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Showing 1 to 10 of 10 for “"UGM"”.
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Structural and mechanistic studies on eukaryotic UDP-galactopyranose mutases
… by the enzyme UDP-galactopyranose mutase (UGM), which converts UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf). Solving the mechanism and structure of UGMs will aid in the development of specific inhibitors against these enzymes. Herein we present the detailed functional …
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Permanent Deformation Behaviour of Unbound Granular Materials in Pavement Constructions
… boundary for the unbound granular materials (UGM) was defined for different moisture contents. Below this line the material will have stable behavior. The serviceability limit line was applied in a finite-element (FE)-program FENLAP to predict whether or not stable behavior occurs in the UGM. …
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Comparing Layer Types for the Use of MEPDG for FDR Design
… concrete (AC) and unbound granular material (UGM). Using traffic information from the two Arkansas highways and Arkansas climate data, two different MEPDG models were created for each mixture, one characterizing the FDR layer as an asphalt concrete and the other as an unbound granular …
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"Sugar Coat" Genetic & chemical validation of <i>Aspergillus fumigatus</i> cell wall targets
… UDPGlcNAc. Finally, UDP-galactopyranose mutase (UGM) is the sole source of the galactofuranose sugar that forms short crosslinks in the outer layer of galactomannan.<br/><br/>The underlying hypothesis is that gene deletion of A. fumigatus (i) plant-type chitinases, (ii) GNA1 and (iii) UGM produce …
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Studies of unusual catalysis : a tale of four enzymes from diverse biosynthesis pathways
… pathways. UDP-galactopyranose mutase (UGM) is required for cell wall biosynthesis in many microorganisms. It uses the common cofactor flavin adenine dinucleotide (FAD) in an unusual manner. Positional isotope exchange and kinetic linear free energy relationship studies provide a direct …
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Quantifying Workability, Compactability, and Cohesion Gain of Asphalt Emulsion Cold In-Place Recycling
… procedures for unbound granular materials (UGM), fully bound hot mix asphalt (HMA), and semi-bound asphalt emulsion CIR is presented to establish the current state of mix design for each material type and identify ways the design of asphalt emulsion CIR could become more engineered rather …
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Chemical Probes and Strategies to Study Mycobacterial Cell Envelope Assembly
… strategy to inhibit UDP-galactopyranose mutase (UGM), which catalyzes the committed step in Galf production. To overcome delivery challenges, we designed amide prodrugs activated intracellularly by amidases. One prodrug exhibited improved efficacy in Mtb, providing a promising lead for antibiotic …
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Assessing Working Models' Impact on Land Cover Dynamics through Multi-Agent Based Modeling and Artificial Neural Networks: A Case Study of Roanoke, VA
… landscapes. While existing urban growth models (UGM) offer insights into environmental and economic impacts, There is a need to study the urban phenomena from the bottom-up style, considering the essential influence of individuals' behavior and decision-making process at disaggregate and local …
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Targeting aggregate marginality from a chemical and materials perspective to improve pavement performance
… insight into the water-aggregate interactions of UGM, a testing methodology is devised to determine the real-time appetite of aggregates for water in various environmental conditions. It is concluded that the water absorption of road aggregates depends upon the temperature and composition of the …
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Modellierung des nichtlinear-elastischen Verformungsverhaltens von Tragschichten ohne Bindemittel
Ziel der vorliegenden Dissertation war die Erweiterung der Kenntnisse über das nichtlinear-elastische Spannungs-Verformungsverhalten von Tragschichten ohne Bindemittel (ToB). Ein analytisches Bemessungsverfahren ist aufgrund der schwierigen Modellierbarkeit des Verformungsverhalten der einzelnen …