Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Tumour-associated macrophages (TAMs)"”.
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… development of CRC is highly influenced by the tumour microenvironment. Tumour cells are able to recruit macrophages and change their behaviour. These tumour-associated macrophages (TAMs) were of the M2 phenotype (CD206+). In CRC patient tissues and xenografts from mouse model, presence of …
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Oxime Click-crosslinked Cryogels to Quantify and Target Tumour-associated Macrophage Invasion in Hodgkin Lymphoma
… cancer cells account for less than 5% of the tumour microenvironment, yet drug screening and treatment strategies typically focus on targeting malignant cells. Tumour-associated macrophages (TAMs) are associated with poor prognosis and resistance to therapy; however, there remains an unmet …
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Exploring the immune landscape of the tumour microenvironment in meningiomas and the role of immune infiltration in meningioma models
… are the most common primary intracranial tumours, ranging from benign to highly aggressive forms. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic approaches. …
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CD68-positive tumour associated macrophages, PD-L1 expression, and EBV latent infection in a high HIV-prevalent South African cohort of Hodgkin lymphoma patients
… and aims A higher proportion of CD68-positive tumour associated macrophages (TAMs) has been associated with poorer outcomes in HIV-negative patients with Hodgkin lymphoma (HL), but whether this is true in HIV positive patients with HL is not known. In this study, we investigated the number of …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
This project focuses on two tumours of the nervous system, schwannoma and meningioma. A large group of schwannomas and meningiomas display the inactivation of the NF2 gene. The NF2 gene codes for the tumour suppressor protein Merlin and its loss is associated with a multitude of pro-tumourigenic …
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The role of stromal cells in the establishment of Glioblastoma tumour microenvironment immunosuppression
… is the most aggressive, fatal, yet most common tumour to affect the central nervous system in adults. With a median survival time of only 15 months following diagnosis, it is a disease of high morbidity and mortality. Immunotherapies have shown great promise in the treatment of other …
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Investigation of the role of Col4a1 and Itga11 in enzalutamide resistance of prostate cancer cells
… and accounts for over 90% of PCa-related deaths. Tumour-associated macrophages (TAMs) can promote ADT resistance in bone metastasis, but the mechanism is yet unknown. Recent studies in our lab have identified that macrophages regulate the expression of a set of extracellular matrix genes that are …
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Role of the extracellular matrix-integrin interaction in enzalutamide resistance of bone metastatic castration-resistant prostate cancer
… options for bone mCRPC patients. Although tumour-cell autonomous mechanisms are increasingly understood, roles played by the tumour microenvironment (TME) in driving Enz-resistance remain less clear. Previous has research revealed that macrophages, as a major TME component, are important in …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… regeneration. Hypothesis: We hypothesised that Tumour-associated macrophages (TAMs), a distinctive cell type within the tumour microenvironment, could represent an innovative therapeutic approach for neuro-regenerative medicine. Indeed, TAMs possess a unique set of properties, including immune …