Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Type I Interferon (IFN)"”.
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The Biology of Dendritic Cells in the Context of Autoimmunity
… people worldwide. An increased expression of type I interferon (IFN) regulated genes is a hallmark of SLE, but the precise etiology of SLE initiation and flares is poorly understood. Because plasmacytoid dendritic cells (pDCs) are the primary type I IFN producers, their role in SLE has long …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… necrosis factor alpha (TNFα). I hypothesize that type I interferon (IFN) stimulation in cancer cells and in immune cells leads to the production of TNFα, which can then synergize with SMCs to kill cancer cells. The combined treatment of SMC and IFNα induces tumour regression in mice, and this …
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Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
… which includes the production of anti-viral interferons. TLRs 3, 4, and 7/8 and the RLR, RIG-I, are the primary PRRs involved in the recognition of RNA viruses and they signal through the adaptors TRIF (TLR3, 4), MyD88 (TLR4, 7/8, 9), and MAVS (RIG-I). The innate response serves to limit …
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Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells
… to infectious agents. Using the expression of type I interferon (IFN) as a benchmark of antiviral responses, our results indicated that the type I IFN were robustly induced in C3Hl0Tl/2 cells, but not in ESCs, when they were exposed to polyinosinic:polycytidylic acid (poly(I:C), a dsRNA viral …
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Characterization of cholesterol 25-hydroxylase expression in human macrophages
… an increasingly appreciated connection between type I interferon (IFN-I) and lipid metabolism. Moreover, the details of this connection appear to differ in mouse and human cells. Nevertheless, the molecular basis for the induction of CH25H in humans is not known. Objective Elucidation of …
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Subversion of innate antiviral immunity by SARS-CoV-2: An example from the study of nonstructural protein 16.
… that the NSP16 mutant is more sensitive to type I interferon (IFN-I) in vitro. Furthermore, silencing IFIT1 or IFIT3, IFN-stimulated genes that sense a lack of 2’-O methylation, partially restores fitness to the NSP16 mutant. Conversely, overexpressing IFIT1 either alone or in combination …
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The role of type I interferon in chronic lymphocytic leukemia
Type I interferon (IFN) has pleotropic and context-dependent biological effects. IFN's involvement in viral infections is well known but its precise role in cancer remains elusive. The aims of this thesis were to study the role of IFN in chronic lymphocytic leukemia (CLL), the most common adult …
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Regulation of Effector and Memory Development of Human CD4+ T Cells by Interleukin 12 and Type I Interferon
… the innate cytokines interleukin 12 (IL-12) and type I interferon (IFN-alpha/beta) are produced in response to intracellular bacterial and viral infections. While the effects of IL-12 on CD4+ T cell differentiation are relatively well-understood, the role of IFN-alpha/beta, despite extensive …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… or tumor progression following BCG treatment. Type I interferon (IFN-I) has potent anti-tumor effects against urothelial carcinoma (UC) and may be an alternative treatment option for patients who do not respond to BCG standard of care. However, the mechanisms that mediate the IFN-I-stimulated …
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
… Previous studies have shown activation of the Type I interferon (IFN) response prior to VEEV infection led to viral inhibition. Interferon stimulated genes (ISGs) are produced in response to VEEV infection and can be regulated through multiple arms of the Type I IFN response. Numerous studies …
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The Impact Of Interferon Regulatory Factor 3 On The Immune Response To Herpes Simplex Virus Type I Infection
The type I interferon: IFN) cascade is critical in control of herpes simplex virus type I: HSV-1) infection and relies on specific recognition molecules to rapidly signal viral infection via interferon regulatory factor-3: IRF-3) -dependent pathways. The absence of these recognition molecules or …
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Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… the innate cytokines Interleukin-12 (IL-12) and type I interferon (IFN-a/b) are induced to high levels by intracellular bacterial and viral infections and have been shown to promote adaptive T lymphocyte responses to infection. While the role for IL-12 on the development of T lymphocyte effector …
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
The type I interferon (IFN-α/β) family is a pleiotropic set of cytokines that play a role in regulating many biological functions, including suppressing viral replication and modulating adaptive immune functions. Although IFN-α/β has been extensively studied regarding the activation of interferon …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
… (PRRs). These PRRs trigger the production of type-I interferon (IFN-I), which is essential to establish antiviral innate immunity, allowing for the clearance of the offending organism. This process is tightly controlled by post-translational modifications (PTMs), like unanchored (or free) …
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The Role of LIFR Signaling in Innate Immunity
… we find LIFR prevents abnormal activation of type I interferon (IFN-I) signaling in BM monocytes, which is accompanied by an increased activation phenotype and altered transcriptional state in homeostasis. Additionally, we observed that LIFR is required to limit anomalous BM HSC proliferation. …
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The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
… leads to the upregulation of a maturation phenotype and the production of type I interferon (IFN) as well as the induction of a strongly polarised TH1, IFN-γ dominated allogeneic T cell response. In contrast, monocyte-derived Langerhans cells (MDLC), display only partial maturation phenotype and …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
… amounts of pro-inflammatory cytokines, including IFN-alpha. Furthermore, ICs might activate platelets and thus be involved in the development of cardiovascular diseases which is increased in SLE patients. In this thesis I have investigated the immunopathogenesis of SLE with an emphasis on ICs, …
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Identification and Characterisation of Human Cytomegalovirus-Mediated Degradation of Helicase-Like Transcription Factor
… early protein, however had a possible role in type I interferon (IFN) induction regulation in later stages of HCMV lytic progression. As the key host protein to be rescued by UL145 deletion, depletion of HLTF was found to transiently impair IFNβ transcription and HCMV infection. I hypothesise …
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Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
… versus bystander cells exposed to paracrine type-I interferon (IFN). Infected cells downregulated Clec2d nascent transcripts, mainly due to absence of RNAPII recruitment to the Clec2d promoter. Moreover, a cell-autonomous role for the MCMV ie3 gene product was also discovered, whereby ectopic …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… to counter virus infection is production of type I interferon (IFN), an innate immune response that generates antiviral state to prevent virus replication and spread by expressing several IFN-stimulated genes. Type I interferon response depends on a set of germ-line encoded receptors called …
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