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Showing 1 to 2 of 2 for “"UBE2L6"”.
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ISG15 conjugation : cellular targets and the lysine selectivity of HERC5
… modifier. Like ISG15, the human E1 (UBE1L), E2 (UBE2L6) and E3 (HERC5) enzymes for ISG15 are all induced at the transcriptional level by type I IFN. ISGylation of pathogen and host proteins is a component of cellular defense against viruses. Consistent with this, many viruses have evolved …