Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Type 2 DM"”.
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The Effect of Weight Reduction on Chronic Inflammatory Molecules and Insulin Resistance in type 2 DM
Type 2 Diabetes mellitus(DM) is characterized by insulin resistance. Recently, defects in the insulin-signaling cascade have been implicated in the pathogenesis of insulin resistance. Also obesity is a metabolic disease and insulin resistance is a pathogenesis of obesity. So obesity is correlated …
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Hyperinsulinemia and Hyperglycemia Contribute to Diabetic Complications Through Cytokine Resistance and Altered Macrophage Function
… to the association between two hallmarks of type 2 DM, hyperinsulinemia and hyperglycemia, and the conditions pertinent to the development of diabetes-accelerated atherosclerosis. Chapters 2 through 4 establish that (1) the rapamycin pathway plays an integral role in serine phosphorylation …
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Retrospective analysis of pregnancies at the Grootte Schuur Hospital : a comparison of pregnancy outcomes in pre-gestational and gestational diabetes
… (i) pregnancy outcomes in pre-gesational types 1 and 2 diabetes (DM) with particular emphasis on the modality of therapy for pregnant women with type 2 DM, (ii) pregnancy outcomes in subjects with gestational diabetes (GDM) and the effect of stratification by fasting plasma glucose (FPG) …
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The Effects of Resistant Starch Intake in African-American Americans at Increased Risk for Type 2 Diabetes
… group with disproportionately elevated rates of type 2 Diabetes Mellitus (DM). Resistant starch is a promising food ingredient that has the potential to reduce the risk factors involved in the development of type 2 DM. To date, there is a dearth of published research studies on the effect of …
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Intergenerational effects of early life programming: the role of glucocorticoids and maternal obesity
Hypertension and type two diabetes mellitus (Type 2 DM) are serious chronic illnesses that impact on the lives of millions of people around the world. Various epidemiological studies have shown a relationship between early life events such as intrauterine growth retardation (IUGR) resulting in low …
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Exercise Rehabilitation Efficacy and Optimal Exercise Training Prescriptions for Improved Health Outcomes in People with Type 2 Diabetes
… health outcomes for people with diabetes (DM). Exercise is an accepted part of the diabetes management regime to help prevent or slow the progression of the disease. A combined aerobic and resistance training protocol is the recommended exercise regime for people with DM, but the question …
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Stem cell-based regenerative pharmacology for the treatment of diabetes mellitus
… organ replacement or repair. Diabetes mellitus (DM) is a group of chronic metabolic disorders characterized by high blood glucose levels. Type 1 DM (T1DM) is a lack of insulin production caused by autoimmune destruction of the beta-cells, while Type 2 DM (T2DM) is insulin resistance in peripheral …
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Bone health and cardiovascular risk in hypopituitary patients on complete hormone replacement, including GH
… cardiovascular diseases and diabetes mellitus (DM) in hypopituitary patients and the prevalence of cardiovascular morbidity and risk factors in adults with childhood onset (CO) craniopharyngioma (CP) are unknown. We have shown that the life-long incidence of non-fatal stroke was tripled in GHD …
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Comparison of two diabetes mellitus exercise programmes with respect to exercise adherence and physiological and psychological effects
The prevalence of type 2 diabetes mellitus (DM) has increased 5-fold over the last 20 years worldwide. Contributed to by an obesity epidemic and sedentary lifestyles, DM is costing the UK Government £5.2 billion a year and this amount is rising gradually. Exercise is a major cornerstone for …
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Adherence to treatment by patients with type 2 diabetes mellitus at Monze Mission Hospital,Monze,Zambia
… study was to assess adherence to treatment by type 2 Diabetes mellitus patients aged 20 years and above at Monze Mission Hospital in Monze district. It sought to answer the research questions: (1) What is the level of adherence to treatment by patients with type 2 Diabetes mellitus receiving …
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Maternal diabetes during pregnancy – obstetrical considerations and long term effects
Maternal diabetes mellitus (DM) during pregnancy has detrimental health impacts on both the mother and fetus, and include increased risks of cardiac malformations, cesarean section (CS), and asphyxia. The aim of the thesis was to investigate short and long term cardiac effects after fetal exposure …
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The regulation of ceramide content and insulin resistance in skeletal muscle
… obesity and is a trait of the beginning stage of type 2 diabetes mellitus (DM). It is highly likely that the high plasma fatty acid levels provoke the condition in the obese and insulin resistant state of type 2 DM. Hence, the purpose of this study was to determine if a high concentration of …
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Data mining and mathematical modelling on diabetes
… metabolic disease known as diabetes mellitus (DM), which is characterized by significant glucose variation due to lack of insulin secretion, lack of insulin action, or both. DM can be broadly classified into two types: type 1 diabetes mellitus (T1DM) - which is caused mainly due to lack of …
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Functional, Structural and Molecular Alterations in the Heart and Kidney During Diabetes Mellitus
Background: Diabetes mellitus (DM) is a major metabolic disorder leading to severe long term complications including cardiomyopathy, nephropathy, retinopathy and neuropathy that are common in type 1 DM (T1DM) and type 2 DM (T2DM). Epidemiological studies have demonstrated a role of hyperglycaemia …
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Development, evaluation, and In-vitro assessment of artificial intelligence antidiabetic predictive models from α-glucosidase inhibitors
… rise in the prevalence of diabetes mellitus (DM) poses a significant health challenge, necessitating effective therapeutic interventions. Type 2 DM (T2DM) remains the most prevalent form of diabetes, accounting for over 90% of cases. Intestinal α-glucosidase enzymes, located at the small …