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Showing 1 to 20 of 71 for “"Type III secretion system"”.

  1. A Bioinformatics Analysis of Bacterial Type-III Secretion System Genes and Proteins

    Bailey, Christopher MichaelUniversity of Birmingham2010

    Type-III secretion systems (T3SSs) are responsible for the biosynthesis of flagella, and the interaction of many animal and plant pathogens with eukaryotic cells. T3SSs consist of multiple proteins which assemble to form an apparatus capable of exporting proteins through both membranes of …

    birmingham Repository record

  2. Structural study of ExsA, the regulator of Type III Secretion System of Pseudomonas aeruginosa

    Xiao, YiVirginia Tech2013

    The Type III secretion system (T3SS) of Pseudomonas aeruginosa uses a needle-like protein apparatus to detect eukaryotic host cells and translocate effectors directly into the host cell. The effectors are also known as cytotoxins, which cause disruption of a series of signaling events in the host …

    vt Repository record

  3. Molecular Interactions of Type III Secretion System Transcriptional Regulators in Pseudomonas aeruginosa: ExsA and ExsD

    Bernhards, Robert CoryVirginia Tech2013

    … the leading causes of nosocomial infections. The type III secretion system (T3SS) aids acute P. aeruginosa infections by injecting potent cytotoxins (effectors) into host cells to suppress the host's innate immune response. Expression of all T3SS-related genes is strictly dependent upon the …

    vt Repository record

  4. Characterisation of YGT a novel Type III secretion system in Biotype 1A Yersinia enterocolitica strain YE53/03

    Redhwan, AMONottingham Trent University2015

    Biotype (BT) 1A Yersinia enterocolitica is considered a group of organisms that is harmless given the lack of classical virulence factors, characteristic of pYV bearing strains. BT 1A Y. enterocolitica strains are common in the environment and in livestock, particularly the pig, with no adaption to …

    nott-trent

  5. Cellular subversion: towards a complete repertoire of type-III secretion system effectors in enterohaemorrhagic Escherichia coli O157:H7

    Matthews, Sophie AnneUniversity of Birmingham2010

    … O157:H7 is a formidable pathogen that uses a type-III secretion system to inject bacterial ‘effector’ proteins directly into host cells. Most effectors that are encoded within the locus of enterocyte effacement (LEE) have been studied extensively. This study aimed to characterise a selection …

    birmingham Repository record

  6. Molecular mechanisms underlying regulation of type III secretion system upstream of the master regulator HrpL in Erwinia amylovora

    Lee, Jae HoonUniversity of Illinois at Urbana-Champaign2014

    … hypersensitive response and pathogenicity (hrp)-type III secretion system (T3SS). It has been previously demonstrated that HrpL, an ECF sigma factor, is the master regulator of hrp-T3SS. Recently, it is reported that expression of hrpL is under the control of sigma 54 complex, including σ54 …

    uiuc Repository record

  7. Mechanism of action of AexU, a new type III secretion system effector from an emerging human pathogen Aeromonas hydrophila

    Johanna Carolina SierraThe University of Texas Medical Branch2010

    … first reported the complete sequence of the type III secretion system (T3SS) from a diarrheal isolate SSU of A. hydrophila. We identified an effector protein (designated as AexU) of the T3SS, which exhibited ADP-ribosyltransferase (ADPRT) and GTPase-activating protein (GAP) activity. AexU was …

    utmb Repository record

  8. Histidine Folding Switch In Effector Protein Avrpto Regulates Its Transport Through The Bacterial Type Iii Secretion System, As Determined By Nmr, Fluorescence, Circular Dichroism Spectroscopies And Translocation Assays

    Seckute, JolitaCornell University2011

    Bacteria have evolved several secretion systems as direct conduits into host cell cytoplasm for bacterial effector protein trafficking to further their symbiotic or pathogenic goals, while avoiding detection and host immune responses. Gram-negative bacterium Pseudomonas syringae uses the type III …

    cornell Repository record

  9. Characterization of VIBRIO Parahaemolyticus-Induced Intestinal Inflammation in the Mouse

    Lee, Olivia2010

    … of the pathogen. V. parahaemolyticus utilizes a type III secretion system to inject effectors that disrupt signal transduction in eukaryotic hosts during infection. Herein, we describe an in vivo model of infection by V. parahaemolyticus using germfree mice. V. parahaemolyticus is recovered from …

    utswmed Repository record

  10. Tagging of the type three secretion system basal apparatus of Enterohaemorrhagic Escherichia coli 0157:H7

    Emmerson, James RobinThe University of Edinburgh2008

    … Escherichia coli (EHEC) O157:H7 possesses a type III secretion system (T3SS). The T3SS translocates effector proteins into host cells during infection and consists of a basal apparatus that spans the inner and outer membranes and a needle and filament complex. The basal apparatus is composed …

    edinburgh Repository record

  11. Characterization of Mitochondrially Targeted T3SS2 Effectors in Vibrio parahaemolyticus

    Chen, Luming2025

    … All strains of V. parahaemolyticus harbor the type III secretion system 1 (T3SS1), which is dispensable for virulence in humans. Pathogenic strains harbor an additional type III secretion system (T3SS2) that mediates host cell invasion to form a protective replicative niche and is responsible …

    utswmed Repository record

  12. Transcriptional Regulation of NLRC4 Inflammasome by IRF8

    Lee, Ein2019

    … which recognize bacterial flagellin and type III secretion system (T3SS) proteins. IRF8 was critical for host survival following infection with Salmonella Typhimurium or Burkholderia thailandensis. Furthermore, mice deficient in IRF8 were impaired in their ability to produce IL-18 and …

    tenn-hsc Repository record

  13. Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB

    Piscatelli, Heather L

    … island 1 (SPI1) encoded type III secretion system (T3SS), a needle-like complex composed of over 20 proteins that translocates effector proteins directly into the host cell cytosol. <em>Salmonella</em> possess a second type III secretion system encoded on …

    purdue-thes Repository record

  14. An analysis of selected secretion systems of Pseudomonas species

    Egan, Michael FrankUniversity College Cork2014

    Direct secretion systems which deliver molecules from one cell to another have huge significance in shaping bacterial communities or in determining the outcome of bacterial associations with eukaryotic organisms. This work examines the roles of the Type III Secretion System (T3SS) and the Type VI …

    cork Repository record

  15. Rational Development of Small Molecules Targeting Virulence of Pseudomonas aeruginosa

    Triniman, RoryUniversity of Cambridge2021

    … major factors studied in this project are the type III secretion system and swarming motility. During this project rational $\textit{in silico}$ drug discovery methods were used to identify small molecule inhibitors of ExsA, the master transcriptional regulator of the type III secretion system. …

    cambridge Repository record

  16. Dissection of Innate Immunity in Tomato and Tolerance to Bacterial Wilt in Solanaceae species

    Naumenko, Anastasia NikolayevnaVirginia Tech2013

    … by bacteria into plant cells through the type III secretion system. On the other hand, plants are equipped with repertoires of resistance proteins, which can recognize some pathogen effectors. If a pathogen carries an effector that is recognized, effector-triggered immunity (ETI) is …

    vt Repository record

  17. Characterization Of A Novel Effector From Blumeria Graminis F. Sp. Hordei That Suppress Host Cell Death

    Qi, ShanCornell University2015

    … of BEC1019 to the host cytoplasm via Xanthomonas type III secretion suppresses cultivar non-specific hypersensitive reaction (HR) induced by Xanthomonas oryzae pv. oryzicola, as well as cultivar specific HR induced by AvrPphB from Pseudomonas syringae pv. phaseolicola. BEC1019 homologs are present …

    cornell Repository record

  18. The role of citrate in plant-pathogen interactions

    Hendry, Tia LynneDepartment of Molecular and Cell Biology2016

    … and as an inducer of genes associated with the type III secretion system (T3SS) and phytotoxin production. The effect of citrate on the host is less clear, though microarray analysis of Arabidopsis thaliana has demonstrated that application of exogenous citrate leads to the differential …

    cape-town Repository record

  19. Tale of Two Hosts: Vibrio parahaemolyticus Toxicity Against Human and Shrimp

    Li, Peng2016

    … VtrB, are required for activating the virulence type III secretion system 2 (T3SS2) in response to bile salts. The VtrA/VtrC complex activates VtrB in the presence of bile salts. The crystal structure of the periplasmic domains of the VtrA/VtrC heterodimer reveals a β-barrel with a hydrophobic …

    tdl Repository record

  20. Tale of Two Hosts: Vibrio parahaemolyticus Toxicity Against Human and Shrimp

    Li, Peng2019

    … VtrB, are required for activating the virulence type III secretion system 2 (T3SS2) in response to bile salts. The VtrA/VtrC complex activates VtrB in the presence of bile salts. The crystal structure of the periplasmic domains of the VtrA/VtrC heterodimer reveals a β-barrel with a hydrophobic …

    utswmed Repository record

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