Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Type I interferon response"”.
-
The role of the type-I interferon response in the aggregation of tau protein
… prominent neuroinflammation. The innate immune response, the first line of defence against foreign pathogens, is emerging as a major contributor to the development of neurodegenerative disease. IFN-Is are soluble cytokines produced in the innate immune response which induce an antiviral …
-
THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… multi-cellular organisms mount an immune response that recognizes, sequesters and eradicates invading infectious agents. Critical to this safeguard is the receptor-mediated detection of pathogens. Pathogen recognition then initiates a variety of signaling cascades that lead to the …
-
A single-cell perspective on infection
… characterized by high expression of the Type I Interferon response after infection. Upon further investigation we found that this heterogeneity in the host Type I Interferon response was the result of heterogeneity in the population of infecting bacteria, namely in the extent of …
-
Mechanisms of Macrophage Detection and Control of Mycobacterium tuberculosis Infection
… is characterized by the production of a robust type I interferon response dependent on the activation of a cytosolic surveillance pathway by the recognition of M. tuberculosis DNA in the cytosol. The DNA sensor recognizing M. tuberculosis DNA and initiating activation of the cytosolic …
-
Human Cellular Genetics of Innate Immunity
The type I interferon response is a key part of the innate immune system, responding to infection and inducing an antiviral intracellular state. While there is known to be variability in this signalling pathway between individuals, alongside cell-to-cell heterogeneity in a genetically identical …
-
Human Neural Stem Cell-Derived Neuron/Astrocyte Co-Cultures as a Model System to Study Emerging Encephalitic Viruses
… signaling defects that may impact cellular responses to infection. This study describes the establishment of a human neural stem cell derived neuron/astrocyte co-cultures system as a model to study encephalitic virus infection. This system provides a more physiologically relevant model that …
-
Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… to counter virus infection is production of type I interferon (IFN), an innate immune response that generates antiviral state to prevent virus replication and spread by expressing several IFN-stimulated genes. Type I interferon response depends on a set of germ-line encoded receptors called …
-
Combinatorial lipid-like materials for intracellular delivery of small RNAs that activate innate antiviral immune responses and adjuvant vaccines
… same siRNA can also activate an innate immune response. Recognition of RNA by specialized immune cells occurs through pattern recognition receptors, which have evolved to respond to RNA viruses, such as the Toll-like receptors (TLR) 7 and 8 located in the endosome of dendritic cells. Tailoring …
-
Modulation of innate immune responses in nasopharyngeal epithelial cells by the Epstein-Barr virus (EBV)-encoded latent membrane proteins LMP2A and LMP2B
… to counteract the effects of this immune response and to prevent recognition of viral antigens by the adaptive immune response. Here novel functions for LMP2A and LMP2B are described with respect to modulation of innate immunity, findings which have implications for the role of these …
-
Mechanisms Controlling Virulence Thresholds of Mixed Viral Populations and Identification of Novel Host Barriers to Poliovirus Neuropathogenesis
… in peripheral axons is limited and the type I interferon response limits viral replication in peripheral tissues, protecting against disease. Significantly, we discovered that retrograde axonal transport of poliovirus in the sciatic nerve was inefficient and only 20% of viral pool …
-
Restriction of Retrotransposition and Retroviral Infection by RNase L and APOBEC3G
… major restriction pathways activated during the type I interferon response to viral infections. In this thesis I primarily explored its non-canonical functions beyond blocking viruses through degrading viral and cellular single-stranded RNA. Using genetically-engineered retrotransposon …
-
Influenza A Virus PB1-F2 Protein: its Role in Pathogenesis
… nasal shedding, lung viral load, immunophenotypes, and lung pathology in pigs. On the other hand, in turkeys, deletion of PB1-F2 resulted in early induction of clinical disease and effective transmission among the turkey poults. Interestingly, the virulence associated 66S mutation in PB1-F2 …
-
Deciphering the molecular basis of the global emergence of non-tuberculous Mycobacteria as important human respiratory pathogens
… that the bacteria manipulate the host immune response to their advantage; however, the intracellular trafficking and survival strategies are poorly understood.<br/><br/>To address this, we have developed an image-based, single cell assay using a fluorescence dilution (FD) system to measure …
-
Cooperative Tumor Suppression by ARF and p53
… cells against numerous biological stresses. In response to oncogenic signals, increased ARF expression leads to the activation of p53, which in turn leads to the cessation of cell division or induction of an apoptotic response. Interestingly, p53 coordinates repression of Arf transcription, …
-
Heligmosomoides polygyrus-induced serum factors limit respiratory syncytial virus titres: a potential role for CCL8
… chronic infections within mice. The robust host Type 2 immune response to H. polygyrus infection can lead to a subdual of excess inflammation caused by a Type 1 immune response. Respiratory syncytial virus (RSV) is one of the most common viral respiratory infections among infants, young children, …
-
Development of novel RNA- and protein-based cancer therapeutics by either silencing of potential oncogenes or active restoration of a tumor suppressor gene
… and by their ability to elicit cancer phenotypes in experimental models. Typical treatments for cancer include surgery, radiation therapy and chemotherapy. However, chemotherapy also kills normal cells because tumor cells are not specifically targeted, resulting in significant side effects. …
-
ISG15 conjugation : cellular targets and the lysine selectivity of HERC5
… protein that functions in the innate immune response to pathogens. While human ISG15 is a multifunctional protein, its canonical function is that of an intracellular ubiquitin-like protein modifier. Like ISG15, the human E1 (UBE1L), E2 (UBE2L6) and E3 (HERC5) enzymes for ISG15 are all induced …