Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Type 1 diabetes (T1D)"”.
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The Impact of Depressive Symptoms on Healthcare Utilization and Charges for Adolescents with Type 1 Diabetes (T1D)
… costs. Given the growing economic burden of diabetes (approximately $200 billion annually) and that type 1 diabetes (T1D) contributes a disproportionately large share to these costs, factors associated with higher costs in this population should be examined. The present study examines the …
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Overwhelming responsibility : divorced mothers of children managing type 1 diabetes with their children
… Divorced mothers may have challenges managing of type 1 diabetes (T1D) for their children. The purpose of this study was to examine the processes by which divorced mothers with children diagnosed with T1D manage the disease. Open-ended interviews were conducted with 12 mothers who collectively had …
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Impacts of Empagliflozin (EMPA) Treatment on Skeletal Muscle Microvasculature in Type 1 Diabetic Rats
In individuals with type 1 diabetes (T1D) and models of the disease, hyperglycemia is associated with microvascular complications, including reduced capillary ratio in skeletal muscle (SM). We investigated whether a blood glucose lowering drug, empagliflozin (EMPA), has any impact on the …
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Joint whole exome sequencing and linkage analysis in a multigenerational family segregating Type 1 Diabetes
Backround: Type 1 diabetes (T1D) is a complex autoimmune disease with a strong familial segregation. On the other hand, the recent and rapid increase in incidence is a proof of the importance of environmental factor in the etiology of disease. Linkage and Genome-wide association studies had …
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The Timing of Walking and Post-Meal Blood Sugar Levels in Adults with Type 1 Diabetes
… a meal can pose a challenge for individuals with type 1 diabetes (T1D). This thesis examined whether, compared to being sedentary, a 20-minute moderate-intensity walk pre- or post-dinner could reduce postprandial glucose excursions. Eleven adults with T1D using hybrid closed-loop systems (HCLS) …
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BLOOD GLUCOSE MONITORING AND METABOLIC CONTROL IN YOUTH WITH TYPE 1 DIABETES: RELATION TO DISEASE CARE
Better disease care behaviors in youth with type 1 diabetes (T1D) are strongly related to better metabolic control (HbA1c). However, HbA1c results are only available, on average, every three months, and may not accurately capture intricacies of blood glucose fluctuations. Youth then must rely on …
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Epigallocatechin Gallate in the Regulation of Insulin Secretion
In both Type 1 diabetes (T1D) and Type 2 diabetes (T2D), inadequate beta-cell mass and beta-cell dysfunction lead to impaired insulin secretion, and ultimately worsen glycemic control. Green tea has drawn wide attention due to its possible health-promoting properties, including enhancement of …
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DEVELOPMENT OF PREDICTIVE MODELS FOR DIABETICS IN ROUTINE LIFE AND EMERGENCY SITUATIONS
… and control. Particularly, in the recent years, diabetes care has been investigated from a systems perspective in order to shift the conventional treatment strategies towards a proactive mode. Diabetes management includes safer maintenance of blood glucose (BG) levels on a daily basis and also …
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Automating Health: The Promises and Perils of Biomedical Technologies for Diabetes Management
Type 1 Diabetes (T1D) is an irreversible chronic autoimmune disease that affects millions in the United States. Individuals with T1D rely on biomedical technologies to manage their disability and to stay alive. The increased use of and reliance on automated technologies creates complex …
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EARLY-LIFE EXPOSURES TO SPECIFIC COMMENSAL MICROBES TRAIN THE IMMUNE SYSTEM AND PREVENT TYPE 1 DIABETES
… that dominate the early-life microbiome of diabetes-protected NOD/Eα16 mice confers protection from developing type 1 diabetes (T1D) in diabetes-susceptible NOD mice. PedsCom colonization induces weaning-associated peripheral regulatory T cells (pTregs) in the intestines and pancreatic lymph …
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Accelerating data-driven discovery in type 1 diabetes: an informatics-based approach
Type 1 diabetes (T1D) is a lifelong chronic disease characterized by the absolute or near-absolute loss of insulin. For affected individuals, management of T1D is an unremitting challenge that involves constant blood glucose monitoring and lifelong administration and titration of exogeneous …
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Effects of 5��-Dihydrotestosterone (DHT) on Mouse Gut Microbiome– A Study of Sex Differences and Hormonal Effects on Gut Microbiome Composition
<p>Type 1 Diabetes (T1D) is a polygenic and multifactorial disease, traditionally attributed to genetic susceptibility and diet. Over the past decade, novel studies have placed a higher significance on the role of gut microbiome in T1D pathogenesis. Furthermore, diabetic mouse models have shown …
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Type 1 diabetes in children - risk factors and prediction.
… factors are important for development of Type 1 diabetes (T1D). Increased birth weight (BW), increased linear growth and gestational infections are among the reported risk factors. T1D is predictable by analysis of HLA genotypes and islet cell autoantibodies. In this thesis risk factors …
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Molecular Mechanism of MDA5 RNA Sensing in Innate Immunity and Disease Pathogenesis
… Cryo-electron microscopy structures of wild-type (WT) and M854K MDA5-dsRNA filaments provided detailed insights into how the M854K mutation hinders conformational changes necessary for ATP hydrolysis and dissociation from endogenous RNAs, resulting in constitutive activation of signalling …
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Dose-Response Effects of Working Memory Training Among Adolescents with Type 1 Diabetes
Type 1 diabetes (T1D) is a chronic disease that is due to the dysregulation of glucose in the blood when insulin is not made endogenously. Patients rely on a combination of exogenic insulin, medications, blood glucose monitoring, and healthy lifestyle activities such as dietary control and exercise …
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Sociodemographic risk factors of glycemic control for youth with T1D: Cross-sectional and longitudinal patterns of HbA1c
… trajectories of glycemic control and diabetes care of youth with Type 1 Diabetes (T1D) over three years. IGC modeling allowed comparison of confounded sociodemographic predictors of disease outcomes that included ethnicity, SES, parent marital status, family structure, as well as …
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Novel cardiovascular risk factors in childhood
Individuals with type 1 diabetes (T1D) have a 2 to 3-fold increased risk for cardiovascular disease compared to non-diabetic subjects. Exposure to a broad panel of risk factors in childhood may cause vascular damage with potentially long-term consequences for cardiovascular morbidity. The aims of …
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Beta Cell Heterogeneity in the Acute Interferon Alpha Response
Type 1 diabetes (T1D) is characterized by autoimmune destruction of the insulin-producing β-cells in the pancreatic islet. This autoimmunity is hypothesized to result from a combination of genetic and environmental factors, with early childhood viral infection being a leading hypothesis for the …
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Statistical co-analysis of high-dimensional association studies
… of association across this range of phenotypes requires co-analysis of high-dimensional association studies in order to characterise shared and distinct elements. In this thesis I address several problems in this area, with a general linking aim of making more efficient use of available …
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The Disque Platform for the investigation of islet differentiation to study, treat, and cure Type 1 Diabetes
… numbers of beta cells for transplantation. In Type 1 Diabetes (T1D), insulin-producing beta cells in the islets of Langerhans within the pancreas, which support glucose homeostasis, are destroyed in an autoimmune attack. The ensuing loss of glycemic control leads to serious complications, …
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