Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 937 for “"Type 2 Diabetes"”.
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Type 2 Diabetes Mellitus Growing Evidences
An overview of type 2 diabetes in children and adolescents. The definition and the worldwide development of type 2 diabetes in different countries will be first discussed. After that, I will focus on the pathomechanism and the risk factors that distribute to this significant growth in recent …
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The molecular genetics of Type 2 diabetes
Type 2 diabetes has a substantial genetic component. The aim of this dissertation was to investigate the molecular basis of Type 2 diabetes with particular emphasis on the role of the glucokinase gene. Other work studied specific mutations in the tRNA<sup>Leu(UUR)</sup> gene of mitochondrial DNA …
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Treating type 2 diabetes through insulin resistance
Type 2 diabetes is an insidious disorder, with micro and/or macrovascular and nervous damage occurring in many patients before diagnosis. This damage is caused by hyperglycaemia and the diverse effects of insulin resistance. Obesity, in particular central obesity, is a strong pre-disposing factor …
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Genetic association between schizophrenia and type-2 diabetes
… there is a close link between schizophrenia and type-2 diabetes (T2D). Patients with schizophrenia have a high risk of T2D. In order to clarify a genetic association between these two conditions, this study was designed to investigate a genetic pathway that might be associated with both …
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Mitochondrial and chromosomal genomics in type 2 diabetes
… mechanisms of complex polygenic diseases like type 2 diabetes (T2D) is as complex as their nature. Cellular processes involved in glucose homeostasis need high and reliable energy supply. Mitochondria are the major energy producers in mammalian cells. Since majority of the mitochondrial genes …
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The primary care consultation in type 2 diabetes
Type 2 diabetes is a common condition that is associated with high rates of morbidity, mortality and healthcare costs. Multifactorial management has been shown to be effective in preventing complications and inducing remission or cure of the disease. Despite this, the rate of new cases and the …
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Type 2 Diabetes And Insomnia: Impact On Metabolic Control
<p>Diabetes is one of the most serious health challenges in the United States, affecting nearly 21 million Americans. The goal of diabetes management is to maintain the blood glucose close to normal to prevent diabetic complications and therefore extending life expectancy and improving quality of …
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Therapeutic Approaches to Insulin Resistance and Type 2 Diabetes
Type 2 diabetes is a chronic metabolic disorder primarily caused by a systemic insulin resistant state to which obesity is a major contributor. Increasing visceral adipose tissue augments adipokine secretion provoking an enduring low-grade inflammatory response that negatively impacts on the …
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Mechanisms of defective insulin secretion in type 2 diabetes
… the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. This thesis uses a combination of gene network analysis and cell-physiological techniques to explore the genetic …
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Exercise capacity with special reference to type 2 diabetes
… (NGT), impaired glucose tolerance (IGT) and with type 2 diabetes (T2D) was the influence of insulin sensitivity on exercise capacity studied (Study III). Exercise testing and exercise training in individuals with T2D was examined in a group of middle aged women with T2D in study IV and V. The …
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A multi-ancestry genetic analysis of type 2 diabetes
Diabetes affects more than 589 million people worldwide. It is one of the leading causes of death and costs over $1 trillion in annual global health expenditures. Type 2 diabetes (T2D) comprises ~90% of diabetes cases, is characterised by pancreatic islet beta cell dysfunction and reduced insulin …
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Screening strategies for adults with type 2 diabetes mellitus
… trials to address whether screening for type 2 diabetes mellitus (T2DM) improves health outcomes. This systematic review sought to cast a wider net and synthesise evidence from non-randomised intervention studies to assess the effectiveness of T2DM screening in adults for reducing …
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Exercise and glycemic control in individuals with type 2 diabetes
Type 2 diabetes (T2D) and the associated impaired glycemic control greatly increases the risk of cardiovascular disease mortality. PURPOSE: It is unknown if or for how long a single bout of exercise will reduce post-prandial glucose levels in individuals with T2D. METHODS: We recruited 9 …
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Systematic opportunistic screening for type 2 diabetes in general practice
… people in New Zealand may have undiagnosed diabetes. This study aims to develop ‘systematic opportunistic screening’ for diabetes, testing people attending a general practitioner (GP) for some other reason, and to trial this process with Auckland GPs. The literature on how to change doctor …
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Proteomic Signatures of Type 2 Diabetes and Related Metabolic Traits
… via proteome to a variety of metabolic phenotypes, providing unique opportunities to better understand disease mechanisms and identify molecular signatures that can help to predict, screen for and diagnose different diseases using agnostic discovery approaches. The proteome is at the centre …
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GENETIC AND BIOCHEMICAL ANALYSIS OF TYPE 2 DIABETES AND DIABETIC COMPLICATIONS
Over 29 million Americans (9.3%) are affected by type 2 diabetes (T2D). T2D is characterized by the body not producing enough insulin and not responding to the insulin that it does produce resulting in high blood glucose. Common complications associated with T2D include cardiovascular disease …
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GENETIC VARIATION OF TYPE 2 DIABETES AND NEPHROPATHY ACROSS ETHNIC GROUPS
Type 2 diabetes mellitus is a complex disease characterized by insufficient insulin secretion and action in the body. Diabetes and associated comorbidities represent significant health burdens throughout the world due to resultant direct and indirect complications. In the United States, the …
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