protease digestion in order to quantify site-specific acetylation on secreted HMGB1. A similar …
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Inhibitory effects of Green synthesized Senna alexandrina silver nanoparticles (SAAgNPs) on Escherichia coli DnaK
… the phytochemicals of S. alexandrina . FTIR, UHPLC-qTOF-MS, investigated the functional groups present in plant extract to identify the compounds responsible for reducing silver ions. Altogether, findings from this study suggest that DnaK is highly involved in E. coli cytoprotection against …
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Investigation of Novel Microseparation Techniques
Ultrahigh pressure liquid chromatography (UHPLC) makes it possible to use very small particles (< 2 µm) as packing materials to provide high column efficiencies. Results from a careful comparison of small porous and nonporous particles show that when the particle size is small enough (< 2 µm), both …
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