Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1109 for “"Type-I"”.
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… adaptive immunity and tolerance. Recently, type I cDCs (cDC1s) have been delineated as a distinct cDC subset, uniquely responsible for coordinating T cell-mediated immunity against pathogens and tumors. Although the importance of cDC1s is now well established, the mechanisms that regulate …
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Type I collagen proteostasis
… mechanisms of proteostasis for collagen type-1, the most abundant collagen in the human body. First, I explore the folding and assembly of the critically important C-terminal, globular propeptide domains of collagen-I. My data demonstrate the importance of a single amino acid in the …
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Molecular therapy for mucopolysaccharidosis Type I
Mucopolysaccharidosis type I (MPS I) is caused by deficiency of the lysosomal hydrolase alpha-L-iduronidase (IDUA). IDUA is a required component of the step-wise degradative pathway responsible for the catabolism of the glycosaminoglycans (GAGs) heparan sulfate and dermatan sulfate. As a result, …
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The type I IFN of Bos taurus
The Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to rapid expansion in the number and complexity of their genes. IFNT, which is a unique Type I IFN restricted to pecoran ruminants, also has a specialized role in maternal …
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Mechanical behavior of individual type I collagen fibrils
… Experiments were conducted with reconstituted type I calfskin collagen fibrils which were isolated from buffer and after drying were adhesively attached to a microelectromechanical systems (MEMS) device. Experiments were carried out using high-resolution optical microscopy under dry conditions …
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Mechanistic Characterization of the Mitochondrial Type I DNA Topoisomerase and a Study of Genes Containing Type I DNA Topoisomerase-Related Domains
<p>The mitochondrial type I DNA topoisomerase (mt-topo I) serves an important function in the mitochondrion by relaxing mtDNA supercoils to allow for replication of the mitochondrial genome as well as for gene expression. The mt-topo I's role in essential processes, such as replication and …
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Regulation of type I interferons in murine dendritic cells
… of innate and adaptive immune responses. Type I interferons (IFNs), as important danger signals, activate cDCs through the canonical type I IFN receptor signaling. Type I IFNs are the first line of host defense against viral infection by up-regulating IFN-stimulated genes (ISGs). However, …
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Transitioning Adolescents with Type I Diabetes to Adult Care
… improves glycemic control in adolescents with type I diabetes mellitus (TIDM). The aims of the study were to examine 1) pre and post scores in diabetes knowledge, diabetes distress, and glycemic among a sample of adolescents with TIDM participating in the SMILE program, 2) relationships between …
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Structural Analysis of Reconstituted Collagen Type I - Heparin Cofibrils
… of 2 native ECM components like collagen type I and the GAG heparin, is presented here. Although the individual components comply with the adhesive, mechanical and bioinductive requirements for artificial reconstituted ECMs, their interaction and structural characterization remains an …
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The role of type I interferon in chronic lymphocytic leukemia
Type I interferon (IFN) has pleotropic and context-dependent biological effects. IFN's involvement in viral infections is well known but its precise role in cancer remains elusive. The aims of this thesis were to study the role of IFN in chronic lymphocytic leukemia (CLL), the most common adult …
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Type I diabetes and insulin omission : an in-depth look
… been found to be a common behavior in those with type I diabetes, it has been primarily studied within the context of disordered eating behavior. Previous research supports medical providers and patients lack of comfort in discussing insulin omission. This study was designed to answer two …
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Le masquage visuel rétroactif chez les diabétiques de type I
… étude était de vérifier l'impact du diabète de type I sur l'intervalle de temps nécessaire a la perception d'un objet. A cette fin, nous avons utilise un modèle de masquage visuel rétroactif appelé le "Lagged Accrual Model" (Muise, LeBlanc, Lavoie, & Arsenault, 1991) pour identifier quel stade …
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Role of type I interferon in pulmonary inflammation and fibrosis
… Clinical studies have revealed elevated type I interferon (IFN-I) pathway activity in autoimmune patients with ILD compared to those without pulmonary involvement, with IFN-I levels positively correlating with disease severity, suggesting a potential pathogenic role in lung disease …
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Identification, state estimation, and adaptive control of type i diabetic patients
… STATE ESTIMATION, AND ADAPTIVE CONTROL OF TYPE I DIABETIC PATIENTS</b> </p> <p>by</p> <p> <b>ALI MOHAMAD HARIRI</b> </p> <p> <b>May 2012</b> </p> <p> <b>Advisor:</b> Dr. Le Yi Wang</p> <p> <b>Major:</b> Electrical Engineering</p> <p> <b>Degree:</b> Doctor of Philosophy</p> <p> During the …
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Loss of synchrony in an inhibitory network of type-I oscillators
… increase in inhibitory coupling in networks of type-I Morris-Lecar model oscillators, which is characterized by a period-doubling cascade and leads to mode-locked states with alternation in the firing order of the two cells, as reported recently by Maran and Canavier (2007) for a network of …
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Study of Type-I and Type-Ii Strained Quantum -Well Lasers
Semiconductor lasers with three types of quantum wells (QWs) (type-I, staggered type-II, and broken-gap type-II QWs) are studied. For a type-I QW structure, the 1.55-pm InGaAsP and InGaAlAs QW lasers are investigated both in the steady-state and high-speed modulation schemes. We show excellent …
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Nonreciprocal and Exotic Radiative Transfer in Type-I Magnetic Weyl Semimetals
… dissertation, we explore thermal radiation from type-I magnetic Weyl semimetals in planar configurations in the far- and near-fields. First, we demonstrate that a planar interface between air and a Weyl semimetal can intrinsically violate Kirchhoff’s law of radiation, and that nonreciprocal …
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The Impact Of Nested Testing On Experiment-Wise Type I Error Rate
… the initial risk that must be considered is a Type I error, also known as a false positive. The Type I error rate is set by nominal alpha, assuming all underlying conditions of the statistic are met. Experiment-wise Type I error inflation occurs when multiple tests are conducted overall for a …
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Maternal Intrusive Involvement and Adolescent Functioning in Youth with Type I Diabetes
… and physical well being in adolescents with type 1 diabetes is the degree of maternal involvement. Adolescents whose mothers are actively involved in the daily management of their diabetes tend to follow their regimen more consistently and are in better glycemic control. However, intrusive …
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
The type I interferon (IFN-α/β) family is a pleiotropic set of cytokines that play a role in regulating many biological functions, including suppressing viral replication and modulating adaptive immune functions. Although IFN-α/β has been extensively studied regarding the activation of interferon …
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