Global ETD Search
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Showing 1 to 4 of 4 for “"UBE4B"”.
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Characterization of The Ubiquitin Ligase, Ube4B, In Endocytic Trafficking
… have identified a protein interaction between UBE4B, an E3/E4 ubiquitin ligase, and the ESCRT-0 components, Hrs and STAM. ESCRT-0 is the first complex of the endosomal sorting machinery to bind to endosomes, and recognition by ESCRT-0 is required for EGFR sorting and degradation. …
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The Ubiquitin Ligase Ube4B Is Required For Efficient Epidermal Growth Factor Receptor Degradation
… to recruit and bind an E3 ubiquitin ligase, UBE4B, to endosomes. In an assay that is able to measure cargo movement, the disruption of the Hrs-UBE4B interaction showed impaired sorting of EGF receptor into MVBs. My hypothesis is that UBE4B may be the connection between MVB sorting and …
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Ube4B Levels Determine The Efficacy of Egfr and Stat5 Inhibitors In Treatment Resistant Neuroblastoma
… provide a mechanism for chemotherapy resistance. UBE4B, an E3/E4 ubiquitin ligase, ubiquitinates the EGFR and promotes its lysosomal degradation ultimately attenuating EGFR signaling. Interestingly, the UBE4B gene lies in a chromosomal region (1p36) whose loss is correlated with poor patient …
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Endocytic Trafficking of The Amyloid Precursor Protein In Rat Cortical Neurons
… the endosome-associated E3 ubiquitin ligase, UBE4B, is required for efficient endosomal APP trafficking. These results suggest that the efficiency of endosomal APP trafficking regulates Aβ generation. Decreasing Aβ levels in the brain may be a mechanism for disease modification in …