Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Tumour necrosis factor alpha"”.
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The protective role of tumour necrosis factor alpha in the heart
The pleiotropic cytokine tumour necrosis factor alpha (TNFα) is produced by the heart in response to the ischaemic preconditioning (PC) stimulus. We hypothesised that this endogenously produced peptide may play a role in activating the ischaemic PC mediated tolerance towards a subsequent ischaemic …
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Role of Tumour Necrosis Factor Alpha (TNFa) in ischaemic and pharmacological postconditioning
Ischaemic postconditioning (IPostC) is a powerful protective mechanism that activates prosurvival intrinsic signalling cascades to limit reperfusion injury but the exact signalling pathway involved in this cardioprotective effect still remains unclear.
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The effects of Tumour necrosis factor-alpha and Interleukin-1-beta on intracellular calcium handling and contractility in sheep ventricular myocytes
Proinflammatory cytokines such as TNF-α and IL-1β are implicated in the pathogenesis of inflammatory disease states such as sepsis. In sepsis, myocardial depression is a leading cause of death. To design novel therapeutic targets, it is essential that we understand how these cytokines mediate the …
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Regulation of leukocyte adhesion to endothelium / by Jennifer Ruth Gamble.
Shows that the cytokine tumour necrosis factor [alpha] (TNF-[alpha]) enhances the adhesion of neutrophils to the endothelium by an action both on the neutrophil and on the endothelial cell.
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The mechanism of action of tumour necrosis factor-α / Jeffrey A.J. Barbara.
The in vivo adminstration of Tumour Necrosis Factor-alpha as an antineoplastic agent has been severely restricted by dose-limiting side effects. Human TNF mutants with selective binding to the Human TNF receptors were employed to examine the role of these receptors in the mediation of TNF's …
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Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species
Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… in the presence of death ligands, such as tumour necrosis factor alpha (TNFα). I hypothesize that type I interferon (IFN) stimulation in cancer cells and in immune cells leads to the production of TNFα, which can then synergize with SMCs to kill cancer cells. The combined treatment of SMC …
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Regulation of apoptosis in human cancer cells
… cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis and to determine its validity across cancer cell types. In addition, we hoped to explain the involvement of …
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Surface functionalisation of encoded SU-8 microparticles and their uses in multiplexed suspension biological assays
… sandwich suspension immunoassay, human tumour necrosis factor-alpha (TNF-?) and interleukin 6 (IL-6) are detected and compared with conventional enzyme-linked immunosorbent assays (ELISA). Correlation coefficients (R2) for the two cytokines are found to be >0.96. Intra-assay variability …
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Role of Activated Macrophages and Pro-Inflammatory Cytokines in Placental Trophoblast Invasion and Fetal Outcome
… In particular, increased production of tumour necrosis factor-alpha (TNF) by activated macrophages has been implicated as a causative factor mediating various pregnancy complications. Results from this thesis showed that macrophage-derived TNF decreased the invasiveness of trophoblast …
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TNF inhibitors for the prevention of Alzheimer’s disease
… peripherally elevated in both diseases including tumour necrosis factor-alpha (TNFa), a proinflammatory cytokine which has been associated with an increased rate of neurodegeneration and risk of conversion from mild cognitive impairment (MCI) to AD dementia. This led to the development of a …
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TNFalpha expression in monocytes/macrophages
… mediators. One such mediator is the cytokine tumour necrosis factor alpha (TNF). TNF is a pleotropic cytokine with actions ranging from tissue injury to septic chock. This thesis is based on studies performed with the use of different stimuli (either bacteria, the bacterial product LPS or …
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Defining the human immune signature following infection with Crimean-Congo haemorrhagic fever virus
… onset with some biomarkers (particularly Tumour necrosis factor – alpha (TNF-α) and C-X-C motif chemokine ligand - 10 (CXCL10)) remaining elevated in patients of all disease severities for 24-months following infection. Memory T-cell responses were highly variable between patients and not …
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p38 MAPK Signalling in Endothelial Apoptosis
… proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main …
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Co-culture of hepatocytes with mesenchymal stem cells for cellular therapy in liver disease
… established to investigate the role of paracrine factors in hepatotrophic effect of MSCs co-culture. Hypoxia-preconditioned (HPc) MSCs were co-cultured with hepatocytes to investigate potentiative effect of HPc induction. Intracellular reactive oxygen species (ROS) activity quantitation and …
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Bioavailability of blueberry-derived phenolic acid metabolites and their activity in endothelial cells
… and inflammation are important contributing factors of endothelial dysfunction. Therefore, the ability of each mixture to induce cellular antioxidant response proteins regulated by nuclear factor erythroid 2-related factor 2 (Nrf2) or to reduce endothelial cell monocyte adhesion under …
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Investigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study
… MPD by investigating; (1) relative frequency (alpha, theta, beta and delta) at rest; (2) cognitive performance and relative frequency activity during the continuous performance task (CPT) and cued target detection task (CTD); (3) differences in the P300 event-related potential waveform (ERP), a …
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Functional DNA Aptamers as Biotherapeutic Molecules
… validated therapeutic targets, specifically the Tumour Necrosis Factor alpha (TNFα) and Carcinoembryonic Antigen (CEA), and block their biological functions. As well, I investigated the use of CEA and MUC1 binding aptamers as targeting agents to guide and detect the delivery of contrast …
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Directed Migration Achieved in Mammalian Cells via Ca2+ Signal Rewiring in Synthetic Protein Chimeras
… with green fluorescent protein, mCherry, tumour necrosis factor alpha and soluble CD14. The Ca2+ signal generation by the stimulus did not require a stringent transition from monomer to oligomer state but instead, only required an increase in the oligomeric state. The Ca2+ signal generated …
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The role of mast cells in a mouse model of focal cerebral ischaemia
… forty-five minutes post-tMCAo, indicated that tumour necrosis factor-alpha (TNF-α) was not responsible for the pathology seen in the WT mice, as it was found at similar concentrations in both mouse strains. However, endothelin-1, endoglin and matrixmetaloproteinase-9 were highly expressed in …
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