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Showing 1 to 4 of 4 for “"U18666A"”.
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Cationic amphiphilic drug-induced autophagosome accumulation is due to autophagosome sequestration within vimentin intermediate filament networks resulting in prolonged autophagosome half-life
… to the cationic</p> <p>amphiphilic drugs (CADs) U18666A, imipramine and clozapine caused</p> <p>lysosomal non-esterified cholesterol and autophagosome accumulation.</p> <p>Measurement of LC3-II conversion in the presence of lysosomal inhibitors</p> <p>bafilomycin A1 and NH4Cl, degradation of …
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Graphene Brain on a Chip Platform for the Study of Neurodegeneration
… the imaging and electrophysiology data. Using U18666A to induce Niemann-Pick disease type C, the graphene MEAs and methodology for simultaneous imaging and electrophysiology were validated. It was found that U18666A had a significant degenerative impact on the synchronicity, activity, …
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The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.
… esters. An inhibitor of cholesterol trafficking, U18666A, specifically prevented the accumulation of cholesteryl esters, but not 7-ketocholesteryl esters nor the induction of apoptosis. An inhibitor of cPLA<sub>2</sub> prevented the accumulation of 7-ketocholesteryl esters. This inhibition was …
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Exosomes act as molecular vehicles contributing to cellular cholesterol efflux
… von Cholesterin wird dabei durch die Chemikalie U18666A oder durch Verringerung der Proteinsexpression von NPC1 mittels siRNA hervorgerufen. Eine vergleichbare Steigerung der Exosomensekretion lässt sich auch für die primären Fibroblasten ei! nes NPC-Patienten nachweisen. Weiterhin führt die …