NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 25 for “"Tumour necrosis factor (TNF)."”.

  1. Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection

    Hacking, DamianDivision of Cardiology2011

    … Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the transcription factor signal transducer and activator of transcription 3 (STAT-3), has been identified as a key signalling pathway in cardioprotection, although the end …

    cape-town Repository record

  2. Metabolic reprogramming associated with the epithelial-mesenchymal transition in pancreatic cancer

    Liu, MenghanUNSW, Sydney2017

    … to two physiologically relevant EMT inducers, Tumour Necrosis Factor  (TNF) and Transformation Growth Factor  (TGF), and through stably overexpressing Snail in pancreatic cancer and non-tumourigenic human pancreatic ductal epithelial (HPDE) cells to examine the metabolic consequences. …

    unsw Repository record

  3. The neuroimmune response to cryptococcal infection

    Kauchali, MaahirDepartment of Human Biology2023

    … its purified capsule (a known major virulent factor) or lipopolysaccharide (LPS), and compared them to untreated control slices. The neuroimmune response was measured by tracking the activation of nuclear factor for interleukin 6 (NF-IL6), and confirmed by measuring the release of IL6 and …

    cape-town Repository record

  4. Coronary Artery Outcome in Kawasaki Disease: The Role of Matrix Metalloproteinase-9 and Therapeutic Modulation of Its Activity

    Lau, Andrew Chun-Ben2009

    … arteries. The pro-inflammatory cytokine, tumour necrosis factor (TNF)-α, was required for increasing local MMP-9 expression. Importantly, MMP-9-deficient animals had a significantly reduced incidence of elastin breakdown. Furthermore, in a cohort of KD patients, serum MMP-9 did not …

    toronto-retro Repository record

  5. Characterisation Of Cytokine Gene Polymorphisms In Patients With Acute Pancreatitis

    SARGEN, KEVIN1999

    … disorder of varied aetiology and outcome. Tumour necrosis factor (TNF) and interleukin-10 are important mediators of disease pathogenesis. To investigate if the TNF and IL-10 gene loci influence susceptibility to and severity of acute pancreatitis, 135 patients with acute pancreatitis, …

    plymouth Repository record

  6. Systemic Cytokine Expression and Endothelial Dysfunction: Insights from Innate Immune Models of Protein Phosphorylation

    Akbar, NaveedUniversity of Dundee2014

    … have shown associations between pro-inflammatory tumour necrosis factor (TNF) and interleukin-6 (IL-6) and adverse cardiovascular events. However, the early pathophysiological signalling responsible for the expression of inflammatory molecules in vascular dysfunction remains poorly defined with …

    dundee Repository record

  7. CNS endothelium expression of ADAM-17 and its role in multiple sclerosis pathogenesis.

    Hurst, Louise Anne.Sheffield Hallam University (United Kingdom).2009

    … with subsequent axonal damage. Various factors contribute to the pathogenesis of MS, including the breakdown of the blood-brain barrier (BBB), and increased local expression of inflammatory cytokines, matrix metalloproteinases (MMPs) and adhesion molecules. Upregulation of a distintegrin …

    sheffield-hallam Repository record

  8. Anti-TNF treatment of chronic arthritis in clinical practice. New assessment method and predictors of efficacy and tolerability.

    Kristensen, Lars ErikDepartment of Clinical Sciences, Lund University2008

    … introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. The overall objective of this thesis was to develop a new assessment method of efficacy of biological therapy in clinical …

    lund Repository record

  9. The role of cell type-specific tumour necrosis factor in protective immunity against neurotuberculosis

    Francisco, Ngiambudulu MbanduDivision of Immunology2013

    … cells that surround the bacteria. The cytokine tumour necrosis factor has been found to be involved in the recruitment of the immune cells and structure maintenance of granulomas. Tumour necrosis factor is a multifunctional proinflammatory cytokine which play a critical role in the initial and …

    cape-town Repository record

  10. Reactivation of persistant tuberculosis

    Botha, TaniaDivision of Immunology2003

    … of 168 ribosomal RNA (168 rRNA) and sigma factor A (sigA) gene expression revealed that large numbers of dormant bacilli are present in lung tissue during the persistent phase of infection in this model. This finding opens up the possibility that additional gene expression profiles can be …

    cape-town Repository record

  11. The Effects of Exercise-Induced Muscle Damage With or Without Omega-3 Supplementation on Inflammation, Muscle Function and Recovery in Healthy Physically Active Younger and Older Adults

    Kyriakidou, YvoniUniversity of Westminster2022

    … creatine kinase (CK), interleukin (IL)-6, and tumour necrosis factor (TNF)-α, prior, immediately after, and 1-to-72 hours post-EIMD. In addition, at the same time points in Study 2, extracellular vesicles (EVs) were assessed. In all studies, functional measures included maximal voluntary …

    westminster Repository record

  12. The role of oxygen free radicals in the endotoxic shock induced myocardial dysfunction and cellular injury

    Pattanaik, UttaraUniversity of Saskatchewan1996

    … levels of cytokines (interleukin-1 (IL-1) and tumour necrosis factor (TNF)), platelet activating factor (PAF), activated complement (C3a, C5a) and norepinephrine in the blood. Activated complement, IL-1, TNF and PAF are known to activate polymorphonuclear leukocytes (PMNLs), which on activation …

    sask Repository record

  13. Genomic profiling of response to $\textit{in vivo}$ immune perturbations

    Bai, Benjamin Yu HangUniversity of Cambridge2020

    … explore drug response in the Personalised Anti-TNF Therapy in Crohn’s Disease (PANTS) cohort: a cohort of Crohn’s disease (CD) patients treated with the anti-tumour necrosis factor (TNF) drugs, infliximab and adalimumab. Anti-TNF treatment has revolutionised patient care for CD, but 20–40% of …

    cambridge Repository record

  14. Stretch intensity and the inflammatory response

    Apostolopoulos, Nikos2015

    … 1 and 2), and for interleukin (IL)-1β, IL-6, and tumour necrosis factor (TNF)-α (study 1). In study three, a randomized controlled trial investigated whether stretching intensity (low or high), can influence the recovery from muscle damage. Thirty participants were randomized into three groups, a) …

    wlv Repository record

  15. Preparation and analysis of novel tumour-targeted delivery systems for prostate cancer therapy

    Al Robaian, MajedUniversity of Strathclyde2014

    … out to prepare and evaluate the efficacy of tumour- targeted transferrin, lactoferrin and lactoferricin conjugated polypropylenimine dendrimer as a novel gene delivery system able to improve the delivery of the therapeutic gene to cancer cells, in a safe and targeted way. We demonstrated that …

    strathclyde Repository record

  16. Effect of a maternal inflammatory challenge during the preimplantation period on offspring development and phenotype

    Williams, Charlotte LucyUniversity of Southampton2009

    … cytokines, e.g. interleukin-1? (IL-1?) and tumour necrosis factor-? (TNF-?). Prenatally, the maternal inflammatory challenge resulted in reduced ICM cell number and reduced ICM:TE cell ratio in GD 3.5 blastocysts, but did not affect the number of embryos generated or GD 17 litter size. …

    soton Repository record

  17. Treatment of arthritis with tumour necrosis factor antagonists. Clinical, immunological and biochemical aspects

    C Kapetanovic, MelihaDepartment of Rheumatology, Lund University2006

    … of the disease process have been introduced. Tumour necrosis factor (TNF) antagonists have been shown to reduce signs and symptoms of disease and to retard the development of tissue damage in the majority of patients. This thesis focuses on clinical, immunological and biochemical aspects of …

    lund Repository record

  18. Neuropathological role of alpha-synuclein: major contribution of inflammation in the evolution of both motor and non-motor symptoms of Parkinson’s disease

    PALMAS, MARIA FRANCESCAUniversità degli Studi di Cagliari2023

    … producing a large amount of the cytokine Tumour Necrosis Factor (TNF)-α. In contrast, Pom inhibited the TNF-α overproduction and elevated the anti-inflammatory cytokine Interleukin (IL)-10. Moreover, the H-αSynOs infusion induced a systemic inflammation with a dysregulated production of …

    cagliari Repository record

  19. Describing the immune cell profile of ventricular cerebrospinal fluid (CSF) in paediatric central nervous system (CNS) infections

    Morris, KateDivision of General Surgery2025

    … IL-8, IL-10, IL-1 receptor antagonist (IL-1Ra), tumour necrosis factor (TNF)-, interferon (IFN)-, IFN-, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory proteins (MIP)-1 and interferon-inducible protein 10 (IP-10) using Luminex® …

    cape-town Repository record

  20. Cytokine secretion in glioblastoma patients

    Zisakis, AthanasiosUniversity of Central Lancashire2008

    Gliomas are the most common primary tumours of the central nervous system with a lethality rate approaching 80% in the first year of glioblastoma diagnosis. Their highly invasive nature renders local therapies such as surgery and radiation ineffective; whereas novel approaches such as immunotherapy …

    cent-lancashire Repository record

Page 1 of 2