Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1052 for “"Tyrosine"”.
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Towards the Characterization of Enzymes Involved in the Metabolism of Tyrosine and Tyrosine Derivatives
Tyrosine is involved in many biological processes including protein synthesis. This dissertation is focused on two different aspects: tyrosine catabolism and tyrosine derivative metabolism. Tyrosine undergoes degradation via tyrosine aminotransferase (TAT). Deficiency of TAT leads to some disease …
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Tyrosine Sulfation in A431 Cells
… I have identified and characterized a unique tyrosine sulfotransferase and its substrate in A431 cells. I also established an in vitro assay method for tyrosine sulfotransferase activity, which opened a door towards enzyme purification Sulfation of proteins on tyrosine residues has recently …
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The receptor tyrosine phosphatase Ptp69D and the receptor tyrosine kinase Pvr in Drosophila nervous system development
… migration in Drosophila. Ptp69D is a receptor tyrosine phosphatase required for axon guidance in the developing embryo and for layer-specific axon targeting in the developing visual system. Using a dominant-negative form of Ptp69D, I have identified several genes with which Ptp69D genetically …
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Mass Spectrometric Analysis of Tyrosine Metabolic Enzymes
The metabolism of tyrosine is essential for many critical biochemical events including catecholamine synthesis, melanogenesis and insect cuticle sclerotization. These pathways are highly regulated in both insects and mammals by many well-characterized enzymes including dopa decarboxylase and …
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Redox active tyrosine residues in biomimetic beta hairpins
… interactions control the redox properties of tyrosine in enzymes. The data in this study demonstrate that proton transfer to histidine, a hydrogen bond to arginine, and a pi-cation interaction create a peptide environment that lowers the midpoint potential of tyrosine in beta hairpins. …
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Tyrosine Kinase Inhibitors in Triple Negative Breast Cancer
… inhibitors in TNBC, including the small molecule tyrosine kinases inhibitors of EGFR gefitinib and erlotinib, the monoclonal antibody against EGFR cetuximab, and the multi-target tyrosine kinase inhibitor dasatinib. Significantly higher EGFR expression was detected in TNBC compared to HER-2 …
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Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases
… factor receptor: EGFR) is a membrane receptor tyrosine kinase whose over-activation has been implicated to cause many human cancers. Novel strategies to inhibit the activation of EGF receptors other than the conventional antibody-based and tyrosine kinase inhibitors are virtually non-existent …
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Specificity of SH2 domains and protein tyrosine phosphatases
… by receptors that are themselves protein tyrosine kinases (PTKs) or have an associated PTK activity. SH2 domains and protein tyrosine phosphatases (PTPs) play essential roles in transmitting these signals. SH2 domains are small domains of V100 amino acids that bind to phospho-tyrosine (pY) …
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Tyrosine Activation and Transfer to Soluble Ribonucleic Acid
Made available in DSpace on 2014-12-05T19:38:14Z (GMT). No. of bitstreams: 1 6305093.pdf: 4472825 bytes, checksum: 03943b358caefae2198cc8789b4ed908 (MD5) Previous issue date: 1963
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Histone modification during the induction of tyrosine transaminase
"The induction phenomenon is a useful model for the study of mechanisms which regulate the synthesis of specific enzymes in mammalian tissue, as well as for the role of hormones in this process". The in vivo administration of hormone initiates a chain of reactions which culminate in the increase of …
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CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… receptor (PDGFR), crenolanib, as examples of tyrosine kinase inhibitors currently tested for treatment of malignant glioma. Given the poor microdialysis probe recovery of these lipophilic molecules, we enhanced their recovery by including an affinity-based trapping agent, 10% …
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Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders
… have highlighted the importance of aberrant tyrosine kinase signalling in the pathogenesis of these disorders. Cloning of rare chromosomal translocations and point mutation analysis in the MPDs has identified diverse deregulated tyrosine kinase genes, notably PDGFRA, PDGFRB, FGFR1 and JAK2. …
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Probing Isoforms of the Prion Protein through Tyrosine Nitration
… mass spectrometry, are reported. Two conserved tyrosine residues (tyrosines 149 and 150) are not labeled by either reagent in the normal cellular form of the prion protein but these residues become reactive after the protein has been converted to one of two aggregated isoforms. Another …
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Probing Isoforms of the Prion Protein through Tyrosine Nitration
… mass spectrometry, are reported. Two conserved tyrosine residues (tyrosines 149 and 150) are not labeled by either reagent in the normal cellular form of the prion protein but these residues become reactive after the protein has been converted to one of two aggregated isoforms. Another …
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The Soluble Form of the Axl Receptor Tyrosine Kinase
… receptor Axl, which is a member of the receptor tyrosine kinase family. Axl is activated by the ligand Gas6 inducing cell growth and proliferation, but also regulate inflammation and vascular homeostasis. The Axl receptor can be cleaved outside the membrane, releasing the extracellular, soluble …
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Bruton's tyrosine kinase regulator of innate and humoral immunity
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Regulation of cell motility by Shp-2 tyrosine phosphatase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The biosynthesis of brominated tyrosine metabolites by Aplysina fistularis
The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. ($U$-$\sp{14}$C) -L-Tyrosine, ($U$-$\sp{14}$C) -L-3-bromotyrosine, and ($U$-$\sp{14}$) -3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol and aeroplysinin-1, and …
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