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Showing 1 to 13 of 13 for “"UCNPs"”.
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Surface conjugation of upconversion nanoparticles via supramolecular host-guest self-assembly
… science. However, the hydrophobic surface of UCNPs, sometimes, is one of the main challenges for further applications, especially in natural science. It remains a bottleneck for the community to explore practical strategies to functionalize the UCNPs surfaces for hydrophilicity conversion and …
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Anisotropic surface functionalization and applications of upconversion nanoparticles
Lanthanide-doped upconversion nanoparticles (UCNPs) step-wise convert near-infrared adsorbed light into visible emitted light. Monodispersed UCNPs have a large anti-Stokes shift, sharp emission and long excited-state lifetimes. The controlled synthesis of their heterogeneous nanostructures can …
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Upconversion Nanoparticles for pH Sensing and Imaging
… The ability of upconversion nanoparticles (UCNPs) to overcome these challenges through their unique optical properties (NIR excitation, long lifetimes) motivated this work to further the understanding of interactions between particle and pH dye before applying this knowledge to the creation …
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Upconversion quantum yield and luminescence of beta-NaYF4:Yb3+,Er3+ nanoparticles
… (UC) nanometer (nm)-sized particles (UCNPs) exhibit the unique ability to emit one higher-energy photon after the sequential absorption of two or more near-infrared (NIR) photons. This UC luminescence (UCL) makes UCNPs very attractive for the use as optical probes in the biomedical …
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Digital Profiling of Circulating Extracellular Vesicles at Single-Upconversion Nanoparticle Sensitivity and Resolution
… and application of upconversion nanoparticles (UCNPs). In chapter 2, we apply UCNPs for direct enumeration of single CD9 and EpCAM positive EVs (CD9+EpCAM+EVs). The achieved single-molecule sensitivity results in a femtomolar detection limit (1.8 × 106 EVs mL-1), which was nearly 3 orders of …
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Investigation of the energy transfer network in upconverting nanoparticles
Upconverting nanoparticles (UCNPs) have emerged as promising luminescent materials for a wide range of applications, including bioimaging, drug delivery, and photovoltaics. The intricate network of energy transfer processes within UCNPs enables their unique ability to convert low-energy infrared …
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Upconverting nanoparticles: pushing theory and technology towards biomedical applications
… in living tissues. Upconverting nanoparticles (UCNPs) possess the desirable properties of absorbing and emitting NIR light, making them ideal contrast agents for biomedical applications. UCNPs have shown promise in deep tissue imaging, optogenetics, photodynamic therapy, temperature sensing, …
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Identification of bacteria-regulated mechanisms for the pathogenesis of inflammatory bowel diseases (IBD) and development of upconverting nanoparticle (UCNP) luminescence imaging for the monitoring of gut bacteria
… propose to develop upconverting nanoparticles (UCNPs) luminescence imaging for monitoring of gut bacteria. Their unique property of photon upconversion enables them to convert low energy near-infrared (NIR) light into higher energy visible/NIR light offering greater tissue penetrance and …
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Development of Nanoprobes for the Biological Imaging Using Positive Charged Quantum Dots and Upconversion Nanoparticles
… dots (QDs) or upconversion nanoparticles (UCNPs) exhibit interesting properties such as high photoluminescence, photostability, dual magnetic/optical modality. In this study, biocompatible and stable NPs were developed through the various surface modifications. NPs were functionalized by …
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The Design, Synthesis and Characterization of Lanthanide-based Nanomaterials and Their Use in 3D Biological Imaging and Radiation Dosimetry
… emissive bands in upconversion nanoparticles (UCNPs) (2) the development of a 3D imaging modalities that leverage the unique photophysical properties of upconverting nanomaterials and (3) the application of scintillating nanoscale radiation detection materials as an alternative to the …
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EXPLORING HETEROSTRUCTURED UPCONVERSION NANOPARTICLES: FROM RATIONAL PARTICLE ENGINEERING TO BIOMEDICAL APPLICATIONS
… above issues, firstly, asymmetric silica-coated UCNPs were prepared with tunable silica coverage ratio and morphology. On one hand, through stepwise passivation on the asymmetric architecture, the off-on effect at the core-shell interface explicitly indicated the long-neglected significance of …
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Drug Delivery Strategies Using Light Sensitive Molecules
… a drug conjugate that would be attached to UCNPs. We envision that after grafting the drug conjugate onto the nanoparticles and irradiating it with NIR drug release will occur as a result of upconversion. The above two systems describes novel methodologies for controlled release of the drug. …
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In vitro selection of DNAzymes selective for monovalent metal ions and their development as sensors in living cells and organisms
… lanthanide-doped upconversion nanoparticles (UCNPs), a deep tissue penetrating NIR light was converted into 365 nm emission for DNAzyme sensor activation and metal ion detection. Genetically encoded fluorescent proteins (FPs) have been applied for metal ion detection but restricted to a …