Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Tumour necrosis factor alpha (TNFα)"”.
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… in the presence of death ligands, such as tumour necrosis factor alpha (TNFα). I hypothesize that type I interferon (IFN) stimulation in cancer cells and in immune cells leads to the production of TNFα, which can then synergize with SMCs to kill cancer cells. The combined treatment of SMC …
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Bioavailability of blueberry-derived phenolic acid metabolites and their activity in endothelial cells
… and inflammation are important contributing factors of endothelial dysfunction. Therefore, the ability of each mixture to induce cellular antioxidant response proteins regulated by nuclear factor erythroid 2-related factor 2 (Nrf2) or to reduce endothelial cell monocyte adhesion under …
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Functional DNA Aptamers as Biotherapeutic Molecules
… validated therapeutic targets, specifically the Tumour Necrosis Factor alpha (TNFα) and Carcinoembryonic Antigen (CEA), and block their biological functions. As well, I investigated the use of CEA and MUC1 binding aptamers as targeting agents to guide and detect the delivery of contrast …
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Molecular aspects of the link between obesity and endometrial cancer.
… the exact role of intracellular signalling factors within adipose tissue, in the development of endometrial cancer, is still unclear. This project aimed to partially address this lack of understanding by carrying out a systematic review / meta-analysis of primary studies related to the role …
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The protective role of tumour necrosis factor alpha in the heart
The pleiotropic cytokine tumour necrosis factor alpha (TNFα) is produced by the heart in response to the ischaemic preconditioning (PC) stimulus. We hypothesised that this endogenously produced peptide may play a role in activating the ischaemic PC mediated tolerance towards a subsequent ischaemic …
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Metabolism and Body Composition in Chronic Inflammatory Arthritis: Prevention and Intervention through Pharmaceutical and Physical Means
… (RA) is characterised by excessive production of tumour necrosis factor alpha (TNFα). This leads to rheumatoid cachexia, a condition characterised by increased resting energy expenditure (REE) and loss of fat-free mass (FFM) leading to functional disability, decreased strength and balance. The …
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Characterisation of the role of Fas in intestinal inflammation and cancer
… anti-Fas augmented TLR4 and TLR5-mediated tumour necrosis factor alpha (TNFα) and interleukin 8 (IL)-8 production by intestinal cancer cells, suggesting crosstalk occurs between these receptors in these cells. Furthermore, suppression of Fas in intestinal cancer cells reduced the ability of …
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How does pulmonary exposure to particulate matter predispose the heart to increased injury after myocardial infarction?
… levels of two inflammatory mediators, IL-6 and tumour necrosis factor alpha (TNFα) were increased in the plasma by 24 h after exposure. DEP had no affect on blood flow responses to the endothelium dependent dilator acetylcholine (ACh) in rat hind-limb vasculature in vivo at 6 or 24 h. In …