Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"UCP2"”.
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
<p>Uncoupling protein 2 (UCP2) is a mitochondrial protein that regulates the flow of protons down the gradient established by the electron transport chain (ETC) without generating ATP, thus uncoupling the proton gradient from ATP generation. In tumors, specifically pancreatic cancer (PDAC), the ETC …
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The use of a genetic strategy to study the role of modulation of oxidative stress by uncoupling proteins 2 and 3 in the pathogenesis of Type 2 Diabetes
… of the effect of genetic variation in the UCP2-UCP3 genetic cluster has so far been inconclusive. The aim of this thesis was to examine, using a genetic strategy, the hypothesis that the role of the uncoupling proteins 2 and 3 in the pathogenesis of Type 2 Diabetes is via modification of …
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… research, we identified uncoupling protein 2 (UCP2) and Sirtuin 3 (Sirt3) as important mediators of the anti-inflammatory phenotype in FABP4 deficient macrophages. Increased expression of UCP2 in FABP4 null macrophages contributes to both suppressed inflammation and endoplasmic reticulum stress …
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Mitochondrial Involvement in Pancreatic Beta Cell Glucolipotoxicity
… and associated cell loss, uncoupling protein-2 (UCP2) protein levels and activity were probed in NEFA exposed INS-1E cells. It is concluded that UCP2 neither mediates palmitate-induced mitochondrial ROS production and the related cell loss, nor protects against these deleterious effects. Instead, …
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Mechanism of action of a tumour derived lipid mobilising factor
… addition, 0.58nM LMF significantly up regulated UCP2 expression (p<0.001), (a mitochondrial protein implicated in the detoxification of ROS) implying this to be the mechanism by which survival was achieved. In vitro, LMF caused significant up-regulation of UCP1 in BAT and UCP2 and 3 in C2C12 …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… treatment is mediated by uncoupling protein 2 (UCP2) activity, and that the effects of IGF-1 treatment can be reversed by UCP2 inhibition. Altogether, these studies implicate nutritionally regulated hormones in promoting CD4+ T cell metabolism and function both in health and disease. </p>
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Investigation of the proteomic interaction profile of uncoupling protein 3 and its effect on epigenetics
… and biochemical functions of the homologs UCP2-5 are still under debate. Our research focuses on UCP3, the homolog prevalently expressed in skeletal muscle (SKM), the most important metabolic organs. UCP3 has long been speculated to have a pivotal role in maintaining the mitochondrial …
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Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases
… These included mitochondrial metabolism (UCP2, PPARɣ, Drp1, Mfn1, Parp 1, Parp2, Sirt3 and Cav3), apoptosis (Bcl2 and Bcl-xL), cardiac electrophysiology and arrhythmia (Scn5a, SERCA2a), calcium handling (SERCA2a) and cardiac remodelling (Myh7, ms1). Melatonin pre-treatment attenuated or …