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Showing 1 to 12 of 12 for “"UGT1A1"”.

  1. UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients

    Onoue, MasahideKyoto University2009

    kyoto Repository record

  2. Human liver stem cells transplant extends survival in immunocompromised Crigler Najjar syndrome type I mice by restoring UGT1A1 expression

    Altruda, Fiorella, Famulari, ElviraUniversità degli Studi di Torino2018

    unito Repository record

  3. Korrelation des Polymorphismus der Uridindiphosphat-Glukuronyltransferase Isoform 1A1 mit der Glukuronidierung von Bilirubin und Paracetamol und der klinischen Diagnose des Gilbert Syndroms

    Rauchschwalbe, SonjaUniversität Würzburg

    … nicht nachgewiesen werden. Deshalb scheint die UGT1A1 nicht das für Para-cet-amol verantwortliche Isoenzym zu sein. Die Bestimmung des Genotyps des UGT1A1 Promotors kann zur Vorhersage zukünf-tiger oder Erklärung vorliegender erhöhter Bilirubinspiegel herangezogen werden. Dies kann in der Klinik …

    wurz-thes Repository record

  4. Studies investigating the impact of select genotypes on the pharmacological effect of fenofibrate

    Arafah, Azher2012

    … also confirmed that another genetic variation, UGT1A1*28, had an effect on serum concentration of fenofibric. In contrast to UGT2B7 A-327G, UGT1A1*28 did not cause a lipid response variation. However, UGT1A1*28 did modulated the effect of fenofibrate on bilirubin level. Recognizing and …

    umn Repository record

  5. Relationship Between Flavonoid Structure And Phase-II Metabolism

    Singh, RashimUniversity of Houston2010

    … that flavonoids were mainly glucuronidated by UGT1A1, 1A8 and 1A9 at the substrate concentration of 2.5, 10 and 35μM. 2) To establish the substrate-selectivity and regiospecificity of these major UGT isoform, we found that UGT1A1 showed no regiospecificity for glucuronidating any position, …

    houston Repository record

  6. Tailored chemotherapy based on genomic polymorphisms for metastatic colorectal cancer treated with 5-fluorouracil plus oxaliplatin or irinotecan in Korean patients

    백, 옥주2011

    … TS, MTHFR-977, XPD-751, GSTP1-105, XRCC1-399, UGT1A1*28 유전자에 대해 분석한 후 다형성에 따라 약제를 선택하여 항암화학치료를 시행하였다. 3주기 시행 후 반응도를 평가하였다. 결과: 44명의 환자가 연구에 참여되었으며 32명의 환자에서 FOLFOX용법으로, 12명의 환자에서 FOLFIRI용법으로 치료받았다. 전체 환자에서 완전관해는 없었으며 맞춤화학치료에 대한 반응율은 43.2%(19명)였다. 유전자 다형성에서 XPD-751, GSTP1-105, XRCC1-399, …

    ajou Repository record

  7. Clinical, pharmacokinetic, and genetic determinants of change in serum creatinine among Southern Africans on dolutegravir based antiretroviral therapy

    Mpofu, RephaimDepartment of Medicine2023

    … -0.53]) and Uridine glucuronosyltransferase 1A1 (UGT1A1) polymorphism rs929596 (β = -2.33 [-4.49, -0.17]; not significant after adjustment for multiple comparisons) were associated with a decreased change in serum creatinine. Conclusion: We identified clinical and pharmacokinetic determinants of …

    cape-town Repository record

  8. SYNTHESIS AND CHARACTERIZATION OF RESVERATROL AND ITS CONJUGATED METABOLITES AND CONTRIBUTION OF METABOLISM TO ITS DECREASED BIOVAILABILITY

    Okpor, Otito IwuchukwuTemple University. Libraries2011

    … genetic polymorphisms in the major enzymes (UGT1A1 and UGT1A6) and rates of glucuronidation of trans and cis-resveratrol. We set out to correlate functional genetic variations in these UGTs with their catalytic rates and a positive association was made for cis-resveratrol and UGT1A6 where the …

    temple Repository record

  9. DNA Damage Induction by Bilirubin Induced Oxidative Stress and Activation of DNA Repair Pathways by Bilirubin

    Rawat, Vipin SinghThe Open University2018

    … Uridine diphosphate-glucuronosyl-transferase A1 (UGT1A1) enzyme present increased levels of total unconjugated bilirubin (UCB) in the blood. When the bilirubin binding capacity of serum albumin is saturated, this results in the increase in the free fraction of bilirubin (Bf). The excess of Bf is …

    the-open-u Repository record

  10. Neonatal Hyperbilirubinemia: <i>in vivo</i> Characterization of Mechanisms of Bilirubin Neurotoxicity and Pharmacological Treatments

    Vodret, SimoneThe Open University2016

    … bilirubin in the brain due to the lack of the Ugt1a1 enzyme. If untreated, mutant mice show neurological deficits leading to early neonatal lethality. The work performed in this Thesis explores three different aspects of bilirubin neurotoxicity: 1. The role of Bf in vivo by the administration …

    the-open-u Repository record

  11. Evaluating Cost Effectiveness of Precision Cancer Medicine Approaches and The Economic Burden of Colorectal Cancer

    Henderson, RaymondQueen's University Belfast2019

    … family 1 member A1 gene (UGT1A1) polymorphism status is not cost-effective in guiding irinotecan dosing.<br/><br/>4.The cost effectiveness of testing of KRAS/NRAS mutational status for guiding cetuximab or panitumumab therapy is inconclusive.<br/><br/>Overall, the …

    qu-belfast Repository record

  12. Pharmacogenomics and pharmacokinetics of dolutegravir and tenofovir in Southern Africans living with HIV

    Cindi, Zinhle AndileDepartment of Medicine2023

    … (AUCVAR), the lowest P-value with AUCVAR was UGT1A1 rs887829 (P = 1.8 x 10-4 ), which was also associated with log10 bilirubin (P = 8.6 x 10-13). After adjusting for rs887829, AUCVAR was independently associated with rs28899168 in the UGT1A locus (P = 0.02), as were bilirubin concentrations (P …

    cape-town Repository record