Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"UDP-galactopyranose mutase"”.
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Structural and mechanistic studies on eukaryotic UDP-galactopyranose mutases
… drug design. Galf is synthesized by the enzyme UDP-galactopyranose mutase (UGM), which converts UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf). Solving the mechanism and structure of UGMs will aid in the development of specific inhibitors against these enzymes. Herein we …
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Studies of unusual catalysis : a tale of four enzymes from diverse biosynthesis pathways
… properties in different biosynthesis pathways. UDP-galactopyranose mutase (UGM) is required for cell wall biosynthesis in many microorganisms. It uses the common cofactor flavin adenine dinucleotide (FAD) in an unusual manner. Positional isotope exchange and kinetic linear free energy …
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Chemical Probes and Strategies to Study Mycobacterial Cell Envelope Assembly
… wall. We employed a prodrug strategy to inhibit UDP-galactopyranose mutase (UGM), which catalyzes the committed step in Galf production. To overcome delivery challenges, we designed amide prodrugs activated intracellularly by amidases. One prodrug exhibited improved efficacy in Mtb, providing a …
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Methods for the Study of Galactofuranose in Mycobacteria
… to produce the rare high-energy sugar donor UDP-galactofuranose in situ for facile preparation of the mycobacterial galactan utilizing the sugar mutase UDP-galactopyranose mutase. We used this method to generate up to 10 milligrams of polymer and demonstrated that it could be selectively …
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"Sugar Coat" Genetic & chemical validation of <i>Aspergillus fumigatus</i> cell wall targets
… (GNA1) an enzyme in the highly conserved UDP-GlcNAc biosynthetic pathway is an elegant means of targeting chitin synthesis upstream by inhibition of the sugar nucleotide substrate UDPGlcNAc. Finally, UDP-galactopyranose mutase (UGM) is the sole source of the galactofuranose sugar that …