Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Tumour response"”.
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Statistical analysis of end-points in cancer clinical trials
… cancer clinical trials are reviewed. These are: tumour response, treatment morbidity, survival with related data, and quality of life. A survey of tumour response data from 81 published clinical trials found the most common statistical test in use to be a Chi squared test of the total response …
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Quantitative Ultrasound Characterization and Monitoring of Locally Advanced Breast Cancer
Traditional assessment of tumour response to cancer therapy is based on tumour size reduction, which takes several weeks to become clinically significant. In this thesis, novel ultrasound backscatter signal analysis and machine learning techniques were developed to characterize breast tumours and …
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Role of Amplification of Chromosome 6P12-P21 in Human Osteosarcoma
… therapy. It is the most common malignant tumour of bone, predominantly occurring in adolescents. Currently, the mainstay of treatment is surgical resection in combination with multi-agent chemotherapy. Understanding of the genetic basis of osteosarcoma has been impeded by the complex and …
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Mathematical modelling in the scheduling of cancer chemotherapy treatment when drug resistance is present.
… are described in Chapter 4. In order to predict tumour response to chemotherapy in the presence of drug resistance a mathematical model is developed and analysed in Chapter 6 which incorporates mechanisms for tumour growth, cell kill due to the administration of chemotherapy, drug resistance, …
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The role of innate immunity in pancreatic cancer progression and treatment
Immune cells are highly abundant in the tumour microenvironment of pancreatic ductal adenocarcinoma (PDAC) and they significantly influence the entire process of PDAC tumourigenesis. While the anti-tumour response is typically mediated by adaptive immunity, cells of the innate immune system can …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
… (PD-1) to enhance cytotoxic T-lymphocyte response against tumours has been used in the management of several malignancies including metastatic melanoma. Although preliminary studies in patients with untreated metastatic melanoma demonstrated significantly increased progression-free …
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Role of the Innate Immune Response to DNA During Therapy with Oncolytic Viruses
… time as they replicate and spread throughout tumours. Whilst tumour lysis helps reduce tumour burden, a secondary purpose of OVs as immunotherapies is to stimulate the host's immune system culminating in a systemic anti-tumour response. To do so relies on OVs ability to trigger to two distinct …
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Biomarker development for gastrointestinal and ovarian cancer: a proteomic approach
… to individuals, and assessment of treatment response. With this in mind different proteomic approaches were used to identify biomarkers which could potentially aid prognosis and predict response in gastrointestinal and ovarian cancer. Raf Kinase Inhibitor Protein (RKIP) was originally …
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Effect of breathing hypoxic gas mixtures followed by irradiation on tumour cell survival in experimental mouse tumors
It is generally accepted that most tumours contain radioresistant hypoxic cells, which limit the effectiveness of photon radiation. This dissertation outlines an attempt to i increase the sensitivity of mouse tumours to X- and gamma radiation by reducing the fraction of hypoxic cells in tumours. It …
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Clinical resistance to platinum chemotherapy in ovarian cancer
… cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established. We have studied DNA interstrand crosslinking and its repair in response to ex vivo treatment with cisplatin …
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The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics
… advanced breast cancer. The ability to predict tumour response would allow chemotherapy administration to be directed towards only those patients who would benefit, thus maximising treatment efficiency. This project aimed to identify predictive protein biomarkers associated with chemotherapy …
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Functional imaging of cancer using Optoacoustic Tomography
Poor oxygenation of solid tumours has been linked with resistance to chemo- and radio-therapy and poor patient outcomes. Measuring the functional status of the tumour vasculature, including blood flow fluctuations and changes in oxygenation is important in cancer staging and therapy monitoring. A …
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PET-MR Imaging of Hypoxia and Vascularity in Breast Cancer
… provide anatomical or structural description of tumours in the clinical setting. It is widely accepted that the tumour microenvironment influences the phenotype, progression and treatment of breast cancer. This gave the impetus to move beyond tumour visualization in images to radiomics in order …
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Role of Properdin in Tumour Growth and Cell Recruitment
… activation and<br/>has been implicated in the tumour response in human lymphoma and carcinoma.<br/>This project investigated the role of properdin in a syngeneic orthotopic tumour<br/>model in mice engineered to be properdin deficient and their wildtype controls.<br/>The in vitro part of the …
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The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells
… the laboratory to target antigens expressed on tumour cells through the introduction of chimeric antigen receptor (CAR) genes. Despite considerable advances in the treatment of B cell leukaemia using chimeric antigen receptor T (CART) cells targeting the CD19 antigen, some patients have not …
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Proteomic identification of putative biomarkers of radiotherapy resistance
BackgroundCurrently, tumour response to radiotherapy cannot be predicted meaning that those patients with tumours resistant to the therapy endure the harmful side effects associated with ionising radiation in the absence of therapeutic gain. The aim of this project was to identify protein …
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The roles of the chemokines CXCL12 and CXCL16 in breast cancer.
… immunity and hence efficacious anti-tumour immune responses. The aim of this study, therefore, was to further elucidate the roles of CXCL12 and CXCL16 in breast cancer development and metastasis. To achieve this, wild-type CXCL12 and CXCL16 and antagonists of CXCL12 and CXCL16 …
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CD4+ T cell recognition of Epstein-Barr virus nuclear antigen (EBNA) - 1 in the Chinese population
… treatment of nasopharyngeal carcinoma (NPC), a tumour common in southern Chinese people, is dependent on chemo/radiosensitivity. Patients with early stages of the disease are usually chemo and radiosensitive with 5 years survival rates of 90% whereas, patients with late-stages of the disease or …
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Retrospective study at a single tertiary hospital in South Africa (Groote Schuur) on the treatment outcome in patients who underwent TransArterial Chemo-Embolization (TACE) for hepatocellular carcinoma
… compare the imaging and alpha fetoprotein (AFP) responses with previous international studies on treatment response. Objectives:. To elucidate imaging and AFP outcomes after TACE in patients with hepatocellular carcinoma by measuring these in comparison with previous studies. Methods: 24 patients …
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Does inappropriate DNA replication provide a mechanism for the de novo acquisition of drug resistance?
… patient benefit, however ultimately patients tumours develop resistance to targeted treatments. Initial tumour response followed by a period of dormancy before progressing in patients treated by targeted therapies has been modelled in vitro through the drug tolerant persister (DTP) phenotype …
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