Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 298 for “"Typhimurium"”.
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Genetic duplication in Salmonella typhimurium
A gene duplication occurs in Salmonella typhimurium which involves about 30% of the genome. The frequency of formation and loss of this duplication was determined in a Rec.A⁻ strain and a PolA⁻ strain and compared to that of a RecA⁺, PolA⁺ strain. The frequency of formation was found to be reduced …
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Oxygen Regulated Genes in Salmonella Typhimurium
… leucine and casamino acids, showed that S. typhimurium produced propionate from threonine.
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Inflammasome signalling during Salmonella Typhimurium infection
… bacteria such as Salmonella enterica serovar Typhimurium express a range of bacterial PAMPs recognised by Toll-like receptors (TLRs) including lipopolysaccharides (LPS) recognised by TLR-4 and lipoproteins by TLR-2. The activation of TLRs results in activation of nuclear factor κB (NF-κB) to …
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The Mechanism of Aerotaxis in SALMONELLA TYPHIMURIUM
… to other chemotaxis pathways in <em>Salmonella typhimurium</em> was explored with the aid of two new assays which imposed an oxygen gradient independently of bacterial respiration. In the spatial assay, bacteria accumulated at the mouth of an oxygen-filled capillary. In the temporal assay, cells …
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Extracytoplasmic stress response systems in S. Typhimurium
… thesis was to characterise the ESR systems of S. Typhimurium to widen our current knowledge of genes involved in these systems and their role in the pathogenesis of S. Typhimurium with the ultimate aim of identifying possible candidate vaccine genes that may be used in future therapeutics against …
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Antibody Response to Lipopolysaccharide of Salmonella Typhimurium
… mAbs in mice challenged with virulent S. typhimurium. Therefore, a subtle modification of O-Ag such as acetylation has a profound effect on the host immune response.
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Gene Regulation of Tartrate Metabolism in Salmonella typhimurium
Salmonella Typhimurium (S. Tm) triggers an inflammatory response in the gut that favors the outgrowth of the pathogen over the resident microbiota. Early in S. Tm infection, oxidation of simple sugars by reactive nitrogen and oxygen species gives rise to L- and D-tartrate, which support fumarate …
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The Role of CheV in S. typhimurium Chemotaxis
… systems of Escherichia coli and Salmonella typhimurium are thought to be virtually identical. However, recently a putative chemotaxis gene, cheV, was found to be present in S. typhimurium but not in E. coli. Sequence analysis shows that the CheV protein shares sequence similarity to both …
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Interactions between salmonella typhimurium and human gut bacteria
Salmonella enterica subsp. enterica serovar Typhimurium is an important enteropathogen that causes human morbidity and mortality worldwide. It is essential to study the interaction between Salmonella and the gut bacteria to elucidate the elements that influence the ability of the pathogen to …
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A Multifaceted Approach to Study Salmonella Typhimurium Pathogenesis
… vivo expression technology) system to select S. typhimurium genes that are specifically induced in the host during infection. This unique IVET selection was done in hopes of finding genes specifically induced in the aorta of BALB/c mice. In this selection, several genes important for the …
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A Characterization of Aspartyl Peptidases in Salmonella Typhimurium
… previously characterized from Salmonella typhimurium are capable of hydrolyzing aspartyl peptides. Peptidase E, an aspartyl specific dipeptidase, was the first member of a new family of peptide hydrolases that now includes peptidases from other proteobacteria and from two eukaryotes. It is …
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Genetic dissection of proline transport by Salmonella typhimurium
… transport. Proline transport by Salmonella typhimurium is a good model system for studying the molecular mechanism of ion-driven transport systems. The putP gene encodes proline permease, a sodium/proline symport system. In order to identify the active site of proline permease, we isolated a …
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The role of wzz genes in Salmonella typhimurium virulence.
… mechanism. While O antigen is essential for S. typhimurium virulence, the significance of length regulation by Wzz is not known. This study investigates the pathogenic relevance of the wzz genes in S. typhimurium. In addition to the previously recognised wzz gene (WZZ[subscript]ST), a second …
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Genomic diversity and genomic typing of Salmonella enterica serovar Typhimurium
Salmonella enterica serovar Typhimurium (S. Typhimurium) is one of the most frequently reported serovars in Australia. In the first study of this thesis, 21 S. Typhimurium genomes from Salmonella reference collection A (SARA) were sequenced. Together with 47 publicly available S. Typhimurium …
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Charakterisierung eines Typ III-Sekretionssystems für Virulenzproteine aus Salmonella typhimurium
… der äußeren Membran verantwortlich ist. Aus S. typhimurium konnten die als Nadel-Komplexe bezeichneten makromolekularen Strukturen, die den gesamten Sekretionsapparat darstellen, isoliert aber nicht eindeutig identifiziert werden. Da in einer SPI1-Mutante, die einen Defekt im Typ …
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Further characterisation of the envelope stress responses of Salmonella Typhimurium
… of the Cpx regulated transcriptome in S. Typhimurium, identifying 116 genes as novel members of the S. Typhimurium Cpx regulon. Transcriptomic analyses, EMSAs and mutant screens further establish CpxAR as a major contributor to S. Typhimurium virulence through regulation of SPI-1, and as a …
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Interaction of Salmonella typhimurium and Listeria monocytogenes with the murine host
… barrier. Many of these pathogens, eg Salmonella typhimurium and Shigella flexneri, use M cells, found only within the follicle associated epithelium (FAE) that overlies Peyer’s patches and other lymphoid follicles, to enter the host. This study is primarily an investigation into the interaction …
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