Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Tyrosine Kinase Inhibition"”.
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EGFR in Early Non-small Cell Lung Cancer: Tyrosine Kinase Inhibition in a Neoadjuvant Trial
EGFR TKIs are standard therapy for advanced NSCLC. In order to define their role in early disease, we implemented a phase II trial of neoadjuvant gefitinib in clinical stage I NSCLC. Tumour shrinkage was seen in 43% of patients, with 11% achieving RECIST partial response (PR). Analysis of molecular …
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… of resistance to EGFR-targeted small molecule tyrosine kinase inhibitors (TKIs). Specifically, we have shown that EGFR localizes to discrete membrane microdomains (lipid rafts) in cell lines that are resistant to EGFR TKI-induced growth inhibition. Depletion of lipid rafts via cholesterol …
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Tyrosinkinaseinhibition bei humanen Non-Hodgkin-Lymphomen: Präklinische Evaluation von Sorafenib
… mit kurativem Potential zur Verfügung. Kinase-vermittelte intrazelluläre Signalübermittlung ist entscheidend für das Überleben von Lymphomzellen, wobei bisher in der Pathogenese der malignen Lymphome in der Regel mehrere, z.T. überlappende Signaltransduktionswege als aktiviert …