Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Type three domains"”.
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Spontaneous Unfolding and Refolding of FNIII Domains Assayed by Thiol Exchange
… matrix (ECM) protein that is made up of</p><p>type I (FNI), type II (FNII), & type III (FNIII) domains. It assembles into an insoluble</p><p>supra-‐‑molecular structure: the fibrillar FN matrix. FN fibrillogenesis is a cell‐‑mediated process, which is initiated when FN binds to integrins on …
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Characterization and informed design of downregulating anti-epidermal growth factor receptor antibodies
… fused to one or more EGFR-targeted tenth type three domains of human fibronectin. Both classes of constructs induce robust receptor clustering and downregulation in the absence of signal activation. In vitro downregulation correlates well with in vivo inhibition of tumor growth in several …