Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 949 for “"Tumours"”.
-
Canine Mast Cell Tumours: Characterization of Subcutaneous Tumours and Receptor Tyrosine Kinase Profiling
This work explored features of canine mast cell tumours (MCT) to improve prognosis and to discover potential therapeutic targets. Subcutaneous MCT - a subset of these tumours arising in the subcutis - are usually grouped with cutaneous MCT, but there is evidence that they may be clinically …
-
Biochemical studies on Oestradiol 17β in human mammary tumours and chemically induced rat mammary tumours
… labelled oestradiol 170 by certain mammary tumours is due to the possession of specific oestradiol binding components similar to those occurring in normal oestrogen target tissues such as uterus. The possession of such components may be related to the hormone responsiveness of the tumour. An …
-
Targeting Myc-driven tumours - BETing on ATR
… found to be deregulated in more than 70% of the tumours. Targeting MYC directly or identifying the Achille’s heel of MYC-driven tumours is thus a promising therapeutic approach to treat these tumours. This thesis investigates and demonstrates novel therapeutic approaches against MYC-driven …
-
Genetic and Epigenetic Characterisation of Breast Tumours
Breast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. The heterogeneity of breast tumours is reflected in the identification of at least five molecular subtypes named basal-like, luminal …
-
Molecular biology and biochemistry of brain tumours
… molecular mechanisms and biochemistry of brain tumours is an important step towards the development of adjuvant medical therapies. The present study concentrates on cholecystokinin (CCK), a gut-brain peptide that has been described to be able to induce mitosis of rat gliomas as well as hormone …
-
The experience of low grade and pituitary tumours
Low grade brain tumours make up approximately 45% of all brain tumour diagnoses each year in the UK, of which 10% are pituitary tumours. People with low grade and pituitary tumours can experience a wide range of physical, psychological and cognitive difficulties. Studies have reported mixed results …
-
Genetic basis of inherited kidney and related tumours
… proband and other sporadic *ELOC*-mutated RCC tumours in the 100KGP and the literature. Five additional novel candidate genes (*CTTN*, *DMXL1*, *MUC17*, *GANAB* and *DET1*) were identified in other probands, all with missense *de* *novo* variants, which require validation in larger cohorts …
-
Targeting oncogenic microRNAs in malignant germ cell tumours.
Malignant germ cell tumours (mGCTs) are a heterogenous group of tumours that occur primarily in the testes and ovaries but also in other anatomical sites, and affect people of all ages. It was established by the Coleman group through microRNA profiling in 2010 that all mGCTs, regardless of tumour …
-
Ependymal tumours in childhood: outcomes and prognostic factors
… patients were male (66,7%), had infratentorial tumours (62,7%) and had low-grade tumours (70,6%). Gross total resection (GTR) was achieved in 22 patients (43,1%). Thirtyeight patients received adjuvant radiotherapy (76,5%) and 10 (19,6%) received adjuvant chemotherapy. RESULTS: The 5-year …
-
Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
… a high resolution for cytogenetic analysis of tumours with chromosomal instability could be obtained. This combined approached was used also to search for reciprocal translocations leading to fusion genes in Wilms tumour. Although the technique proved efficient, no recurrent reciprocal …
-
The Investigation of Targets for Therapy in Brain Tumours
Gliomas are among the most difficult of tumours to treat. Their highly invasive nature leads to recurrence even after aggressive therapy including surgery, radiotherapy and chemotherapy. A promising target for new therapies are tyrosine kinases, because they regulate a large range of proteins …
-
Identifying Common Therapeutic Targets in Merlin-deficient Brain Tumours
… individuals to develop multiple nervous system tumours, primarily schwannoma, meningioma and ependymoma. NF2 is characterised by loss of the tumour suppressor protein Merlin, caused by bi-allelic mutations of the encoding gene NF2 or by loss of heterozygosity. These tumours can occur either …
-
Diagnostic Neuropathology of Brain Tumours using Biophotonics and Spectrometry
Classification of tumours such as gliomas, which are on a continuous spectrum of histology and malignancy into distinct categories is still a challenge using histopathology. There has been significant advances in the techniques used to fight cancer in the past two decades. A number of studies have …
Page 1 of 48