Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Two compartment model"”.
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Using a voxel-based krogh cylinder array to simulate microvascular contrast enhancement
… Specifically, errors imposed by the traditional two-compartment model are reduced by introducing a novel Krogh cylinder network. The two-compartment model was developed for macroscopic pharmacokinetic analysis of dynamic contrast enhancement and generalizing it to voxel dimensions, due to the …
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Models describing ruminal in situ digestion as affected by the lag process and fractionation of substrate
Models describing ruminal in situ digestion are used frequently to evaluate the nutritive value of feedstuffs. Most models assume the existence of a soluble, a potentially digestible, and an indigestible fraction. Some models include a discrete lag time to account for a delay in disappearance when …
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Intake, growth and rate of digesta passage in ruminating calves fed sodium bicarbonate and disodium phosphate
… to the control group, six to the centerpoint, two to the radial points and three to the single factor points with restrictions as to time. Animals were on a growth trial from wk 7 to 14. Human samples were taken for determination of pH, buffering capacity, volatile fatty acids anct ruminal …
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Design of novel drug delivery system and optimal dosage regimens
… analyzed to emphasize the roles of mathematical models and computer-aided simulations in pharmaceutical research. In the first project, a protocol was developed so that the optimal regimen, consisting of the intravenous boluses and subsequent infusion of theophylline, could be obtained once …
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Design of drug delivery strategies based on well-stirred experiments
… stirred vessel experiments that mimic one- and two-compartment pharmacokinetic models. A one-compartment model assumes that drug is evenly distributed in the body, which is represented by a beaker with an inlet and an outlet stream. In a two- compartment model, drug is distributed between the …
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Probing the effect of microstructure on water diffusion in engineered or biological materials with MRI
… operates and MRI spatial resolution, the use of model systems is required in order to develop the methodology for deriving quantitative information from MRI data. Some engineered materials and systems share certain structural or functional characteristic with skeletal muscles and therefore can be …
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Effect of penicillin G on the reproduction of Salmonella cholerasuis in the presence and absence of porcine alveolar macrophages in a pharmacodynamic model
… this research project was to modify an in vitro model for examining the effects of changing penicillin G concentrations on the reproduction of logarithmic growing Salmonella cholerasuis in the presence and absence of porcine alveolar macrophage (PAM). The results of an intra-arterial penicillin G …
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Investigation into the partitioning of Lindane between air and dust in indoor environments
… from the dynamic adsorption tests to an existing two compartment model described in chapter 2, using the statistical analysis software SPSS (vs16). These dynamic tests were carried out for two size fractions (<20µm and >45µm<63µm) and whole dust samples to determine the effect of size fraction on …
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A plethysmographic device for determining human body volume and body density
… of fat mass (FM) and fat free mass (FFM) for the two-compartment model. The standard method for determining body volume (and hence body composition) is the densitometric (underwater weighing) technique based on Archimedes' principle. Three variables, notably residual lung volume (RV), total body …
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Event-Driven Motion Compensation in Positron Emission Tomography: Development of a Clinically Applicable Method
… R0k3 rates of an irreversible reference tissue two compartment model. Thus, it could be shown that an integration of a motion compensation method which is based on the utilisation of the raw data of a PET scanner, as well as the use of an external motion tracking system, is not only reasonable …
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Paediatric Dexmedetomidine Pharmacology
… were estimated using non-linear mixed effects models. Parameter estimates for a two-compartment model were: clearance (CL) 39.2 (30.4%) L.h-1.70kg-1, central volume of distribution (V1) 36.9 (69.5%) L.70kg-1, intercompartment clearance (Q) 68.2 (37.6%) L.h-1.70kg-1, and peripheral volume of …
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Pharmacokinetics of neostigmine and pyridostigmine in man.
… and the data was interpreted in terms of a two compartment model. The slow disposition halflife of the drug was progressively prolonged as the dose of the drug was raised from 36.2 Ng/kg to 144.8 jig/kg. A similar increase in the half-life was observed in cross-over studies. The clearance of …
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Quantification of Myocardial Perfusion Based on Signal Intensity of Flow Sensitized MRI
… region of interest is related to perfusion via a two-compartment tissue model. But accurate determination of T1 in small animal hearts is difficult and prone to errors due to long scan times. The purpose of this study is to develop a fast, robust and simple method to quantitatively assess …
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The combined toxic effect of nanoparticles and lead in the presence of algae (Raphidocelis)
… <em>C. dubia</em>. The second paper develops a two-compartment kinetic model to quantify the iron (Fe) and Pb accumulation in <em>C. dubia</em> in the presence of nano-TiO<sub>2</sub>. The model was used to investigate the major uptake, depuration, and distribution pathways of Fe and Pb in …
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Population Pharmacokinetics of Therapeutic Monoclonal Antibodies: Examples and Estimation Method Performance Differences
<p>Over the past two decades, there has been an increase in the research and development and therapeutic application of monoclonal antibodies (mAbs). An application of pharmacokinetic (PK) and pharmacodynamic concepts that has likely contributed to the success of the pre-clinical and clinical drug …
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Manganese-enhanced magnetic resonance imaging in cardiometabolic disorders
… was assessed in 10 healthy volunteers. In study two, we compared myocardial manganese uptake in patients with either type 1 or type 2 diabetes without cardiac disease versus healthy volunteers. Manganese-enhanced cardiac magnetic resonance imaging was performed in people with type 1 diabetes …
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Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation in the Development of Spectinamides, a Novel Class of Anti-Tuberculosis Agents
… efficacy in <em>(Mtb)</em>-infected mouse models. Pharmacokinetic (PK)/ pharmacodynamic (PD) analyses play a critical role in identifying the optimum dosing regimen for new treatments. In this dissertation, I hypothesized that the application of translational PK/PD modeling and simulation …
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Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach
… collected serum concentration-time data from two previous studies (Study 1 and Study 2) published by our research group. Hospitalized, adult patients who required antimicrobial therapy for a suspected or documented bacterial infection were eligible to participate in both studies. In Study 2, …