Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 944 for “"Type 1"”.
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Multimodal Prediction of Type 1 Diabetes
Type 1 diabetes often presents abruptly with life-threatening symptoms; however, its autoimmune pathogenesis typically unfolds over many years. After autoimmunity has been established, the rate of progression to clinical disease varies markedly between individuals, creating both an opportunity and …
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Aspects of autoantibody epitopes in type 1 diabetes
Type 1 diabetes (T1D) is strongly associated with autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to …
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Type 1 hot corrosion furnace testing and evaluation.
… coating systems was conducted to determine if type 1 hot corrosion seen in operating gas turbine engines and burner rigs could be more simply reproduced. Furnace parameters were varied to determine optimum (most aggressive) values for a short term type 1 hot corrosion test. The results of these …
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Understanding the pathogenesis of myotonic dystrophy type 1
… to mimic the pathogenesis of myotonic dystrophy type 1 with temporal and spatial control: temporal to reproduce the developmental pathogenesis of the congenital form, and spatial to isolate tissue specific pathology. To do this, we attempted to use the Cre-lox system for the conditional …
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Genetic contribution to type 1 diabetes microvascular complications
Type 1 diabetes (T1D) is an autoimmune disease characterized by destruction of beta cells in the pancreas resulting in insulin deficiency, which leads to hyperglycemia and organ damage. T1D patients experience an increased risk of morbidity and mortality due to long-term complications, specifically …
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Molecular analysis of innate immunity in type 1 diabetes
Introduction: Type I diabetes (T1D) is an autoimmune disease of children and young adults that selectively destroys the insulin-producing islet cells in the pancreas. NOD mice, the best validated animal model of T1D, manifests islet infiltration as early as 4 weeks, leading to β-cell destruction …
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Poor glycaemic control in adolescents with type 1 diabetes
Many adolescents with type 1 diabetes (T1DM) have suboptimal glycaemic control, increasing the risk of diabetic complications. This thesis explores some of the causes, consequences and therapeutic options for adolescents with T1DM and poor glycaemic control. Insulin resistance occurs in T1DM and …
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Type-1 diabetes risk prediction using multiple kernel learning
… analysis of multiple kernel learning (MKL) for type-1 diabetes risk prediction. MKL combines different models and representation of data to find a linear combination of these representations of the data. MKL has been successfully been implemented in image detection, splice site detection, …
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Type 1 diabetes in children - risk factors and prediction.
… factors are important for development of Type 1 diabetes (T1D). Increased birth weight (BW), increased linear growth and gestational infections are among the reported risk factors. T1D is predictable by analysis of HLA genotypes and islet cell autoantibodies. In this thesis risk factors …
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Association of autoimmune thyroid disease and type 1 diabetes
Overt autoimmune hyperthyroidism and hypothyroidism were found three times more commonly in insulin-dependent than in non-insulindependent diabetics. Similarly, clinically unrecognised primary autoim¬ mune thyroid failure, as evidenced by elevation of the serum thyrotro¬ phs concentration, was …
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Prediction and Detection of Hypoglycaemia in Type 1 Diabetes
Patients with Type 1 Diabetes still suffer from recurrent and troublesome hypoglycaemia despite improvements in glucose monitoring, insulin delivery and structured education. The key objectives of my thesis were to explore ways to identify patients at greater risk to develop hypoglycaemia and to …
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Development of therapeutic agents for myotonic dystrophy type 1
Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder which is caused by a dominantly inherited (CTG·CAG) repeat expansion in the 3’-UTR of the Dystrophia Myotonica Protein Kinase (DMPK) gene on chromosome 19. The genetic basis of DM1 is that DMPK is transcribed into an mRNA …
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CARDIAC ENERGY METABOLISM IN ISCHAEMIA AND TYPE 1 DIABETES
… a different paradigm of metabolic disease, the type-1 diabetic heart becomes more dependent upon the oxidation of fatty acids (FAO) for ATP synthesis due to an inability to regulate blood glucose concentration. The work presented in this thesis aimed to further our understanding of substrate …
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Glycaemic control in pregnancies complicated by type 1 diabetes
Type 1 diabetes in pregnancy is associated with higher rates of maternal and infant complications. The complications are associated with maternal hyperglycaemia. Thus, the main goal of treatment for these women is to optimise glycaemic control and thereby improve clinical outcomes for themselves …
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Early life phenotypes of type 1 diabetes genetic risk
… studies have shown that children who develop type 1 diabetes (T1D) have larger size at birth — a marker of foetal growth — or rapid postnatal weight gains. Recent studies have explored the contribution of the T1D susceptibility human leukocyte antigen (HLA) alleles, which explain half of …
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The genetics of type 1 diabetes: family and population studies
Type 1 (insulin-dependent) diabetes mellitus is caused by autoimmune destruction of insulin-producing pancreatic ß-cells. Genetic susceptibility is necessary for the development of type 1 diabetes but inheritance does not follow simple Mendelian rules and environmental factors are also involved. …
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Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
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Microencapsulated human islets as a therapy for type 1 diabetes
… are to become a viable option as a therapy for type 1 diabetes in humans.
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The role of inflammation in type 1 diabetes-related complications
Contains fulltext : 302597.pdf (Publisher’s version ) (Open Access)
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