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Showing 1 to 13 of 13 for “"UBA."”.
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STRUCTURAL AND FUNCTIONAL STUDIES OF CYCLIC K48-LINKED DIUBIQUITIN
… are involved in binding to ubiquitin-associated (UBA) domains. Cyclization of K48-Ub2 should limit the range of conformations available for such interactions. Interestingly, cyclic K48-linked Ub2 (cycUb2) has been found in vivo and can be isolated in vitro to study its structure and dynamics. In …
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Characterizing Multivalent Interactions Between Folded Protein Domains and Intrinsically Disordered Regions or Peptide Substrates
… (UBL) and C-terminal ubiquitin associated (UBA) domains, respectively. UBQLN2 forms liquid droplets in vitro via a biophysical mechanism called liquid-liquid phase separation. We found that UBQLN2 LLPS is mediated by its middle intrinsically disordered region (IDR). The two folded domains of …
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Der plasmamembran assoziierte Transportregulator RS1 bindet Ubiquitin und gelangt in den Zellkern
… AS 579 bis 616 eine Ubiquitin associated domain (UBA) identifiziert werden, die auch in den anderen bisher bekannten RS1-Proteinen aus Mensch, Kaninchen und Maus konserviert vorliegt. Eine Ubiquitin-Affinitätschromatographie zeigte, dass das pRS1-Protein Ubiquitin auf nicht kovalente Weise bindet. …
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Molekulare und funktionelle Analyse des Gens rings lost (CG4420) in der Entwicklung von Drosophila melanogaster
… (UBQ)- und Ubiquitin-assoziierte (UBA)-Domäne die typische Struktur eines extraproteasomalen Polyubiquitinrezeptors auf. In dieser Arbeit konnte gezeigt werden, dass Rngo genau wie andere extraproteasomale Polyubiquitinrezeptoren an das Proteasom sowie, vermittelt durch seine …
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Characterisation of the KA1 & KA2 domains and interaction with APC/C
… the role of the ubiquitin associated (UBA) domains in the S. pombe shuttle factor Rhp23. This protein can recognise the proteasome via an ubiquitin like (UBL) domain and ubiquitin chains via one of two UBA domains: an internal UBA1 and a C-terminal UBA2. To dissect the different …
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Dual Roles for NBR1 in Bone Remodelling and Autophagosomal Protein Degradation
… protein-protein interactions. The C-terminal UBA domain of Nbrl binds mono- and polyubiquitinated chains whilst the N-terminal PB1 domain interacts with the structurally similar protein p62. The aims of this thesis were to further characterise the biological functions of Nbrl by identifying …
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The creation of the European Environment Agency and its impact on national administrations in Germany, France and Britain
… This thesis assesses the German Umweltbundesamt (UBA), French Agence de l’Environnement at de la Maîtrise de l’Energie (ADEME) and Institut Français de l’Environnement (Ifen) as well as the Environment Agency (EA) of England and Wales. The different national arrangements for Eionet participation …
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Public health impacts of excess NOx̳ emissions from Volkswagen diesel passenger vehicles in Germany
… the German Environmental Protection Agency's (UBA) estimate of the spatial distribution of NOx emissions from passenger cars in Germany. I use the GEOS-Chem chemistry-transport model to predict the corresponding increase in population exposure to fine particulate matter and ozone in the …
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The p97 cofactors UBXN7 and UBXN8 interact with and modulate the function of cullin-RING complexes and Fanconi anaemia proteins FANCD2/FANCI, respectively
… proteins, UBXN7 and UBXN8.<br/><br/>Among human UBA-UBX proteins, UBXN7 is the most proficient in interacting with CRL (cullin-RING E3 ligase) subunits, in particular CUL2, and it was assumed that these interactions were indirect, mediated by ubiquitylated substrates. However, we show that UBXN7 …
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Fettsucht mit erhöhter D-Glukose-Absorption im Dünndarm durch Inaktivierung des Regulatorproteins RS1 bei Mäusen
… fähig Ubiquitin über eine Ubiquitin-assoziierte (UBA) Domäne zu binden. Es reduziert die Konzentration einiger Proteine in der Plasmamembran. Durch Expressionsversuche in Xenopus Oozyten wurde gezeigt, dass RS1 die Menge des Na+-D-Glukosekotransporters SGLT1 in der Plasmamembran …
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Using DNA markers to trace pedigrees and population substructure and identify associations between major histocompatibility regions and disease resistance in rainbow trout (Oncorhynchus mykiss)
… linkage map. A general relationship between UBA gene sequence types and MH-IA-linked microsatellite alleles indicated that microsatellites mapped near or within specific major histocompatibility (MH) loci reliably mark sequence variation at MH genes. The parents and grandparents of the 2005 …
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Comparative Life Cycle Assessment of CFC-replacement Compounds in Different Technical Applications
… or non-assessable substances in drinking water (UBA 2003). Assuming that all 46 million German passenger cars (Destatis 2006a) are equipped with A/C systems using E7000, E7100, or E7200, the concentration of the degradation products in German surface waters will amount to 0.1 – 1 µg/L. That means …
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Why bowl? Exploring competitive bowlers' experiences and perspectives within bowling associations : a multiple case study.
The sport of bowling encompasses recreational, youth, competitive, amateur, collegiate, and professional bowlers. Although researchers have investigated motivations that influence individuals to participate in the sport, studies have not separated experiences by the aforementioned type of bowler …