Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Tumour-targeting"”.
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Antibody engineering to evaluate binding, internalisation, and intracellular routing of tumour-targeting fusion proteins
… chondroitin sulphate proteoglycan 4 (CSPG4), a tumour-associated antigen often overexpressed in TNBC. The scFv antibody derivative was genetically fused to a SNAP-tag, enabling stable and site-specific conjugation of the scFv to diagnostic and therapeutic substrates. To enhance antigen binding, …
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Investigation of orally administrable bacteria for cancer therapy
… ability of bacteria to selectively colonise tumours following IV administration and replicate therein. Based on this property, bacteria have been studied both clinically and preclinically to evaluate their potential to promote tumour regression and confine noxious effects to the malignant …
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Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer
… in PDT. They are also known to accumulate in tumour tissue due to the hyperpermeability of tumour vasculature and poor lymphatic drainage, thus exhibiting a passive tumour targeting property. Functionalised tetraazamacrocycles based around the cyclam and cyclen structures form …
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Investigating the size effect of nanoparticles in Click Chemistry mediated cancer targeting
… accumulation and retention in the tumour tissue. The effect of NP size on tumour targeting has been studied in various contexts, with or without a targeting mechanism incorporated. Herein, we report our investigation of the size effect of NPs in Click Chemistry mediated cancer …
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Investigation of a fusogenic pH-sensitive liposomal system for tumour-targeted intracellular delivery of dinitrobenzamide mustard prodrugs
… the mainstay treatment for cancer, non-selective tumour targeting leads to severe side effects. The unique characteristic of solid tumours, such as low pH, hypoxia and the leaky vasculature, may be exploited as triggers to improve therapeutic outcomes. Dinitrobenzamide mustard (DNBM) prodrugs, …
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Ex vivo culture of patient tissue and examination of gene delivery
… of cancer due to its potential for selective tumour cell targeting. The greatest challenge gene delivery vectors face is the ability to safely and efficiently deliver genes into target cells. The overall objectives of this thesis are to evaluate the efficacy of various gene delivery methods in …
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Novel approaches and pharmacological considerations in melanoma treatment
… and anti-PD-1 antibodies, which enhance tumour T-cell activity, and selective BRAF (DBF; dabrafenib) and MEK (TRA; trametinib) inhibitors, that block tumour growth in patients with active BRAF mutations. Although these therapies offer significant improvement in treating melanoma patients, …
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The development of a radiolabelled macromolecule as a therapeutic agent for the treatment of cancer
… macrocycle (cyclam), ii) lead to passive tumour targeting via the EPR effect and a suitably large carrier such as human serum albumin and iii) induce active targeting through a glucose moiety recognised by the over-expressed glucose transporters on the surface of highly metabolically …
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In vitro investigation of the effect of disulfiram on hypoxia induced NFκB, epithelial to mesenchymal transition and cancer stem cells in glioblastoma cell lines
… and by actions of the normal brain to counteract tumour-targeting medications. Hypoxia is common in malignant brain tumours such as GBM and plays a significant role in tumour pathobiology. It is widely accepted that hypoxia is a major driver of GBM malignancy. Although it has been confirmed that …
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Photoimmunotheranostic targeting of CSPG4-positive melanoma cells using SNAP-tag technology
… fusion of this self-labelling protein with a tumour targeting antibody, we developed a recombinant immunoconjugate able to carry BG-modified photosensitizers to selectively target and eliminate malignant melanoma cells. Conjugation of the SNAP-tag fusion protein with the fluorescent dye Alex …
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CRISPR/Cas9-mediated ATG7 knockout results in enhanced osteosarcoma chemosensitivity
… show strong evidence to suggest that in advanced tumours autophagy is employed to aid cells in their progression and survival. Upon chemotherapy introduction, autophagy is upregulated to overcome stresses induced by anti-cancer drugs and facilitates tumour cells survival, progression and …
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Designing a safe dendronised polymeric nanocarrier for hydrophobic drugs or gene delivery in cancer therapy
… known to be the most effective treatment, lack tumour specificity and suffers from poor solubility. The lack of specificity results in severe side effects in off-target tissues, whereas poor soluble drugs exhibit short half-life in the bloodstream and high overall clearance rate. Amphiphilic …
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Risk stratification in the management of localised prostate cancer treated with radical radiotherapy
… post-prostatectomy setting. In contrast to other tumour sites, however, commonly employed methods of risk stratification have not changed significantly and certainly have not kept pace with these advances in management. <br/><br/>The hypothesis that underpins this work is that precision medicine …
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Investigating the role that Interleukin-10's receptor binding properties play in defining its biological activities
… shown, under certain conditions, to enhance the tumour targeting ability of CD8 T cells (Naing et al., 2018) however much is still unknown about this process. We used proteomics as well as RNA sequencing to examine the action of IL-10 in human CD8 T cells. This study showed that IL-10 can …