Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"UBE2C"”.
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Investigating The Interaction of Aurka and Ube2C In Colorectal Cancer Cells
… the signature, the ubiquitin conjugating enzyme UBE2C, was identified through preliminary bioinformatics analysis as a candidate for further examination of its role in CRC progression. Co-expression analysis of UBE2C in tumor-normal datasets from the public database Oncomine revealed all the …
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Enhanced protein degradation by branched ubiquitin chains
… by the ubiquitin-conjugating enzyme E2 C (Ube2C). Therefore, I identified an enzyme and substrates for modification with branched ubiquitin chains, which points to an important role of these conjugates in providing an improved signal for proteasomal degradation. Compared to homogenous …
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Phopsphorylation and Ubiquitin Modification At Dna Damage Sites In Response to Double-Strand Breaks
… damage sites in an ATM-dependent manner by Ube2S/Ube2C E2 conjugating and RNF8 E3 ligase enzymes and deubiquitinated by OTUD7B (Cezanne) enzyme. I further showed that histones H2A and H2A.X is modified with Lys11-linked polyubiquitination in a DNA damage-dependent manner that is essential for …