Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"UCP1"”.
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Structure and regulatory mechanism of human uncoupling protein 1
Uncoupling protein 1 (UCP1) in the mitochondrial inner membrane is responsible for the thermogenic properties of brown adipose tissue. In response to cold exposure, UCP1 is activated by free fatty acids and catalyses proton leak, dissipating the proton motive force, which mitochondria use to drive …
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Function and activation of human adipose tissue: The role of genes in the link between physical activity and brown adipose-like phenotype
… circulating Irisin and uncoupling protein one (UCP1) of WAT in humans (study 1); b) to examine the relationship between UCP1 mRNA and protein expression as well as PGC-1α, peroxisome proliferatoractivated receptor alpha (PPARα) and PPARγ genes with physical activity levels in WAT of healthy men …
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Adrenergic control of proteolysis in brown adipocytes
… proteins, and uncoupling protein 1 (UCP1), the molecular basis for thermogenesis. The overall objective is to gain a better understanding of the control and the mechanisms underlying BAT atrophy. Specific objectives are: (1) whether in vivo patterns of BAT atrophy can be reproduced in …
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Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
… of thermogenic gene, uncoupling protein 1 (UCP1) or the browning of the white adipose tissue (WAT) vs. controls. Next generation RNA sequencing of AhR-CKO vs. control mice liver transcriptomes revealed significantly increased expression of fibroblast growth factor (FGF) 21, a known …
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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
… a significant induction of uncoupling protein 1 (UCP1) in the brown adipose tissue (BAT) of IIA+ mice, suggesting enhanced mitochondrial uncoupling in their adipose tissue to drive this metabolic phenotype. Previous work in Dr. Park’s laboratory suggested that hepatic PLA2G2A expression is …
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Struktur- und Funktionsanalyse der humanen Uncoupling Proteine 1, 2 und 3 (hUCP1, hUCP2 und hUCP3)
… zusätzlich zu dem bekannten Uncoupling Protein (UCP1) im braunen Fettgewebe (BAT) die humanen Uncoupling Proteine 2 und 3 (hUCP2, hUCP3) entdeckt, die in verschiedenen Geweben des Menschen vorkommen. In den Mitochondrien von Nagetieren und Winterschläfern fungiert das Uncoupling Protein 1 als …
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The Isolation and Differentiation of Adipose Derived Mesenchymal Stem Cells
… cultured in medium containing stimulators of UCP1 expression in order to induce a brite cell phenotype. Following a 9 day treatment period, cultures displayed characteristic traits of brite cells such as increased intra-cellular lipid accumulation and increased mitochondrial content. However, …
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Fatty Acid Fate In Determining Oxidation And Inflammation In Adipose Tissue
… the expression of oxidative genes (PCG1á, UCP1 and NOR-1) in WAT of mice, which was greatly potentiated by inhibition of hormone sensitive lipase (HSL). In 3T3-L1 adipocytes, limiting lipolysis potentiated the induction of oxidative genes; while in contrast, promoting the accumulation of …
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Role of Tyk2 in the Development of Beige Cells
… that mRNA expression of BAT-selective genes (UCP1, Cidea, Cox8b, and Elovl3) is significantly reduced in subcutaneous WAT of Tyk2-knockout (Tyk2-/-) mice compared to wild-type mice. Surprisingly, BAT-selective genes are induced in Tyk2-/- subcutaneous WAT by acute starvation. These findings …
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Investigation of the proteomic interaction profile of uncoupling protein 3 and its effect on epigenetics
… Though the prototypical uncoupling protein 1 (UCP1) is known to mediate the cold-induced thermogenesis in rodents and human neonates, the physiological and biochemical functions of the homologs UCP2-5 are still under debate. Our research focuses on UCP3, the homolog prevalently expressed in …
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Exogenous Mitochondrial Transfer and IL-6: Modulating Adipocyte Metabolism in Obesity-associated Dysregulation
… of energy expenditure genes, notably Ucp1, Dio2, Ppara, and Ppargc1a, upon exposure to exogenous mitochondria, thereby promoting a favorable shift in metabolic profiles within white adipocytes. Mitochondria therapy also appeared to stimulate mitochondrial biogenesis through an increase …
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Mechanism of action of a tumour derived lipid mobilising factor
… vitro, LMF caused significant up-regulation of UCP1 in BAT and UCP2 and 3 in C2C12 myotubes. This increase in uncoupling protein expression further potentiates the negative energy balance and wasting observed in cachexia.
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Regulation of Substrate Metabolism and Renin-Angiotensin System with Dietary and Pharmacological Interventions: Implications for Obesity and Related Disorders
… and uncoupled fatty acid (FA) oxidation and UCP1 protein levels in the BAT. These effects could potentially be attributed to the shift to the counterregulatory RAS arm in WAT observed in study 2, which has been shown to produce beneficial metabolic effects. In study 3, the effect of the KD on …
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Candidate Genes for Late Diabetic Complications
… II we demonstrated that polymorphisms in the UCP1-3 genes did not play a major role in the development of micro- or macroalbuminuria in Scandinavian diabetic patients. In study III we showed that a polymorphism in the MHC class II transactivator gene (MHC2TA) was associated with cardiovascular …
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Examination of voluntary wheel running on markers of adipose thermogenesis in intact and ovariectomized female mice
… factor (BDNF) and uncoupling protein-1 (UCP1) in adipose tissue. This study aimed to investigate the effect of voluntary wheel running (VWR) in ovariectomized (OVX) mice on whole body energy expenditure and body composition, key protein markers of thermogenesis and adipose tissue …
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EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… adipocytes markers , such as PRDM16, CIDEA, UCP1, ELOVL3 and DIO2, and an induction of mitochondrial biogenesis, after MS275 administration. In parallel, adypocyte size appeared smaller respect to the adipocytes of the control group. In white adipose tissue, we observed an increase of …
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Dissecting NAMPT Signaling Pathways in Beige Adipocyte Development, Impairment and Maintenance
… signaling. In brown adipose tissue, UCP1-CreERT2–driven NAMPT overexpression preserves thermogenic gene programs, improves cold tolerance and glucose metabolism, and limits adiposity in mice housed at thermoneutrality under a high-fat, high-sucrose diet, despite tissue-level …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
… cells, and increased uncoupling protein 1 (Ucp1) expression, indicating an elevation in thermogenic beige adipose tissue. Cold exposure is the main stimulus for beige adipose tissue activation. It is well understood that the cold activation of beige adipose tissue involves the central …
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Bioenergetic and Metabolic Signatures of Maternal Overnutrition in the Offspring Heart
… Perirenal adipose tissue displayed lowered UCP1 activity, indicative of brown adipose whitening. The mitochondrial effects of the microRNA miR-15b-5p, a prospective molecular mediator of metabolic reprogramming in hearts of obese-exposed adult male mice were assessed in vitro. …
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