Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"Tumour size"”.
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C/EBPβ Regulates Tumour Size and Microenvironment Composition in Lewis Lung Carcinoma
… C/EBPβ has been implicated in both oncogenic and tumour-suppressive functions across different cancer types, its role in lung cancer, particularly in the widely used Lewis lung carcinoma (LLC) model, remains poorly defined. The objective of this study was to define the role of C/EBPβ in LLC tumour …
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Neoadjuvant endocrine therapy for estrogen receptor positive breast cancer in an African setting
… a biopsy-proven breast cancer less than 50mm in size on clinical exam. Results There were 16 patients included in the study, of which all were female. The mean age was 59 years (range 41-75). When comparing the histological measurement to initial size on imaging, 7 patients had an excellent …
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The clinical characteristics, presentation, and treatment outcomes of prolactinomas at Groote Schuur Hospital
Background: Prolactin-secreting tumours( prolactinomas) are the commonest type of pituitary tumour, accounting for approximately 30 to 40 %% of all pituitary adenomas. Although there is ample epidemiologic and clinic data from Industrialised countries there remains sparse data from Africa. …
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Retrospective study at a single tertiary hospital in South Africa (Groote Schuur) on the treatment outcome in patients who underwent TransArterial Chemo-Embolization (TACE) for hepatocellular carcinoma
… radiological features were assessed including tumour size and necrosis in conjunction with AFP levels were evaluated to determine tumour response. Results: During the study period 24 patients (17 males [70.8%] and 7 females[29.2%], with a mean age of 52.9 years) underwent TACE for HCC. 15 …
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Hypoxia regulated pathways in urological malignancies
… in many clear-cell RCCs due to loss of pVHL tumour<br/>suppressor function within the tumour. In vitro, HIF-1 and HIF-2 regulate a differential set of<br/>target genes, although their expression in primary ccRCC clinical samples and their effects on<br/>patient prognosis has yet to be fully …
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HPV and p16 in head and neck cancer
… age group, survival, nodal metastasis and T3 tumour size and smoking. HPV16 was predominantly present in female patients and was associated with an improved overall survival and recurrence free survival. p16 positivity varied from 76-78% in carcinomas, 51% in benign lesions and 66% in …
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Life Style, Molecular Pathology, and Breast Cancer Risk
… breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. A major aim of this …
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Die Wertigkeit mammasonographischer Dignitätskriterien in Abhängigkeit von verschiedenen histologischen Merkmalen und der Tumorgröße
… in differentiating benign from malignant tumours. For ultrasound mammography it could be evaluated a sensitivity of 94,0%, a specificity of 91,4%, a positive predictive value of 95,9% and a negative predictive value of 99,1%. Ten different sonographic criteria were validated separately. …
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The influence of cisplatin dose variations during concurrent weekly chemo-radiation in stage IIB cervical cancer at Groote Schuur Hospital
Objective: To examine the effect of treatment and tumour factors on the overall survival (OS) of patients completing chemo-radiation (CRT) for stage IIB cervical cancer. Materials and methods: Retrospective audit of 228 patients with stage IIB cervical cancer treated between 1995 and 2010, who …
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Quantitative Ultrasound Characterization and Monitoring of Locally Advanced Breast Cancer
Traditional assessment of tumour response to cancer therapy is based on tumour size reduction, which takes several weeks to become clinically significant. In this thesis, novel ultrasound backscatter signal analysis and machine learning techniques were developed to characterize breast tumours and …
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A chemical genetic approach to identify new treatments for melanoma
… This combination led to an enhanced decrease in tumour size when tested in vivo in a mouse xenograft model when compared to either drug alone. Key words; Melanoma, BRAFV600E, leflunomide, cell viability, selumetinib, synergy, combination index value, NCI Diversity Set II, Xenopus laevis.
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Investigation of metabolism in glioblastoma patient-derived xenografts using deuterium metabolic imaging
… provide morphological information, such as tumour size and perfusion. However, they do not provide any information on metabolic activity, which in treated tumours can precede anatomical changes. Position emission tomography (PET) is the only metabolic imaging technique that is currently …
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Mathematical modelling and investigation of oncolytic therapies for cancer: The role of macrophages in tumour-virus interactions
… the virus particles and the host immune cells in tumour-microenvironment. Among these immune cells, macrophages represent one of the first line of defence against viral infections.<br/><br/>In this thesis, we start with a simple model that describes the interactions between a commonly-used …
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Analysis of factors influencing early outcome following liver resection
… (CRLM) to identify factors associated with tumour recurrence and survival. Methods A retrospective review of a prospectively maintained database of patients undergoing liver resection between 2005 and 2012 was performed. Results and Conclusions Over a seven-year period 504 liver resections …
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Describing motions in biological tissues: a continuum active model and improving measurements
… We apply our model to a growing circular tumour. We employ our approach to understand how activity affects the tumour’s dynamics and the tendency to form “fingers” at its boundary. This approach rests on just four key biophysical parameters and we can estimate them based on experiments …
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The role of tissue inflammation in Kenyan women with breast cancer
… the cellular and signalling milieu of BC tumour microenvironment and its associations with BCrisk factors, tumour characteristics and molecular subtypes in Kenyan women with breast cancer. Methods: Molecular subtyping of 838 cases of BC was performed based on Immunohistochemistry (Figure …
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Mathematical modelling of the innate and adaptive immune response to solid tumours
… models describing the growth of a solid tumour in the presence of an immune response are presented. Specifically, attention is focused on the interactions between cytotoxic T-lymphocytes (CTLs) and tumour cells in a small, avascular multicellular tumour. At this stage of the disease the …
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Y-box binding protein-1 (YB-1) is a bio-marker of aggressiveness in breast cancer and is a potential target for therapeutic intervention
… cancer. In the cohort of 4049 primary breast tumours, we show that YB-1 is a strong marker of aggressiveness, poor survival and cancer recurrence in all subtypes of human breast cancer with a particularly high frequency of expression in the ER negative basal-like and HER-2 breast cancer …
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Development of imaging techniques to assess tumour cell death
… an important imaging target for assessing early tumour treatment response and the effectiveness of therapy. Traditionally, anatomical imaging modalities measure changes in tumour size (Response Evaluation Criteria in Solid Tumours (RECIST)). More recently these assessments have also included …
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ESPRESSIONE DI SEL1L NEL CARCINOMA MAMMARIO - CORRELAZIONI CLINICO PATOLOGICHE
… and worse prognostic features, including larger tumour size, higher grade and LN+ status, consistent with more advanced stage at disease diagnosis. Results showed that no clear significant differences between the Sudanese and Italian series were found for SEL1L expression levels combined with …
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