Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 307 for “"Type III"”.
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Type III Polyketide Synthases: Discovery, Characterization, and Engineering
The polyketides are a diverse group of natural products with important applications in medicine and industry. Industry, especially the pharmaceutical industry, is under pressure to deliver "greener" chemical syntheses that are less environmentally damaging and incorporate renewable resources. There …
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Functional Characterization of Four Xanthomonas euvesicatoria Type III Effectors
… virulence and avirulence functions of four Xe Type Three Secretion Effectors (T3Es): Xe-XopQ, Xe-XopX, Xe-XopN, and Xe-avrRxo1. Xe-XopQ is a Xe T3E that functions as a determinant of host specificity. Here, we further explored the virulent and avirulent functions of Xe-XopQ. We identified …
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Characterization of the Type III Effector VOPA from Vibrio Parahaemolyticus
… genome revealed the presence of a type III secretion system (TTSS) encoded within a pathogenicity island. Within this pathogenicity island a homologue of the Yersinia type III effector YopJ was found and is referred to as VopA (Vibrio outer protein A). The founding member of the …
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Structural and functional characterization of a Xanthomonas Type III effector
… important rice bacterial diseases. Xanthomonas type III effector gene avrRxo1 is conserved in diverse Xoc strains and its homologues have been identified from several other gram-negative bacteria species such as Burkholderia and Acidovorax. In this research, we studied the protein structure of …
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Optical Properties of Type III-V Semiconductor Spherical Quantum Dot Heterostructures
… heterostructures. Our emphasis will be on type III-V semiconductors. Such structures, have a great potential for increasing efficiencies, but they also possess highly degenerate and complex valence band structures. Therefore, we seek to develop a model of spherical QD band structure for …
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Localization and Function of Bacterial Type III and IV Effector Proteins
Eukaryotic cell signal transduction networks are highly dynamic and complex systems largely composed of signaling enzymes with modular protein interaction domains and subcellular localization motifs. These sophisticated regulatory mechanisms are crucial to the fidelity and efficacy of information …
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
… or RNA that is complementary to the crRNA. The type III CRISPR-Cas system is also able to synthesize a cyclic small molecule from ATP through the cyclase domain of Cas10. This molecule, termed cyclicoligoadenylate (cOA), typically contains 3, 4, or 6 cyclized AMP molecules to produce cA3, cA4, …
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Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
<p>The type III TGF-β receptor (TβRIII) is a TGF-β co-receptor that presents ligand to the type II TGF-β receptor to initiate signaling. TβRIII also undergoes ectodomain shedding to release a soluble form (sTβRIII) that can bind ligand, sequestering it away from cell surface receptors. We have …
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Substrate targeting and recognition in the flagellar type III secretion pathway
… cell membrane by a specialised flagellar type III secretion system (fT3SS) located at the base of each flagellum. These subunits are unfolded and exported into a narrow 20Å wide channel in the centre of each flagellum energised by the proton motive force (PMF) and facilitated by a …
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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems
… destroy the invader's genome. To date, six major types and multiple subtypes of CRISPR systems exist, each with their own signature genes and mechanisms of action. Type III CRISPR systems are uniquely able to destroy both the parasite's DNA and RNA. Type III loci contain Cas10 and Csm2-5, which …
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A Study Of Novel Activities Of Type Iii Sirtuins: Cobb And Pfsir2A
… cellular functions. The discovery of Sirt5's, a type III mammalian sirtuin,novel desuccinylase/demalonylase activity opened up new possibilities of cellular protein regulation. Two conserved active site residues, Tyr and Arg, are believed to be responsible for Sirt5's desuccinylase/demalonylase …
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Crystal structure of the Large Type III Glutamine Synthetase from Bacteroides Fragilis
… the GSI and GSII families. The most divergent GSIII family, however, is poorly characterized and has only recently been recognized. Structural studies, using both cryo-EM and X-ray crystallography, were undertaken on the type III GS, GlnN, from the opportunistic human pathogen, Bacteroides …
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A Bioinformatics Analysis of Bacterial Type-III Secretion System Genes and Proteins
Type-III secretion systems (T3SSs) are responsible for the biosynthesis of flagella, and the interaction of many animal and plant pathogens with eukaryotic cells. T3SSs consist of multiple proteins which assemble to form an apparatus capable of exporting proteins through both membranes of …
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Roles of non-Cas nucleases in Type III-A CRISPR-Cas immunity
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Polyacrylamide gradient gel electrophoresis for the diagnosis of dysbetalipoproteinaemia (Type III hyperlipidaemia)
… available, especially testing for the E2/E2 genotype which is the commonest underlying genotype in dysbetalipoproteinaemia. Testing for the rarer autosomal mutations of ApoE is restricted to a small number of centres only. In this study I will review dysbetalipoproteinaemia briefly and then …
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Three-dimensional structure of a type III glutamine synthetase by single particle reconstruction
… the first structural investigation of any type III glutamine synthetase (GS). The GS, GlnA, from the medically important opportunistic human pathogen Bacteroides fragilis was studied with a view to better understanding its structure/functioning in relation to the extensively characterised …
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Uncovering New Mechanisms of Type III CRISPR-Cas System Inhibition and Effector Function
… (Cas) proteins. While there are seven distinct types of CRISPR-Cas systems identified thus far, we focus on specifically the type III CRISPR system which contains a multi-protein effector complex that functions together with its crRNA in target binding and cleavage. During type III CRISPR-Cas …
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A Systems Biology Approach to Study Type III and Type IV Bacterial Effector Properties
The interaction between Type III and Type IV bacterial effector proteins and host signal transduction enzymes is a critical interface that, in many cases, determines the outcome of infectious disease. While many pathogenic strategies, such as evasion of phagolysosomal fusion, have been identified …
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Structural and Functional Characterization of SPOA Domains in Salmonella Typhimurium Type III Secretion Systems
… approach anti-infective therapeutic design. Type III secretion systems (T3SS) are employed by some gram-negative human pathogens to manipulate the host environment. One T3SS subtype, known as the "injectisome," delivers virulence factors directly into host cells. The other T3SS subtype …
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Role of the Type III TGF-beta Receptor Cytoplasmic Domain in Breast Cancer Progression
… of cancers. In particular, the expression of the type III TGF-β receptor (TβRIII) is decreased with cancer grade and clinical progression in prostate, lung, ovarian, and pancreatic cancers. In an effort to enhance our understanding of the biology of TGF-β on carcinogenesis, this …
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