Global ETD Search
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Showing 1 to 3 of 3 for “"UCHL5"”.
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Characterizing The Role of Uchl5 In Metastatic Melanoma
… to identify potential drivers of metastasis. UCHL5/UCH37 was identified as one of the top candidates. UCHL5 is a deubiquitinating enzyme and interacts with the 26S proteasome complex and the INO80 chromatin remodeling complex. While UCHL5 has been shown to be overexpressed in many cancers, it …
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Structural and biophysical analysis of the proteasomal deubiquitinase, UCH37
… believed to be autoinhibited by its C-terminal UCHL5-like domain, or ULD, which may also be responsible for its oligomerization in solution. This work examines the structural, biophysical, and catalytic characteristics of UCH37 in order to elucidate its mechanism of activation by Rpn13, assess …
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Cellular Determinants Of AURKA Degradation By Small Molecule Proteolysis-Targeting Chimeras
… PROTAC-opposing activity of the proteasomal DUB UCHL5 against both AURKA and dTAG PROTACs that is independent of the substrate tested but specific to CRBN-recruiting dTAG PROTACs. I also explore the PROTAC-independent role of OTUD6A in regulating AURKA stability and function in the cell cycle, by …