Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Two Pore Channels"”.
-
Interactions between Human Two-pore Channels and Nonaspanin Proteins
… a nine-spanning transmembrane protein and human two-pore channels (TPCs) regulate cell autophagy. More importantly, TM9SF1 and TPCs are found in endolysosomal system, and among all TM9SF family, only TM9SF1 interacts with TPC2 structurally, which suggests that there might be functional …
-
Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium
… which mediates this pathway via activation of two pore channels. Modulation of Ca2+ release from acidic stores may serve as a potential target for treating IBD and other gastrointestinal pathologies.
-
Ionic Mechanism of Lysosomal Function and Cell Metabolism
<p>Two Pore Channels (TPCs) are endolysosomal ion channels that are permeable to sodium and calcium. Defects in TPCs have been implicated to impair vesicle trafficking, autophagy and cell metabolism control; however, the detailed mechanism remains largely unknown. In this study, I show that TPCs …