Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"Type 2 diabetes mellitus (T2DM)"”.
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Physical activity and depression among overweight women with Type 2 Diabetes Mellitus
… (PA) and depression in overweight women with Type 2 Diabetes Mellitus (T2DM). To do this, I conducted three linked studies. In Study 1, I examined the relationship between PA and depression in overweight women with T2DM. In Study 2, I explored the PA barriers and facilitators for overweight …
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Modelling knowledge, attitudes, self-management, and quality of life in type 2 diabetes mellitus
… was to investigate the relationship between diabetes knowledge, attitudes, self-management, and quality of life (QoL) of people with Type 2 Diabetes Mellitus (T2DM). The main hypothesis was there would be significant relationships between diabetes knowledge, attitudes, self-management, and …
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HORMONE AND FLAVONOL REGULATION OF MAMMALIAN METABOLIC SIGNALING PATHWAYS
… associated with debilitating diseases including Type 2 Diabetes Mellitus (T2DM). Both obesity and T2DM are linked to altered peptide hormone signaling, including insensitivity to insulin and leptin. Research in this dissertation investigated how gender, weight loss, and diet components affected …
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Influence of Vitamin D Receptor Gene Polymorphisms on Changes in Insulin Sensitivity with Aerobic Exercise Training
… training in men and women at increased risk for type 2 diabetes mellitus (T2DM). Subjects were genotyped and underwent oral glucose tolerance tests before and after six months of training. Due to mis-genotyping of the BsmI polymorphism, results for that variant were not reported. There were no …
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The effects of resistance training on individuals with clusters of metabolic risk factors: focus on functional capacities, clinical outcomes and quality of life
… associated with the metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) has increased considerably over the past two decades. Lifestyle factors including physical inactivity are major components in the development of HiMF. Middle-aged individuals with HiMF …
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
Obesity-related comorbidities, including type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) have become a major public health concerns. These complications primarily arise in response to cellular changes in white adipose tissue (WAT). In particular, when a majority of fat …
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Akt2 Redox-regulation in Breast Cancer and Diabetes
… homeostasis with Akt2 knockout mice displaying a type 2 diabetes mellitus (T2DM) like phenotype. Humans with mutation in the kinase domain of Akt2 exhibit severe insulin resistance. Additionally, increases in overall Akt expression have been linked to increased risk of breast cancer metastasis and …
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Developing C. elegans as a model to study Type 2 Diabetes Mellitus
… study heterogeneous metabolic syndromes such as Type 2 Diabetes Mellitus (T2DM) as C. elegans can be used to delineate molecular pathways that are at the core of its problems. A growing number of populations worldwide are faced with chronic T2DM, which also manifests several complications, such …
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Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models
Type 2 Diabetes Mellitus (T2DM), a metabolic disorder denoted by elevated blood glucose levels and insufficient insulin action, is growing in prevalence worldwide . Barriers to improving disease outcome resolve primarily around identifying and intervening during the preliminary stages of insulin …
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How a structured exercise programme involving cardio and resistance exercise affects type 2 diabetes mellitus volunteers
Background T2DM is a metabolic disorder that is rapidly increasing in prevalence, it has become a 21st century epidemic and addressing this is one of the greatest global health challenges of our time. In the UK £10.3 billion or 10% of the NHS budget was spent on diabetes mellitus. It is essential …
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Investigations into the Effects of Turmeric, Cinnamon and Green Tea on Glycaemic Control and Liver Enzymes
… and obesity, leading to an epidemic increase in type 2 diabetes mellitus (T2DM). Overweight, cardiovascular disease and diabetes are closely linked, and cardio-vascular disease is the most important cause of morbidity and mortality among patients with T2DM. Identifying food that can reduce blood …
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The Epidemiology of Auditory Dysfunction in Type 2 Diabetic Adults in Africa: 4 A Systematic Review and Meta-analysis
Background: There is a growing rate of diabetes related hearing loss (HL) worldwide. However, in under-developed countries, HL is still under-recognised as a complication of type 2 diabetes mellitus (T2DM). Although Africa presents a significant rise in T2DM every year, it is met with limited …
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Patient Knowledge, Perceived Self-Efficacy, and Self-Management Among Patients with Type II Diabetes Mellitus
<p>In the United States (U.S.), Type 2 Diabetes Mellitus (T2DM) has reached epidemic portions with a prevalence of approximately 29.1 million people and is the seventh-leading cause of death (Centers for Disease Control and Prevention [CDC], 2014; Healthy People 2020, n.d.). The U.S. spends an …
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Investigating the effectiveness of New Zealand Blackcurrant extract to modulate postprandial glycaemia in overweight/obese individuals
Obesity and type 2 diabetes mellitus (T2DM) has now reached epidemic proportions, and therefore strategies to prevent and treat these conditions are required. Long-term adherence to current strategies that primarily revolve around increasing energy expenditure or reducing caloric intake is poor, …
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The Differential Effects of Progressive Resistance Exercise Training on Measures of Sarcopenia and Acute Nutrient Response in Older Adults with and without Type 2 Diabetes Mellitus
… sarcopenia is accelerated in older adults with Type 2 Diabetes Mellitus (T2DM), and that this acceleration is compounded by increasing disease severity. However, the reasons underlying this acceleration remain unknown. In a similar vein, the effect of T2DM on sarcopenia treatment outcomes, in …
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Development Of An Educational Program On Prevention Of Hypoglycemic Events Among Elderly Veterans With Type 2 Diabetes
… hypoglycemic events in elderly veterans with type 2 diabetes mellitus (T2DM) enrolled in the Veterans Healthcare Administration system. US elderly persons are especially affected by T2DM and at great risk for complications. Until recently, tight glycemic control has been advocated to avoid …
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The Role of Leucine and Its Metabolite (KIC) in Insulin Signalling and Glucose Transport in L6 Myotubes
… in the development of insulin resistance and type 2 diabetes mellitus (T2DM). This study examines the dose-dependent effect of leucine in the presence or absence of other amino acids on glucose transport in L6 rat myotubes. Here we report that leucine significantly suppresses …
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Social Comparison Theory in the Context of Chronic Illness: Predictors and Consequences of Target Selection among Individuals with Type 2 Diabetes
… social comparison process among patients with Type 2 Diabetes Mellitus (T2DM) - a condition that is a growing public health concern for which psychosocial interventions can be beneficial. Patient participants used a web-mediated program to self-report individual difference characteristics prior …
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Implementation of diabetes tracking applications into the chronic care model in the Program of All-Inclusive Care for the Elderly (PACE) : a quality improvement effort
Background: People with type 2 diabetes are at a higher risk of debilitating consequences such as impaired vision, nephropathy, and decreased quality in life, resulting in premature death. The cost of diabetes care is also at least 3.2 times greater than the average per capita health care …
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The Role of Digital Technology in the Self- Management of Type 2 Diabetes Among the Aging Population, in the United Kingdom. A Systematic Literature Review.
Diabetes is a growing public health concern globally, with Type 2 Diabetes Mellitus (T2DM) being the most prevalent form. The aging population is at an increased risk of developing T2DM due to physiological changes and lifestyle factors. Effective self-management of diabetes is crucial for …
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