Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"UCHL1"”.
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Cyclin B1 Mediates The Effect of Uchl1 In Promoting Cell Cycle Progression In Uterine Papillary Serous Carcinoma
… Ubiquitin Carboxyl-Terminal Hydrolase L1 (<em>UCHL1</em>) to be a gene of interest, as it was significantly upregulated in UPSC and correlated with poorer overall survival. These findings were validated through immunohistochemical analysis of an independent cohort of tumor samples. Due to its …
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UCHLI in the Mammalian Nervous System
UCHL1, or Ubiquitin Carboxy Terminal Hydrolase L1, is a de-ubiquitinating enzyme (DUB) thought to be involved in ubiquitin recycling. Beyond this, its natural function is almost wholly unknown. Mice lacking this enzyme exhibit a severe and rapidly progressing neurodegenerative phenotype. Using one …
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The role of UCH-L1 in mouse progenitor spermatogonia
… demonstrated that over time, in the absence of UCHL1, the spermatogonia pool expands at the expense of differentiation. Additionally, RNA sequencing of Uch-l1+/+ and Uch-l1-/- spermatogonia showed that the Uch-l1-/- spermatogonia have a gene expression profile closer to that of undifferentiated …
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Neuroprotective effects of the dual glycogen synthase kinase-3b and phosphodiesterase 7 inhibitor VP3.15 and of an enriched environment in germinal matrix-intraventricular hemorrhage
… such as ubiquitin carboxyterminal hydrolase L1 (UCHL1) and p-GSL, in treated animals. In parallel, plasma levels of GFAP, NfL and UCHL1, decreased over time in controls and in patients with GM-IVH. Notably, plasma tau levels, a marker of neuronal damage, were significantly reduced in those …