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Showing 1 to 2 of 2 for “"Two-step mechanism of nucleation"”.
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Physicochemical Aspects of the Two-Step Mechanism of Nucleation in Protein Solutions
Protein-rich liquid clusters exist in solutions of numerous proteins. They play the role of nucleation precursors of ordered solids of both folded proteins and partially misfolded chains. Examples include protein crystals, sickle-cell hemoglobin polymers, and amyloid fibrils. The clusters hold the …
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Preparation and stability of organic nanocrystals. Experimental and molecular simulation studies.
A major challenge affecting the likelihood of a new drug reaching the market is poor oral bioavailability derived from low aqueous solubility. Nanocrystals are rapidly becoming a platform technology to address poor solubility issues, although several challenges including stabilisation and control …