Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"UBP3"”.
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On aging and the role of Ubp3 in heterochromatic gene silencing and protein quality control
… was directed towards the deubiquitinating enzyme Ubp3 which had already been shown to be tightly linked to regulation of transcription and proteome surveillance, both of which are essential in cells adaptation to stress. In this thesis, I show that cells lacking Ubp3 are short-lived despite …
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Global and chromosome-specific consequences of aneuploidy in Saccharomyces cerevisiae
… Additionally, we identify a deubiquitinase, Ubp3, whose deletion broadly impairs aneuploid yeast cell fitness via both karyotype-dependent and karyotype-independent mechanisms. Deletion of UBP3 severely exacerbates proteotoxicity in aneuploid yeast and impairs proteasome function. Indeed, our …
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The Role of Arabidopsis thaliana P80 in Inositol Signaling
… WDR20 and Ubiquitin-specific protease called UBP3. Our p80 mutants have a root deficient phenotype under low energy conditions which is normalized by addition of sucrose. p80 mutants show reduced growth and early senescence under specific environmental conditions. This is opposite in nature to …
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Molecular analysis of vesicle biogenesis during autophagy
… cerevisiae. The ubiquitin deconjugation enzyme Ubp3 and its cofactor Bre5 are also required for PMN but not for the Cvt-pathway or autophagy. The vps class E genes vps27 and vps28 are also exclusively required for PMN. So far the fusion of the edges of double-membrane structures leading to …