Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"U0126"”.
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U0126, MEK1/2 inhibitor, Induces Adhesion Molecules Expression in Human Blood Cells
… adhesion molecule by MEK1/2 inhibotors such as U0126 in human blood cells, U937 cells. Cell viability was determined by MTT assay. The expression of adhesion molecule was observed by flow cytometry. Adhesion molecules were time- and dose-dependently incresed by U0126. U0126 decreased ERK …
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A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death
… pro-survival signaling with the MEK inhibitor U0126 rescued the C4-2 cells from resveratrol-induced death, however other MEK inhibitors did not recapitulate this response. In fact, U0126 acted independently of MEK, inhibiting mitochondrial function and shifting cells to aerobic glycolysis. …
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Intracellular Signaling Contributions to Behaviors Relevant to Nicotine Addiction
… cingulate cortex (PFC). ERK kinase inhibitor U0126 was infused in the NAc shell or PFC of Long Evans rats immediately prior to daily self-administration sessions and following 8+ days of abstinence. U0126 in the PFC decreased responding for nicotine during daily sessions. Following 8+ days of …
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Angiotensin Type-2 (At2) Receptor Modulation of Nmda-Mediated Current, Signaling and Apoptosis
… of ERK with MEK inhibitors (PD98059 and U0126) significantly decreased PARP cleavage (cPARP), while inhibition of PP2A with 10 nM okadaic acid, significantly increased NMDA-mediated cPARP expression. Further, we demonstrate that the AT2 receptor attenuates NMDA-mediated subunit …
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Regulation of acid-stimulated H+ secretion by Pyk2 and MAPK signaling pathways in the outer medullary collecting duct
… Src phosphorylation, and the MEK inhibitor U0126 to inhibit ERK1/2 phosphorylation. Furthermore, we used adenoviral-gene transfer of AdCRNK, a dominant-interfering truncated Pyk2 construct, to block Pyk2 phosphorylation at Tyr402 as well as the p38-specific inhibitor, SB203580. The …
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Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
… with selective inhibitors of MEK1/2 (PD98059/U0126) PI3K (LY294002) and TrkA (GW441756) and phosphorylation of target kinases. Associated factors namely, acetylation of histones (H3/H4) and α-tubulin, role of cAMP, and cell- cycle analysis with flowcytometry were also studied. </p> …
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Pharmacological effect of MEK inhibitors on plasmodium falciparum
… MEKs, it had been shown in our laboratory that U0126, a MEK inhibitor, had parasitocidal activity in vitro. To confirm and extend these data, a panel of structurally distinct MEK inhibitors, most of which are not ATP competitors (and hence are likely to be more selective than more classical PK …
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Effects of Cadmium on VCAM-1 Expression
… 억제제 (SP600125)는 VCAM-1의 발현증가를 억제시킨 반면, ERK 억제제 (U0126)는 발현증가에 아무런 영향을 미치지 못하였다. 이 결과로 보아 카드뮴은 p38 MAPK와 JNK의 인산화를 경유하여 뇌혈관 내피세포의 VCAM-1의 발현을 증가시키는 것으로 생각된다. "
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Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
… fibronectin (FN), while inhibition of MEK/ERK by U0126 had no effect. Microscopy showed that RAF inhibition leads to significant inhibition of T cell spreading on VCAM-1. The association of α4β1 integrin with the actin cytoskeleton was shown to be dependent on B-Raf activity or expression, while …
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Studies on the Roles of PDGFRA and EGFR in the Classification and Identification of Therapeutic Targets for Human Gliomas
… tumor samples. We also found that MEK inhibitor U0126 treatment can decrease the surface PDGFRA expression and result in deviation of PDGFRA from endosomal trafficking and recycling compartment to the Golgi network in a reversible, dose- and time-dependent manner without affecting total PDGFRA …
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Estrogen Signaling in Trigeminal Nociception
… We stereotactically administered ERK antagonist U0126, or inactive control U0124, to the trigeminal ganglion of CFA+E2-treated rats. U0126 decreased withdrawal responses to mechanical stimulation of the whisker pad compared to U0124-treated rats. Because the secondary allodynia in V2 after …
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Effects of phosphatidylinositol on ApoA-I metabolism: Implications in HDL metabolism
… apoA-I secretion, the MEK1/2 inhibitor U0126 blocks PI-induced apoA-I secretion. Inhibition of the JNK MAPK pathway by SP600125 also blocks PI mediated apoA-I secretion. Real-time PCR shows no changes in cellular apoA-I mRNA and suggests that PI is not impacting the transcription of the …
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Regulation of SRC-3 localization and dynamics by phosphorylation during ERα-dependent transcriptional activation
… we show that both chemical inhibition (with U0126) and siRNA downregulation of the MAP/ERK1/2 kinase (MEK1/2) pathway induce a cytoplasmic shift in SRC-3 localization, whereas stimulation by EGF signaling enhances its nuclear localization by inducing phosphorylation at T24, S857, and S860, …
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Molecular mechanisms involved in the anticancer activity of BISPMB in oesophageal cancer cells
… On the other hand, inhibition of ERK1/2 MAPK by U0126 enhanced the anti-proliferative effect of bisPMB in WHCO1 cells. These results support the hypothesis that ER stress and MAPK signalling pathways are essential for bisPMB induced cytotoxicity in oesophageal cancer cells.
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Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
… inhibited by MAP kinase inhibitors SB203580 and U0126, thus suggesting that the SCFA effect may be mediated by orphan G-protein receptors GPR41 and GPR43. S. typhimurium induced SPRR2 in undifferentiated cells. We conclude that SPRR2 protein expression is associated with differentiated epithelia …
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GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT
… Only after intraperitoneal treatment of U0126, an inhibitor of ERK phosphorylation, was lens development restored in Nf1 mutants. Hyperactive RAS-MAPK signaling is known to cause neuro-cardiofacial-cutaneous (NCFC) syndromes in human. As a member of NCFC family genes, Nf1 represents the …
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The Effect of L-DOPA and Natural Products on Age-Related Motor Deficits and Dopaminergic Cell Survival
… ERK1/2, but not ERK5. Pretreatment with U0126, an inhibitor of the ERK1/2 pathways, blocked the resveratrol- and pinostilbene-mediated neuroprotection. </p><p> Together, these data suggest that resveratrol, pinostilbene, and/or WBB may decrease age-related motor deficits by protecting DA …
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The Transcription Factor ATF5 Protects Cortical Neurons from Toxicity Induced by Prostaglandin J2
… signaling pathway with the selective inhibitor U0126 revealed yet another level of anti-apoptotic regulation by ATF5. A blockade of ERK activation prevented the protection by ATF5 by increasing the loss in cell viability induced by PGJ2. These findings suggest that ERK activation plays a role in …
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Modulation of the response to cisplatin by nitric oxide and reactive oxygen species in melanoma cells
… the remarkable ability to overcome the effect of U0126, a MEK inhibitor, and promoted continuous phosphorylation of ERK1/2 (and hence cell survival), in contrast to cells not exposed to NO. Results also demonstrated that cisplatin-induced apoptosis was substantially decreased by the antioxidant …
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LncRNA and circRNA expression profiles in tissues and serum exosomes of colorectal cancer patients and cell lines
… UCA1 in HCT-116 colon cancer cells treated with U0126 (MEK1/2 specific inhibitor) compared to untreated cells, suggesting a possible connection between ncRNAs and MAPKs. Also, we performed a computational analysis to identify mRNAs and miRNAs involved in CRC and characterized by correlation of …
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