Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1391 for “"Type 2"”.
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Type-2 Fuzzy Alpha-cuts
Systems that utilise type-2 fuzzy sets to handle uncertainty have not been implemented in real world applications unlike the astonishing number of applications involving standard fuzzy sets. The main reason behind this is the complex mathematical nature of type-2 fuzzy sets which is the source of …
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Type 2 Diabetes Mellitus Growing Evidences
An overview of type 2 diabetes in children and adolescents. The definition and the worldwide development of type 2 diabetes in different countries will be first discussed. After that, I will focus on the pathomechanism and the risk factors that distribute to this significant growth in recent …
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The molecular genetics of Type 2 diabetes
Type 2 diabetes has a substantial genetic component. The aim of this dissertation was to investigate the molecular basis of Type 2 diabetes with particular emphasis on the role of the glucokinase gene. Other work studied specific mutations in the tRNA<sup>Leu(UUR)</sup> gene of mitochondrial DNA …
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Novel Modulation of Adenylyl Cyclase Type 2
… to modulate recombinant adenylyl cyclase(AC) type 1 and 2 signaling in HEK293 cells following both acute and persistent activation of the D <sub>2L</sub>dopamine receptor (D<sub>2L</sub> DR). AGS3 expression modestly enhanced the potency of acute quinpirole-induced D<sub> 2L</sub>DR modulation …
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A study of type-2 fuzzy clustering
… algorithm for a long time. It was extended to a type-2 framework by the linguistic fuzzy C-means (LFCM) algorithm that operates on vectors of fuzzy numbers utilizing the extension principle, the decomposition theorem, and interval analyses. The purpose of this thesis is to investigate the …
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Transcription of herpes simplex virus type 2
Summary available: p. i-iv.
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Treating type 2 diabetes through insulin resistance
Type 2 diabetes is an insidious disorder, with micro and/or macrovascular and nervous damage occurring in many patients before diagnosis. This damage is caused by hyperglycaemia and the diverse effects of insulin resistance. Obesity, in particular central obesity, is a strong pre-disposing factor …
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Effects Of Sustained Release Somatostatin Type 2 Antagonism On Glucagon Counterregulation And Glycemia In Type 2 Diabetic Rate Model
… protect against hypoglycemia in a rat model of type 2 diabetes (T2D). Male Sprague Dawley rats were placed on a high-fat diet and injected with streptozotocin to induce T2D. The rats were then chronically treated with varying doses of ZT-01 or vehicle using implanted mini-osmotic pumps. While …
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Type-2 Fuzzy Logic: Circumventing the Defuzzification Bottleneck
Type-2 fuzzy inferencing for generalised, discretised type-2 fuzzy sets has been impeded by the computational complexity of the defuzzification stage of the fuzzy inferencing system. Indeed this stage is so complex computationally that it has come to be known as the defuzzification bottleneck. The …
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Genetic association between schizophrenia and type-2 diabetes
… there is a close link between schizophrenia and type-2 diabetes (T2D). Patients with schizophrenia have a high risk of T2D. In order to clarify a genetic association between these two conditions, this study was designed to investigate a genetic pathway that might be associated with both …
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Mitochondrial and chromosomal genomics in type 2 diabetes
… mechanisms of complex polygenic diseases like type 2 diabetes (T2D) is as complex as their nature. Cellular processes involved in glucose homeostasis need high and reliable energy supply. Mitochondria are the major energy producers in mammalian cells. Since majority of the mitochondrial genes …
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The primary care consultation in type 2 diabetes
Type 2 diabetes is a common condition that is associated with high rates of morbidity, mortality and healthcare costs. Multifactorial management has been shown to be effective in preventing complications and inducing remission or cure of the disease. Despite this, the rate of new cases and the …
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Immune modulation mechanisms of porcine circovirus type 2
… throughout the world. Porcine circovirus type 2 is the causative agent of PCVAD; however the presence of PCV2 alone is rarely enough to cause clinical disease. In order for the full development of PCVAD the presence of a co-infecting pathogen is required. The mechanisms by which …
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Type 2 Diabetes And Insomnia: Impact On Metabolic Control
… and quality of sleep to glycemic control in type 2 diabetics. No research on the impact of insomnia on diabetes prevention and/or management was found in the literature. The purpose of this 11 week intervention study was to examine the effects of participation in Cognitive Behavioral Therapy …
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Therapeutic Approaches to Insulin Resistance and Type 2 Diabetes
Type 2 diabetes is a chronic metabolic disorder primarily caused by a systemic insulin resistant state to which obesity is a major contributor. Increasing visceral adipose tissue augments adipokine secretion provoking an enduring low-grade inflammatory response that negatively impacts on the …
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Mechanisms of defective insulin secretion in type 2 diabetes
… the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. This thesis uses a combination of gene network analysis and cell-physiological techniques to explore the genetic …
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Exercise capacity with special reference to type 2 diabetes
… (NGT), impaired glucose tolerance (IGT) and with type 2 diabetes (T2D) was the influence of insulin sensitivity on exercise capacity studied (Study III). Exercise testing and exercise training in individuals with T2D was examined in a group of middle aged women with T2D in study IV and V. The …
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