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Showing 1 to 12 of 12 for “"Tyrphostin"”.
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Tyrphostin AG126 modulates Toll-like receptor (TLR) activation-induced functions in microglia by protein tyrosine kinase (PTK) -dependent and -independent mechanisms
Tyrphostine stellen eine Klasse synthetischer Protein-Tyrosin-Kinase (PTK)-Hemmer, die sich strukturell vom Tyrosin ableiten und dazu dienen, spezifisch Substratphosphorylierungen zu verhindern. Tyrphostin AG126 zeigte entzündungshemmende Eigenschaften in zahlreichen Tiermodellen von Erkrankungen. …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… kinase, thereby suppressing tumor cell growth. Tyrphostin AG490, the first described Jak2 inhibitor, displays poor pharmacology and requires high concentrations for anti-tumor activities. Our research group screened a small library of AG490 structural analogues and identified WP1130 as a potent …
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Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
… (RpcAMPs); and tyrosine kinase inhibitor tyrphostin. We observed that histamine augmented the phosphorylation of STAT1 through both HI and H2 receptors. Furthermore, HI and H2 receptor antagonists displayed inverse agonism whereby HI inverse agonists inhibited the phosphorylation of STAT1 …
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Einfluss der Neurotransmitter PACAP und VIP auf die Aktivität der Mitogen-aktivierten Proteinkinase in Astrozyten
… Den hemmenden Effekt des EGF-Antagonisten Tyrphostin vermochte VIP weiter zu ver-stärken. <br>Da VIP die hemmenden Wirkungen auf die MAPK bereits in nanomolaren Konzentratio-nen gezeigt, ist anzunehmen, dass diese Effekte über die VPAC1/VPAC2-Rezeptoren verlaufen. Die bedingungsabhängige …
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Regulation of STAT6 and STAT4 Phosphorlation by Histamine
… of STAT4 and STAT6. Tyrosine kinase inhibitor, tyrphostin, inhibited the histamine mediated STAT6 phosphorylation whereas it did not affect the STAT4 phosphorylation. Histamine augmented the IL-4 induced phosphorylation of STAT6. The effects of histamine on the STAT6 phosphorylation were …
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Mechanisms of ion channel activation in primary cultured and clonal cell lines
… of protein kinase (A (H-89) and tyrosine kinase (tyrphostin A25), and could not be mimicked by elevation of intracellular Ca2+ or activation of protein kinase C. Similarly, disruption of actin filaments by dihydrocytochalsin B, or generation of membrane tension by dipyridamole failed to elicit …
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The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… The inhibitors of JAK/PI3K/PDE3B respectively Tyrphostin AG490, LY-294002, and 3-isobutyl-lmethylxanthine reversed the inhibitory effect of G-CSF on corticosterone synthesis. We report that G-CSF was neuroprotective in neonatal HI by reducing infarct volume, by suppressing the HI-induced …
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Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… The inhibitors of JAK/PI3K/PDE3B respectively Tyrphostin AG490, LY-294002, and 3-isobutyl-1methylxanthine reversed the inhibitory effect of G-CSF on corticosterone synthesis. We report that G-CSF was neuroprotective in neonatal HI by reducing infarct volume, by suppressing the HIinduced …
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Regulation des Neuritenwachstums durch Rho-GTPasen in primärkultivierten Hippocampusneuronen der Ratte
… mit den Tyrosin-Kinase-Inhibitoren Genistein und Tyrphostin 47 <br>eine Beteiligung eines Rezeptors vom Tyrosin-Kinase Typ und dessen Liganden nahe. <br>Dass es sich hierbei um Insulin handeln könnte, wird experimentell gezeigt. <br>Außerdem wird gezeigt, dass auch die Inhibition der p38MAP-Kinase …
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Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation
… (7,8-DHF), and TrkB antagonists; genistein, tyrphostin 23, and K252a, on DA dynamics in the CPu of brain slices obtain from BDNF deficient (BDNF+/-) mice and their wildtype littermates. Overall, the results obtained highlighted the utility of FSCV to probe the functional effect of Trk …
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Naturstoff-basierte Cytostatika mit verbesserter Tumorselektivität und Potential zur Überwindung von Wirkstoffresistenzen
… oder zwei Rezeptortyrosinkinase-inhibierenden Tyrphostin-Derivaten. Ein weiteres Projekt war die Synthese von Metallkomplexen mit Melophlinen, einer Familie mariner N-Methyl-3-acyltetramsäuren. Melophlin C wurde mit geeigneten Metall-Fragmenten zu den entsprechenden Metallkomplexen umgesetzt, …
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Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells
… with TNF- a. Pre-treatment of cells with tyrphostin AG490 resulted in appearance of SOCS3 upon treatment of cells with IGF-i together with TNF-a. These novel findings suggest that SOCS3 expression in hCASMCs regulates the activity of IGF-l signaling. This leads to decreased cell …