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Discrete elements of the U2 snRNP regulate its intranuclear trafficking and recruitment to nascent transcripts

Paschedag, JoshuaUniversity of Illinois at Urbana-Champaign2012

… SL4, I further show that the associated protein U2B” rather than SL4 itself provides the targeting activity, which establishes a critical new role for U2B” in the pre-mRNA splicing pathway. Additionally, I demonstrate that a lack of SL3, SL4, or U2B” results in an accumulation of the U2 snRNP …

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